A New Sesquiterpene Lactone with Analgesic Activity from Helenium amarum (Raf.) H. Rock

Having Fun with The Nozoe Autograph Books. A Bit of Exploration and an Unexpected Learning Experience

“…The first signee I noticed was Howard J. Lucas (page 59; November 22, 1953) ( Figure 2). What was Lucas, 68 years old at the time, a heavy hitter on Caltech's faculty, author of the widely regarded text Organic Chemistry [4] published in 1935, a member of the National Academy of Sciences, the Ph.D. advisor of many eminent chemists including Bill Young and Saul Winstein, doing in quiet Hawaii in 1953? According to his biography, he was a visiting professor at the University of Hawaii in 1953 and a visiting professor at Ohio State University in 1954-1955, becoming emeritus professor at Caltech in 1955.…”

Antitumor Agents: Structure-Activity Relationships in Tenulin Series

“…Isotenulin (VI), prepared from tenulin by a literature method (3), yielded dihydroisotenulin (VII) (6) upon catalytic hydrogenation and 2.3-epoxyisotenulin (VIII) (6) when briefly exposed to cold, basic hydrogen peroxide solution. 2,3-Epoxyisotenulin, Cl7H2206.…”

“…Epoxyisotenulin (VIII)-2,3-Epoxyisotenulin was prepared in 74% yield from VI by the method of Lucas et a( (6),. who obtained the product as an amorphous glass.…”

Detailed 1H and 13C NMR structural assignments of four sesquiterpene lactones isolated from Eremanthus elaeagnus (Asteraceae)

“…[1][2][3][4][5][6] SLs include a variety of carbocyclic skeletons that display different biologically active chemical structures, as reported by papers published since the 1960s, when the first SLs were isolated. [7][8][9][10] Several SLs were isolated prior to the introduction of nuclear magnetic resonance (NMR) methodologies, which are related to the parallel development of new techniques and equipment evolution, such as highfield magnet, inverse detection, pulse field gradient, and new pulse sequences. Thus, published data from this era were found to be incomplete, inaccurate, or even wrong.…”