A new set of BXD recombinant inbred lines from advanced intercross populations in mice

Peirce, Jeremy L.; Lu, Lu; Gu, Jing; Silver, Lee M.; Williams, Robert W.

doi:10.1186/1471-2156-5-7

Cited by 442 publications

(243 citation statements)

References 44 publications

(29 reference statements)

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“…In addition to the differential performance of B6 and D2 mice on tasks assessing the rewarding properties of psychostimulants, studies using these strains have shown gene-by-environment interactions on the propensity to self administer cocaine as a function of housing condition and maternal environment (van der Veen et al 2007(van der Veen et al , 2008 and amphetamine-induced conditioned place preference as a function of a brief period of food shortage (Cabib et al 2000). Finally, the B6 and the D2 strains are the progenitor strains for the BXD recombinant inbred (RI) panel, of which the BXD20 and BXD86 strains are part (Peirce et al 2004;Taylor et al 1977Taylor et al , 1999Williams et al 2001). The BXD RI panel has frequently been used to map complex polygenic traits (Chesler et al 2003;Philip et al 2010) including those directly related to the DA system (Boone et al 2008;Janowsky et al 2001;Jones et al 1999).…”

Section: Introductionmentioning

confidence: 99%

Genotype-dependent effects of adolescent nicotine exposure on dopamine functional dynamics in the nucleus accumbens shell in male and female mice: a potential mechanism underlying the gateway effect of nicotine

et al. 2011

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Section: Introductionmentioning

confidence: 99%

Genotype-dependent effects of adolescent nicotine exposure on dopamine functional dynamics in the nucleus accumbens shell in male and female mice: a potential mechanism underlying the gateway effect of nicotine

et al. 2011

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“…Several genetic reference panels of mice exist (Peirce et al 2004;Williams et al 2004;Grubb et al 2009;Bennett et al 2010). The latest is the Collaborative Cross (CC), a large panel of recombinant inbred lines derived from a genetically diverse set of eight inbred mouse strains (A/J, C57BL/6J, 129S1/SvImJ, NOD/LtJ, NZO/HiLtJ, CAST/EiJ, PWK/PhJ, and WSB/ EiJ).…”

Section: [Supplemental Materials Is Available For This Article]mentioning

confidence: 99%

Collaborative Cross mice and their power to map host susceptibility toAspergillus fumigatusinfection

Durrant¹,

Tayem²,

Yalcin³

et al. 2011

Genome Res.

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The Collaborative Cross (CC) is a genetic reference panel of recombinant inbred lines of mice, designed for the dissection of complex traits and gene networks. Each line is independently descended from eight genetically diverse founder strains such that the genomes of the CC lines, once fully inbred, are fine-grained homozygous mosaics of the founder haplotypes. We present an analysis of 120 CC lines, from a cohort of the CC bred at Tel Aviv University in collaboration with the University of Oxford, which at the time of this study were between the sixth and 12th generations of inbreeding and substantially homozygous at 170,000 SNPs. We show how CC genomes decompose into mosaics, and we identify loci that carry a deficiency or excess of a founder, many being deficient for the wild-derived strains WSB/EiJ and PWK/PhJ. We phenotyped 371 mice from 66 CC lines for a susceptibility to Aspergillus fumigatus infection. The survival time after infection varied significantly between CC lines. Quantitative trait locus (QTL) mapping identified genome-wide significant QTLs on chromosomes 2, 3, 8, 10 (two QTLs), 15, and 18. Simulations show that QTL mapping resolution (the median distance between the QTL peak and true location) varied between 0.47 and 1.18 Mb. Most of the QTLs involved contrasts between wild-derived founder strains and therefore would not segregate between classical inbred strains. Use of variation data from the genomes of the CC founder strains refined these QTLs further and suggested several candidate genes. These results support the use of the CC for dissecting complex traits.

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“…Several such panels have been or are being developed for a variety of species, including yeast, Drosophila (Ayroles et al 2009), Arabidopsis (Kover et al 2009), maize (Buckler et al 2009), Caenorhabditis elegans ( Johnson and Wood 1982;Li et al 2006;Rockman and Kruglyak 2009), and mice (Chesler et al 2008;Iraqi et al 2008;Morahan et al 2008). Efforts are also being made to expand (Peirce et al 2004) and maximize the potential of existing populations (Bennett et al 2010). In the construction of these populations, there is a unique opportunity to observe the impact of selection and inbreeding depression on the range of phenotypic diversity and genetic structure (Ayroles et al 2009;Rockman and Kruglyak 2009).…”

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Genetic analysis in the Collaborative Cross breeding population

Philip¹,

Sokoloff²,

et al. 2011

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Genetic reference populations in model organisms are critical resources for systems genetic analysis of disease related phenotypes. The breeding history of these inbred panels may influence detectable allelic and phenotypic diversity. The existing panel of common inbred strains reflects historical selection biases, and existing recombinant inbred panels have low allelic diversity. All such populations may be subject to consequences of inbreeding depression. The Collaborative Cross (CC) is a mouse reference population with high allelic diversity that is being constructed using a randomized breeding design that systematically outcrosses eight founder strains, followed by inbreeding to obtain new recombinant inbred strains. Five of the eight founders are common laboratory strains, and three are wild-derived. Since its inception, the partially inbred CC has been characterized for physiological, morphological, and behavioral traits. The construction of this population provided a unique opportunity to observe phenotypic variation as new allelic combinations arose through intercrossing and inbreeding to create new stable genetic combinations. Processes including inbreeding depression and its impact on allelic and phenotypic diversity were assessed. Phenotypic variation in the CC breeding population exceeds that of existing mouse genetic reference populations due to both high founder genetic diversity and novel epistatic combinations. However, some focal evidence of allele purging was detected including a suggestive QTL for litter size in a location of changing allele frequency. Despite these inescapable pressures, high diversity and precision for genetic mapping remain. These results demonstrate the potential of the CC population once completed and highlight implications for development of related populations.

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A new set of BXD recombinant inbred lines from advanced intercross populations in mice

Cited by 442 publications

References 44 publications

Genotype-dependent effects of adolescent nicotine exposure on dopamine functional dynamics in the nucleus accumbens shell in male and female mice: a potential mechanism underlying the gateway effect of nicotine

Genotype-dependent effects of adolescent nicotine exposure on dopamine functional dynamics in the nucleus accumbens shell in male and female mice: a potential mechanism underlying the gateway effect of nicotine

Collaborative Cross mice and their power to map host susceptibility toAspergillus fumigatusinfection

Genetic analysis in the Collaborative Cross breeding population

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