A new spirotryprostatin from the marine isolate of the fungus Aspergillus fumigatus

Afiyatullov, Sh. Sh.; Zhuravleva, Olesya I.; Чайкина, Е. Л.; Anisimov, M. M.

doi:10.1007/s10600-012-0166-8

Cited by 20 publications

(17 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…155 Two costaclavine alkaloids 143 and 144 were obtained from Aspergillus fumigatus (zoanthid Zoanthus sp., Amami Is., Kagoshima, Japan), 156 while A. fumigatus (so coral Sinularia sp., Kunashir Is., Kuril Islands) produced the spirocyclic diketopiperazine alkaloid spirotryprostatin F 145 which had stimulatory phytoregulatory activity. 157 The same fungal strain was the source of the alkaloid fumiquinazoline K 146 and a nordammarane triterpenoid 147. 158 From A. fumigatus (intertidal mud, Yingkou, China) several diketopiperazines were isolated: prenylcyclotryprostatin B 148, 20hydroxycyclotryprostatin B 149, 9-hydroxyfumitremorgin C 150, 6hydroxytryprostatin B 151 and spirogliotoxin 152.…”

Section: Marine-sourced Fungi (Excluding From Mangroves)mentioning

confidence: 99%

Marine natural products

et al. 2014

View full text Add to dashboard Cite

This review covers the literature published in 2012 for marine natural products, with 1035 citations (673 for the period January to December 2012) referring to compounds isolated from marine microorganisms and phytoplankton, green, brown and red algae, sponges, cnidarians, bryozoans, molluscs, tunicates, echinoderms, mangroves and other intertidal plants and microorganisms. The emphasis is on new compounds (1241 for 2012), together with the relevant biological activities, source organisms and country of origin. Biosynthetic studies, first syntheses, and syntheses that lead to the revision of structures or stereochemistries, have been included.

show abstract

Section: Marine-sourced Fungi (Excluding From Mangroves)mentioning

confidence: 99%

Marine natural products

et al. 2014

View full text Add to dashboard Cite

show abstract

“…Spiro-diketopiperazines are present in many natural products [38–40] and have recently received much attention as pharmacologically active peptidomimetics [41–43]. …”

Section: Resultsmentioning

confidence: 99%

Asymmetric Ugi 3CR on isatin-derived ketimine: synthesis of chiral 3,3-disubstituted 3-aminooxindole derivatives

Lesma¹,

Meneghetti²,

Sacchetti³

et al. 2014

Beilstein J. Org. Chem.

View full text Add to dashboard Cite

SummaryAn efficient Ugi three-component reaction of a preformed chiral ketimine derived from isatin with various isonitrile and acid components has been developed. The reactions proceeded smoothly and in a stereocontrolled manner with regard to the new center of the Ugi products due to the stereoinduction of the amine chiral residue. A wide variety of novel chiral 3,3-disubstituted 3-aminooxindoles were obtained, a selection of which were subjected to post-Ugi transformations, paving the way to application as peptidomimetics.

show abstract

“…Wang et al (2012b) isolated four IDPs from A. fumigatus YK-7 including prenylcyclotryprostatin B (61), 20-hydroxycyclotryprostatin B (62), 9-hydroxyfumitremorgin C (63), and 6-hydroxytryprostatin B (64), among which compounds 61 and 63 showed good cytotoxic activity against U937 with IC 50 values of 25.3 and 18.2 μmol/L, respectively. Spirotryprostatin F (65) was isolated from the marine isolate of the fungus A. fumigatus KMM 4631 (Afiyatullov et al 2012). This compound exhibited stimulating action on the growth of sprout roots of Glycine max (L.) Merr, Zea mays L. and Fagopyrum esculentum Moench in low and ultralow doses (10 −6 -10 −17 mol/L).…”

Section: Idps From the Fungal Genus Aspergillusmentioning

confidence: 99%

Chemical diversity and biological function of indolediketopiperazines from marine-derived fungi

Cao

Wang

2020

Mar Life Sci Technol

View full text Add to dashboard Cite

Natural products from marine-derived fungi have attracted considerable attention in the recent two decades. Indolediketopiperazines are one of the most important classes of marine natural products, mainly discovered from the fungal genera Penicillium, Aspergillus and Eurotium. These compounds span a wide range of chemical structures and bioactivities. This review summarizes 155 indolediketopiperazines that were discovered from marine-derived fungi from 2000 to early 2019 and primarily focuses on their chemical diversity and biological function.

show abstract

A new spirotryprostatin from the marine isolate of the fungus Aspergillus fumigatus

Cited by 20 publications

References 5 publications

Marine natural products

Marine natural products

Asymmetric Ugi 3CR on isatin-derived ketimine: synthesis of chiral 3,3-disubstituted 3-aminooxindole derivatives

Chemical diversity and biological function of indolediketopiperazines from marine-derived fungi

Contact Info

Product

Resources

About