A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data

Eickhoff, Simon B.; Stephan, Klaas Ε.; Mohlberg, Hartmut; Grefkes, Christian; Fink, Gereon R.; Amunts, Katrin; Zilles, Karl

doi:10.1016/j.neuroimage.2004.12.034

Cited by 3,811 publications

(3,256 citation statements)

References 34 publications

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“…From the Talaraiched structural images, the TT_N27 atlas in AFNI, based on the Eickhoff–Zilles cytoarchitectonic probabilistic atlas developed in the SPM Anatomy Toolbox (Eickhoff et al., 2005), was used to anatomically identify our a priori primary regions of interest (ROI): the left and right amygdala for each participant. To assess group‐level differences in functional connectivity, a bilateral amygdala ROI was used.…”

Section: Methodsmentioning

confidence: 99%

Interpersonal early‐life trauma alters amygdala connectivity and sustained attention performance

et al. 2017

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IntroductionInterpersonal early life trauma (I‐ELT) is associated with a myriad of functional impairments in adulthood, increased risk of drug addiction, and neuropsychiatric disorders. While deficits in emotional regulation and amygdala functioning are well characterized, deficits in general cognitive functioning have also been documented. However, the neural underpinnings of cognitive dysfunction in adults with a history of I‐ELT and the potential relationship between amygdala‐based functional connectivity and behavioral performance are currently poorly understood. This study examined how I‐ELT affects the cognitive and neural mechanisms supporting sustained attention.MethodsA total of 66 Veterans (18 with and 48 without a history of I‐ELT) completed a nonemotional sustained attention task during functional MRI.ResultsThe individuals with I‐ELT showed significant impairments in sustained attention (i.e., higher error rates, greater response variability). This cohort exhibited increased amygdala functional connectivity with the prefrontal cortex and decreased functional connectivity with the parahippocampal gyrus when compared to those without I‐ELT. These connections were significantly correlated with individual differences in sustained attention performance. Notably, classification analyses revealed that the pattern of amygdala connectivity across the whole brain was able to classify I‐ELT status with 70% accuracy.ConclusionThese results provide evidence of a lasting negative impact for those with a history of I‐ELT on sustained attention ability. They also highlight a critical role for amygdala functioning in cognitive control and sustained attention for those with a history of I‐ELT, which may underlie the observed attention deficits in clinical assessments and cognitive tests involving both emotional and nonemotional stimuli.

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Section: Methodsmentioning

confidence: 99%

Interpersonal early‐life trauma alters amygdala connectivity and sustained attention performance

et al. 2017

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“…Anatomical designation of the regional effects were based upon maxima or peaks in the ensuing statistical parametric maps: cluster peaks were first extracted using the Peak_nii software (www.nitrc.org/projects/peak_nii) and then labelled using the cytoarchitectonic probability maps provided by the SPM Anatomy toolbox [Eickhoff et al, 2005, 2007b]. The SPM anatomy toolbox included individual areas such as: primary motor cortex [Brodmann areas (BA) 4a and 4p] [Geyer et al, 1996], premotor cortex (BA 6) [Geyer, 2003], primary somatosensory cortex (BA 3a, 3b, 1) [Geyer et al, 1996], somatosensory cortex (BA 2) [Grefkes et al, 2001], parietal operculum or S2 (OP 1‐4) [Eickhoff et al, 2006a, 2006b,2007a], intraparietal sulcus [Choi et al, 2006; Scheperjans et al, 2008a, 2008b], superior parietal cortex [Scheperjans et al, 2008a,,b], inferior parietal cortex [Caspers et al, 2008], and visual areas (V4) [Rottschy et al, 2007] (V4) [Malikovic et al, 2007].…”

Section: Methodsmentioning

confidence: 99%

Differential involvement of cortical and cerebellar areas using dominant and nondominant hands: An FMRI study

