A new strategy for identifying polysialylated proteins reveals they are secreted from cancer cells as soluble proteins and as part of extracellular vesicles
Abstract:Polysialic acid (polySia) is a long homopolymer consisting of α2,8–linked sialic acid with tightly regulated expression in humans. In healthy adults, it occurs on cell surface glycoproteins in neuronal, reproductive, and immune tissues; however, it is aberrantly present in many cancers and its overexpression correlates with significantly increased metastasis and poor prognosis. Prompted by the observation that the MCF–7 breast cancer cell line contains only intracellular polySia, we investigated the secretion … Show more
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