A new straightforward approach to 3-(arylideneamino)hydantoins

A general and stereoselective approach to 14-membered cyclic bis-semicarbazones involving BF3-catalyzed amidoalkylation of 2-(trimethylsilyloxy)propene

“…An important additional challenge was to extend the scope of the synthetic utility of amidoalkylating reagents 5 . Recently, we have demonstrated that these reagents are very effective in amidoalkylation of a variety of both rather strong O -, S -, N -, H -, P -, and C -nucleophiles 17,18 and weak C -nucleophiles (enamines). 19 Here, we aimed to explore the amidoalkylation of weaker nucleophiles, in particular vinyl ethers, using reagents 5 .…”