A new species of the oligotrophic genus Ochroconis (Sympoventuriaceae)

Samerpitak, Kittipan; Duarte, A. P. M.; Attili‐Angelis, Derlene; Pagnocca, Fernando Carlos; Heinrichs, G.; Rijs, Antonius J. M. M.; Alfjorden, Anders; Ende, A. H. G. Gerrits van den; Menken, Steph B. J.; Hoog, G.S. de

doi:10.1007/s11557-015-1023-5

Cited by 24 publications

(25 citation statements)

References 17 publications

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“…E. spinifera is a dematiaceous fungus responsible for 33 reported cases of subcutaneous and invasive phaeohyphomycosis, which mostly occurred in tropical and subtropical areas (Bohelay et al, 2016). O. musae, a new combined name of Scolecobasidium musae and Ochroconis mirabilis, is the most common Ochroconis species and can occasionally cause cutaneous infections in humans (Hao et al, 2013;Samerpitak et al, 2014Samerpitak et al, , 2015. C. cassiicola is a rare plant pathogen responsible for four reported cases of fungal keratitis and phaeohyphomycosis (Huang et al, 2010;Lv et al, 2011;Mahgoub, 1969;Yamada et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Impaired Specific Antifungal Immunity in CARD9-Deficient Patients with Phaeohyphomycosis

Wang

Zhang

et al. 2018

Journal of Investigative Dermatology

114

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Phaeohyphomycosis is a group of severe infections caused by dematiaceous fungi. We previously identified CARD9 deficiencies in four Chinese patients with phaeohyphomycosis caused by Phialophora verrucosa. In this study, we sought to identify the genetic and immunological mechanisms underlying rare dematiaceous fungal infections in three otherwise healthy patients with phaeohyphomycosis caused by Exophiala spinifera, Ochroconis musae, and Corynespora cassiicola. CARD9 sequencing in these patients showed one mutation (p.S23X) that, to our knowledge, has not been characterized and two previously characterized mutations (p.D274fsX60 and p.L64fsX59) that led to lack of CARD9 protein expression. Patient-derived CARD9-deficient cells showed a selective impairment of proinflammatory cytokine and chemokine production, NF-κB activation, and T helper type 22- and T helper type 17-associated responses upon fungus-specific stimulation, whereas phagocytosis and reactive oxygen species production were intact. Consistently, Card9-knockout mice were highly susceptible to phaeohyphomycosis and exhibited immune deficiencies similar to those of patients, including diminished NF-κB and p38 MAPK activation in local and in vitro functional studies. This work clarifies the association between inherited CARD9 deficiencies and phaeohyphomycosis, and furthers current knowledge on the spectrum and pathophysiology of diseases resulting from CARD9 deficiencies.

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Section: Discussionmentioning

confidence: 99%

Impaired Specific Antifungal Immunity in CARD9-Deficient Patients with Phaeohyphomycosis

Wang

Zhang

et al. 2018

Journal of Investigative Dermatology

114

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“…Therefore, Ochroconis was thought to adapt to various environments and distribute widely both in animals and plants Samerpitak et al, 2014 . Moreover, previous studies showed that Ochroconis was found not only outdoors but, often, also in indoor locations, especially detergentrich environments such as bathroom areas and washing machines Hamada, 2005;Lain and de Hoog, 2010;Samerpitak et al, 2015 . Ochroconis humicola isolated from detergent-rich environments could use detergents as nutrients, which is unique because surfactants generally inhibit the growth of fungi Hamada and Abe, 2009 .…”

Section: Introductionmentioning

confidence: 99%

Molecular and Biological Differences Among <i>Ochroconis</i> Strains Collected from Indoor and Outdoor Environments

Hamada

Abe²

2018

Biocontrol Sci.

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The molecular, morphological, and physiological characters of 55 Ochroconis strains collected from indoor and outdoor environments were studied. In Japan, Ochroconis species are often found in indoor detergent-rich environments, such as bathrooms and washing machines, and the predominant species have been identified as O. humicola, similar to that in other Asian and European countries. Although Ochroconis species have rarely been found in outdoor environments such as mountains, forests, and agricultural fields, in the present study, Ochroconis strains were specifically isolated from the soils of urban city parks. Phylogenetic analysis conducted using the 28S ribosomal RNA 28S rDNA gene sequence showed that almost all of the Ochroconis strains found in indoor environments i.e., water supply were O. humicola. Although city parks were often surrounded by residences, more than half of the Ochroconis strains collected from the soils of city parks examined in this study were different Ochroconis species. The ability to use detergents as nutrients was found in a new genetic group probably a new species isolated from the soils of city parks as well as in O. humicola and O. constricta. Ochroconis humicola is assumed to adapt mostly to indoor environments and to penetrate from the outdoors, e.g., soils of urban areas. To elucidate the factors promoting indoor fungal predominance, the ability of using surfactants as nutrients was compared among these three species. Additionally, growth under alkaline and drought conditions, and heat tolerance were examined. Indoor predominance of O. humicola compared to that of the other two species was attributed to the ability of using a non-ionic surfactant as nutrient and to growth under alkaline conditions.

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“…Ochroconis musae which was predominant at the outer-tub of washing machine A and the pulsator of washing machine B is the most common species of the Ochroconis genus which is associated with infection on vertebrates Samerpitak et al, 2015 . This fungus was recorded as a new species in 2013 and was named Scolecobasidium musae at first Hao et al, 2013 .…”

Section: Discussionmentioning

confidence: 99%

Genetic Identification of Dematiaceous Fungi Isolated from Washing Machine in Japan, and Considering of Fungal Removal Methods

Hara¹,

Fujii

Kawakami³

2019

Biocontrol Sci.

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In 2017, 2 household washing machines which were used at a house in Saitama prefecture were tested for fungal flora sampling. The fungi were identified in detail via genetic analysis of the ITS region. The number of fungi which were isolated were 8.7 10 6 6.1 10 7 cfu/100cm 2 and dematiaceous fungi such as Ochroconis musae, Exophiala, Cyphellophora, Knufia epidermidis were dominant. As for Knufia epidermidis, this is the first report for identification from a Japanese household. The number of isolated Cladosporium, which is common in the environment, was fewer compared with the above 4 genera. The identified fungi were Cladosporium halatolerans, which is recently being recognized as the main species of Cladosporium. In our research, we have cleaned the 2 washing machines with different bleaches. Residual fungi was detected in washing machine A, which was cleaned with an oxygen bleach. On the other hand, no fungi was detected in washing machine B, which was cleaned with a chlorine bleach.

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A new species of the oligotrophic genus Ochroconis (Sympoventuriaceae)

Cited by 24 publications

References 17 publications

Impaired Specific Antifungal Immunity in CARD9-Deficient Patients with Phaeohyphomycosis

Impaired Specific Antifungal Immunity in CARD9-Deficient Patients with Phaeohyphomycosis

Molecular and Biological Differences Among <i>Ochroconis</i> Strains Collected from Indoor and Outdoor Environments

Genetic Identification of Dematiaceous Fungi Isolated from Washing Machine in Japan, and Considering of Fungal Removal Methods

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