A New Spatane Diterpenoid from the Cultured Soft Coral Sinularia leptoclados

Tsai, Tsung‐Chang; Wu, Yu-Jen; Su, Jui‐Hsin; Lin, Wei-Tung; Lin, Yun‐Sheng

doi:10.3390/md11010114

Cited by 16 publications

(22 citation statements)

References 25 publications

(25 reference statements)

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“…Because all the corals are claimed to be threatened species, we therefore want to culture these interesting specimens as sources of potential natural products. In previous studies on the chemical constituents of cultured octocorals, a series of interesting secondary metabolites were obtained from Erythropodium caribaeorum [3], Klyxum simplex [4,5,6,7], Lobophytum crassum [8], Sarcophyton trocheliophorum [9], Sinularia flexibilis [10], Sinularia leptoclados [11], Briareum excavatum [12,13,14,15,16,17,18,19,20] and Briareum sp. [21].…”

Section: Introductionmentioning

confidence: 99%

Flexibilisquinone, a New Anti-Inflammatory Quinone from the Cultured Soft Coral Sinularia flexibilis

et al. 2013

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A new quinone derivative, flexibilisquinone (1), was isolated from the cultured soft coral Sinularia flexibilis, originally distributed in the waters of Taiwan. The structure of quinone 1 was established by extensive spectroscopic methods, particularly 1D and 2D NMR experiments. In the in vitro anti-inflammatory effects test, quinone 1 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS and COX-2 proteins of the LPS-stimulated RAW264.7 macrophage cells.

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Section: Introductionmentioning

confidence: 99%

Flexibilisquinone, a New Anti-Inflammatory Quinone from the Cultured Soft Coral Sinularia flexibilis

et al. 2013

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“…Spatane diterpenoids were first obtained in 1980 from the brown alga Spatoglossum schmittii from the Galapagos Islands [38]. Subsequently, several spatane diterpenoids were isolated from other species of brown algae and soft corals [39,40].…”

Section: Discussionmentioning

confidence: 99%

Spatane diterpinoid from the brown algae, Stoechospermum marginatum induces apoptosis via ROS induced mitochondrial mediated caspase dependent pathway in murine B16F10 melanoma cells

Velatooru

Baggu

Janapala

2016

Molecular Carcinogenesis

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Spatane diterpinoids isolated from the brown marine algae Stoechospermum marginatum were known to have cytotoxic effects in human cancerous cell lines and murine melanoma cells; the underling apoptotic mechanism of diterpinoids still remains unclear so far. Thus, in the present study, the apoptotic mechanism of a spatane diterpinoid, 5(R), 19-diacetoxy-15,18(R and S), dihydro spata-13, 16(E)-diene (DDSD) was investigated mainly in B16F10 melanoma cells because they were most susceptible to DDSD than THP1, U937, COLO205, and HL60 cells. The treatment of B6F10 cells with DDSD resulted in morphological alterations, nuclear condensation, and DNA fragmentation, which leads to cell growth inhibition in a concentration-dependent manner. Data indicate that DDSD induced the generation of ROS, consequentially caused alteration in Bax/Bcl-2 ratio that disrupted the inner mitochondrial transmembrane potential (ΔΨm) resulting in cytochrome c redistribution to the cytoplasm and activation of caspase-mediated apoptotic pathway. Flow cytometric analysis clearly indicated that the DDSD inducing phosphatidylserine externalization and mediated "S-phase" arrest in cell cycle. In addition, results also found that DDSD induced apoptosis through deregulating PI3K/AKT signaling pathway. The anti-tumor activity of DDSD was evaluated in C57BL/6 mice bearing B16F10 melanoma. It effectively inhibited tumor growth (volume and weight) in a dose dependent manner, yet without apparent toxic effects. Morphology and apoptotic status of tumor tissues in the treated mice were assessed by microscopy and TUNEL assay, respectively. Our study shows a therapeutic potential of DDSD for the treatment of malignant melanoma and a new source of anticancer drugs. © 2016 Wiley Periodicals, Inc.

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“…Up to now, Sinularia has yielded many metabolites, including sesquiterpenes, diterpenes, alkaloids, and polyhydroxylated steroids [6,7,8,9,10,11,12]. These metabolites display a wide range of biological activities, such as antimicrobial, anti-inflammatory, and cytotoxic activities [13,14,15,16,17,18].…”

Section: Introductionmentioning

confidence: 99%

“…The genus Sinularia is the most widely distributed soft coral, consisting of almost 90 species, of which more than 50 have been chemically examined [ 1 , 2 , 3 , 4 , 5 ]. Up to now, Sinularia has yielded many metabolites, including sesquiterpenes, diterpenes, alkaloids, and polyhydroxylated steroids [ 6 , 7 , 8 , 9 , 10 , 11 , 12 ]. These metabolites display a wide range of biological activities, such as antimicrobial, anti-inflammatory, and cytotoxic activities [ 13 , 14 , 15 , 16 , 17 , 18 ].…”

Section: Introductionmentioning

confidence: 99%

New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.

et al. 2013

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Four new sesquiterpenes, sinularianins C–F (3–6), together with known sinularianins A (1) and B (2) were identified from a South China Sea soft coral Sinularia sp. Compounds 1–6 were evaluated for inhibition of NF-κB activation using the cell-based HEK293 NF-κB luciferase reporter gene assay. Compounds 1 and 4 were exhibited a potent effect with inhibitory rates of 41.3% and 43.0% at the concentration of 10 µg/mL, respectively.

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A New Spatane Diterpenoid from the Cultured Soft Coral Sinularia leptoclados

Cited by 16 publications

References 25 publications

Flexibilisquinone, a New Anti-Inflammatory Quinone from the Cultured Soft Coral Sinularia flexibilis

Flexibilisquinone, a New Anti-Inflammatory Quinone from the Cultured Soft Coral Sinularia flexibilis

Spatane diterpinoid from the brown algae, Stoechospermum marginatum induces apoptosis via ROS induced mitochondrial mediated caspase dependent pathway in murine B16F10 melanoma cells

New Sinularianin Sesquiterpenes from Soft Coral Sinularia sp.

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