A new species,<i>Aspergillus persii</i>, as an agent of onychomycosis

Zotti, Mirca; Machetti, Marco; Perotti, Maddalena; Barabino, Gianfranco; Persi, A

doi:10.3109/13693780903420641

Cited by 21 publications

(11 citation statements)

References 11 publications

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“…However, both P. lilacinus and Cunninghamella bertholletiae , isolated by infected big toes, were found in patients with known immunological deficiencies. We also found A. persii , already reported in medical literature to be associated with opportunistic onychomycosis . A. persii was isolated from the big toe of a woman, where it was diagnosed as the putative agent of a distal lateral onychomycosis (Fig.…”

Section: Resultssupporting

confidence: 80%

Non‐dermatophytic onychomycosis diagnostic criteria: an unresolved question

Bombace

Iovene

Galdiero

et al. 2016

Mycoses

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Non-dermatophytic moulds (NDMs) have been increasingly recognised as causative agents of onychomycosis. The diagnosis of onychomycosis is most often obtained by microscopic observation of nail specimens where fungal elements can be detected and cultured by standard mycological techniques. Direct microscopic examination does not always result positive in NDM onychomycosis; therefore to perform a correct diagnosis, a proper mycological culture is often required. The purpose of our study was to evaluate the role of direct microscopic examination in the NDM onychomycosis diagnosis. The results show that only 57.2% of the specimens from onychomycosis patients could be properly diagnosed showing positivity to both direct microscopic examination and NDMs culture isolation in two or more subsequent inoculations, while 42.8% of analysed specimens with a negative direct microscopic examination, showed NDMs growth after three or more subsequent inoculations. The large proportion of false negatives (more than 42%) could be related to the duration of the infection and/or to the experience and skills of the personnel dedicated to specimen collection. We point out the need for thoroughly evaluating all specimens showing cultural growth in at least three subsequent medium inoculations, whatever the result of the microscopic examination, in order to reduce false-negative rates. This strategy would allow for more accurate diagnosis of this mycosis.

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Section: Resultssupporting

confidence: 80%

Non‐dermatophytic onychomycosis diagnostic criteria: an unresolved question

Bombace

Iovene

Galdiero

et al. 2016

Mycoses

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“…Although the section Circumdati is generally characterized by the production of nephrotoxic ochratoxin A, this species produces this substance in trace amounts . The emerging etiologic species of onychomycosis include A. insulicola , A. melleus , A. ochraceopetaliformis , A. ochraceus , A. persii , A. sclerotiorum and A. westerdijkiae . The level of airborne fungi and Aspergillus section Circumdati was high in the houses involved in the Fukushima Daiichi nuclear disaster in August 2012 .…”

Section: Discussionmentioning

confidence: 99%

Onychomycosis caused by Aspergillus subramanianii

Hirose

Noguchi

Yaguchi

et al. 2018

The Journal of Dermatology

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We describe a case of a 23-year-old female patient with no apparent underlying diseases. She showed a discoloration of the proximal portion of the left big toenail with paronychia. Direct microscopy revealed septate hyphae with conidiophores, and a periodic acid-Schiff-stained nail specimen revealed septate hyphae branching at angles of approximately 45°. On the basis of phylogenetic analysis, we finally arrived at the diagnosis of ungual aspergillosis caused by Aspergillus subramanianii. After p.o. administration of terbinafine and topical application of 10% efinaconazole solution, the disease resolved in 6 months. A. subramanianii is one of the new species in the genus Aspergillus section Circumdati. Reported clinical isolates have been isolated from lung tissue, wounds and feet. This is the first documented case of onychomycosis caused by A. subramanianii. Onychomycosis due to Aspergillus species is uncommon. We summarized the reported cases of ungual aspergillosis in Japan.

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“…They can also cause infections, although infrequently. A. ochraceus, A. sclerotiorum and A. persii have been described as agents of onychomycosis (4,8,9). A. westerdijkiae, A. insulicola A. tritici and A. pallidofulvus have also been recognized as pathogens for humans (6).…”

Section: Resultsmentioning

confidence: 99%