A New SNP in the 3′-UTR of the hsp 70-1 Gene in Bos taurus and Bos indicus

Adamowicz, Tatiana; Pers, E.; Lechniak, D.

doi:10.1007/s10528-005-9119-2

Cited by 24 publications

(12 citation statements)

References 8 publications

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“…These data do not agree with findings of Adamowicz et al (2005), who reported polymorphic alleles for the same SNPs in Holstein Polish population. Results from our study and study from Adamowicz et al (2005) support the concept that in the same breed but different population, the allele frequency of a specific SNP is not repeatable. The significant novel aspect of our studies is that we have ascertained the presence of 5′-UTR variants in the inducible bovine Hsp70.1 gene in Holstein dairy cows.…”

Section: Discussioncontrasting

confidence: 99%

“…The two SNPs within the 3′-UTR that were described by Grosz et al (1994) and Adamowicz et al (2005) in the bovine Hsp70.1 gene of Holstein breed were not related to any physiological or productive traits. In Chinese Holstein cows, a genetic polymorphism in the coding region of Hsp70.1 gene was associated with resistance to mastitis (Cheng et al 2009).…”

Section: Discussionmentioning

confidence: 85%

“…Based on the identification of SNPs by Grosz et al (1994) (g2154 G/A) and by Adamowicz et al (2005) (g64 G/T) in the bovine Hsp70.1 3′-UTR of Holstein dairy breed, and on the identification of two SNPs (g895 C/-and g1128 G/T) by Starkey et al (2007) in the bovine Hsp70 5′-UTR of Brahman meat breed, specific primers (Table 1) were used for SNPs characterization in the 446 cows.…”

Section: Animals and Sample Collectionmentioning

confidence: 99%

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Cellular thermotolerance is associated with heat shock protein 70.1 genetic polymorphisms in Holstein lactating cows

Basiricò

Morera

Primi

et al. 2011

Cell Stress and Chaperones

125

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Heat shock proteins (Hsp) are known to protect cells from several stressors. Nucleotide changes in the flanking regions [5′-and 3′-untranslated region (UTR)] of Hsp gene might affect inducibility, degree of expression, or stability of Hsp70 mRNA. The present study aimed to investigate the association between inducible Hsp70.1 single nucleotide polymorphisms (SNPs) and heat shock (HS) response of peripheral blood mononuclear cells (PBMC) in dairy cows. Four hundred forty-six Italian Holstein cows were genotyped for four Hsp70

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Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 85%

Section: Animals and Sample Collectionmentioning

confidence: 99%

See 1 more Smart Citation

Cellular thermotolerance is associated with heat shock protein 70.1 genetic polymorphisms in Holstein lactating cows

Basiricò

Morera

Primi

et al. 2011

Cell Stress and Chaperones

125

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“…In beef cattle, 10 SNPs in the promoter region of the bovine Hsp70.1 gene were identified and they were associated with weaning weights and pregnancy (Banks et al, 2007;Starkey et al, 2007). On the other hand, there are only two polymorphisms identified in the 3 0 UTR of bovine Hsp70.1 gene in dairy cattle (Grosz et al, 1994;Adamowicz et al, 2005), but the association between Hsp70 gene polymorphism and production traits or thermotolerance was not studied. Cheng et al (2009) reported a genetic polymorphism of Hsp70.1 gene and its association with resistance to mastitis in Chinese Holstein.…”