Alahmadi

Pardini

Samson

et al. 2015

Human Brain Mapping

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Motor fMRI studies, comparing dominant (DH) and nondominant (NDH) hand activations have reported mixed findings, especially for the extent of ipsilateral (IL) activations and their relationship with task complexity. To date, no study has directly compared DH and NDH activations using an event‐related visually guided dynamic power‐grip paradigm with parametric (three) forces (GF) in healthy right‐handed subjects. We implemented a hierarchical statistical approach aimed to: (i) identify the main effect networks engaged when using either hand; (ii) characterise DH/NDH responses at different GFs; (iii) assess contralateral (CL)/IL‐specific and hemisphere‐specific activations. Beyond confirming previously reported results, this study demonstrated that increasing GF has an effect on motor response that is contextualised also by the use of DH or NDH. Linear analysis revealed increased activations in sensorimotor areas, with additional increased recruitments of subcortical and cerebellar areas when using the NDH. When looking at CL/IL‐specific activations, CL sensorimotor areas and IL cerebellum were activated with both hands. When performing the task with the NDH, several areas were also recruited including the CL cerebellum. Finally, there were hand‐side‐independent activations of nonmotor‐specific areas in the right and left hemispheres, with the right hemisphere being involved more extensively in sensori‐motor integration through associative areas while the left hemisphere showing greater activation at higher GF. This study shows that the functional networks subtending DH/NDH power‐grip visuomotor functions are qualitatively and quantitatively distinct and this should be taken into consideration when performing fMRI studies, particularly when planning interventions in patients with specific impairments. Hum Brain Mapp 36:5079–5100, 2015. © 2015 Wiley Periodicals, Inc.

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“…This initial averaging reduces the possibility of detecting any effect that is highly localized in the brain. Alternative applications of the method may consider different templates, for example using cytoarchitectonic‐based atlases [Eickhoff et al, 2005] or defining ad hoc templates based on independent functional data. The latter could include the investigation of network re‐configurations within the occipital visual cortex, by first constructing a specific template based on individual retinotopic maps.…”

Section: Discussionmentioning

confidence: 99%

Time‐resolved detection of stimulus/task‐related networks, via clustering of transient intersubject synchronization

Bordier

Macaluso

2015

Human Brain Mapping

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Several methods are available for the identification of functional networks of brain areas using functional magnetic resonance imaging (fMRI) time‐series. These typically assume a fixed relationship between the signal of the areas belonging to the same network during the entire time‐series (e.g., positive correlation between the areas belonging to the same network), or require a priori information about when this relationship may change (task‐dependent changes of connectivity). We present a fully data‐driven method that identifies transient network configurations that are triggered by the external input and that, therefore, include only regions involved in stimulus/task processing. Intersubject synchronization with short sliding time‐windows was used to identify if/when any area showed stimulus/task‐related responses. Next, a first clustering step grouped together areas that became engaged concurrently and repetitively during the time‐series (stimulus/task‐related networks). Finally, for each network, a second clustering step grouped together all the time‐windows with the same BOLD signal. The final output consists of a set of network configurations that show stimulus/task‐related activity at specific time‐points during the fMRI time‐series. We label these configurations: “brain modes” (bModes). The method was validated using simulated datasets and a real fMRI experiment with multiple tasks and conditions. Future applications include the investigation of brain functions using complex and naturalistic stimuli. Hum Brain Mapp 36:3404–3425, 2015. © 2015 The Authors Human Brain Mapping Published by Wiley Periodicals, Inc.

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A new SPM toolbox for combining probabilistic cytoarchitectonic maps and functional imaging data

Cited by 3,811 publications

References 34 publications

Interpersonal early‐life trauma alters amygdala connectivity and sustained attention performance

Interpersonal early‐life trauma alters amygdala connectivity and sustained attention performance

Differential involvement of cortical and cerebellar areas using dominant and nondominant hands: An FMRI study

Time‐resolved detection of stimulus/task‐related networks, via clustering of transient intersubject synchronization

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