Section: Hsp70 Genotype and Heat Stressmentioning

confidence: 99%

Metabolic and hormonal acclimation to heat stress in domesticated ruminants

Bernabucci

Lacetera

Baumgard

et al. 2010

Animal

715

492

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Environmentally induced periods of heat stress decrease productivity with devastating economic consequences to global animal agriculture. Heat stress can be defined as a physiological condition when the core body temperature of a given species exceeds its range specified for normal activity, which results from a total heat load (internal production and environment) exceeding the capacity for heat dissipation and this prompts physiological and behavioral responses to reduce the strain. The ability of ruminants to regulate body temperature is species-and breed-dependent. Dairy breeds are typically more sensitive to heat stress than meat breeds, and higher-producing animals are more susceptible to heat stress because they generate more metabolic heat. During heat stress, ruminants, like other homeothermic animals, increase avenues of heat loss and reduce heat production in an attempt to maintain euthermia. The immediate responses to heat load are increased respiration rates, decreased feed intake and increased water intake. Acclimatization is a process by which animals adapt to environmental conditions and engage behavioral, hormonal and metabolic changes that are characteristics of either acclimatory homeostasis or homeorhetic mechanisms used by the animals to survive in a new 'physiological state'. For example, alterations in the hormonal profile are mainly characterized by a decline and increase in anabolic and catabolic hormones, respectively. The response to heat load and the heat-induced change in homeorhetic modifiers alters post-absorptive energy, lipid and protein metabolism, impairs liver function, causes oxidative stress, jeopardizes the immune response and decreases reproductive performance. These physiological modifications alter nutrient partitioning and may prevent heat-stressed lactating cows from recruiting glucose-sparing mechanisms (despite the reduced nutrient intake). This might explain, in large part, why decreased feed intake only accounts for a minor portion of the reduced milk yield from environmentally induced hyperthermic cows. How these metabolic changes are initiated and regulated is not known. It also remains unclear how these changes differ between short-term v. long-term heat acclimation to impact animal productivity and well-being. A better understanding of the adaptations enlisted by ruminants during heat stress is necessary to enhance the likelihood of developing strategies to simultaneously improve heat tolerance and increase productivity.Keywords: ruminants, heat stress, metabolism, acclimation, adaptation ImplicationsHeat stress is a significant financial burden to animal agriculture in most areas of the world. Acclimation to heat stress imposes behavioral, physiological and metabolic adjustments to reduce the strain and enhances the likelihood of surviving the stress, and it also frequently reduces ruminant performance and compromises health. Improving our knowledge of physiological and metabolic mechanisms of acclimation may contribute to the development and adoption of proce...

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“…The HSP70 family, ranging between 68 to 73 kDa (Adamowicz et al, 2005), are responsible for a wide range of protein folding processes that include the folding and assembly of newly synthesised proteins; refolding of misfolded and aggregated proteins; membrane translocation of organellar and secretory proteins; and controlling the activity of regulatory proteins (Mayer and Bukau, 2005).…”

Section: Heat Shock Protein 70mentioning

confidence: 99%

Biological responses of feedlot cattle to heat load

Lees¹

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Heat load is a significant animal welfare and cost of production issue worldwide. In the US alone heat load is reported to have an annual economic burden of > $300 million in the beef sector.Furthermore animal growth is often depressed during summer resulting in heat related decreases in weight gain of approximately 10 kg which coincides with a 7 day increase in days on feed. The reduced growth rate increases days on feed, thereby increasing the cost of production. Whilst the effects of heat load on cattle has been researched for a number of years, there is speculation as to the interactions between hot environmental conditions and livestock performance, reproduction, health and overall wellbeing. Therefore there is a need to develop a more comprehensive understanding of the dynamic responses of animals to heat load. The key focus of heat load research is to develop effective management strategies to support animal comfort and performance during hot periods.While heat load can occur in pasture raised cattle, it is mostly observed within the intensive grain feed feedlot industry. Heat load occurs where a combination of environmental conditions exceed the animals ability to regulate body temperature, thus impacting on homeostasis. However how an animal responds to heat load is also dependent on a number of individual characteristics, including genotype, coat characteristics, health status and days on feed. Therefore no two animals will respond to hot climatic conditions in exactly the same manner. There are numerous responses to heat load that can be measured and/or observed in cattle, including changes in behaviour, respiratory dynamics, blood metabolites and body temperature. The experiments within this thesis were focused on investigating the; A key aspect in managing heat load is that feedlot personnel are able to recognise the responses of cattle to high heat load. Improvements in animal management have contributed to alleviating some of the negative effects of heat load. However summer conditions are still responsible for significant production losses and welfare concerns worldwide. Furthermore heat load cannot be completely eradicated where there are animal production operations in tropical and sub-tropical regions.Therefore the primary purpose of heat load research becomes focused on the effective use of mitigation strategies prior to and during heat related stress events, thus improving animal survivability and welfare during these events.iii Declaration by author Publications included in this thesisNo publications included. Contributions by others to the thesis

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A New SNP in the 3′-UTR of the hsp 70-1 Gene in Bos taurus and Bos indicus

Cited by 24 publications

References 8 publications

Cellular thermotolerance is associated with heat shock protein 70.1 genetic polymorphisms in Holstein lactating cows

Cellular thermotolerance is associated with heat shock protein 70.1 genetic polymorphisms in Holstein lactating cows

Metabolic and hormonal acclimation to heat stress in domesticated ruminants

Biological responses of feedlot cattle to heat load

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