A new series of thiazolyl pyrazoline derivatives linked to benzo[1,3]dioxole moiety: Synthesis and evaluation of antimicrobial and anti-proliferative activities

Mansour, Eman A.; Aboelnaga, Asmaa; Nassar, Ekhlass; Elewa, Safaa I.

doi:10.1080/00397911.2019.1695839

Cited by 24 publications

(38 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…26 In addition, a variety of derivatives demonstrated diverse biological activities such as antimicrobial ( VI , Fig. 1), 17,27 antiprotozoal 28,29 anti-proliferative, 27,30,31 and anti-Alzheimer 32 activities.…”

Section: Introductionmentioning

confidence: 99%

Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens

et al. 2022

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens

et al. 2022

View full text Add to dashboard Cite

show abstract

“…Various organic mixtures (consisting of a heterocyclic setup) actively play a crucial role in existing conditions. Derivatives of heterocyclic thiazine are biologically present in biomolecules, which exhibit antimycotic and antiviral properties as well as a growth regulators [24]. Changes in the protein content and late embryogenic abundant protein formation due to priming treatment makes seeds more efficient and able to tolerate the drought [25].…”

Section: Introductionmentioning

confidence: 99%

Deciphering Plantago ovata Forsk Leaf Extract Mediated Distinct Germination, Growth and Physio-Biochemical Improvements under Water Stress in Maize (Zea mays L.) at Early Growth Stage

et al. 2021

View full text Add to dashboard Cite

Use of Plantago ovata Forsk leaf (also known as blond plantain or isabgol) extract is a novel approach for ameliorating water stress in various agronomic crops such as maize (Zea mays L.). To examine the potential roles of P. ovata extract (0, 20 and 40%) in increasing seed germination, plant growth, photosynthetic measurements, stomatal properties, oxidative stress and antioxidant response, ions uptake and the relationship between studied parameters, we investigated the impacts of its short-term seed priming on Z. mays L. elite cultivar “Cimmyt-Pak” under a control environment and a water deficit stress environment (induced by PEG). It was evident that water deficit stress conditions induced a negative impact on plant growth, stomatal properties and ion uptake in different organs of Z. mays. The decrease in growth-related attributes might be due to overproduction of oxidative stress biomarkers, i.e., malondialdehyde (MDA) contents, hydrogen peroxide (H2O2) initiation, and electrolyte leakage (%), which was also overcome by the enzymatic antioxidants, i.e., superoxidase dismutase (SOD), peroxidase (POD), catalase (CAT) and ascorbate peroxidase (APX) and non-enzymatic antioxidants, which increased under the water stress environment. However, seed priming with P. ovata extract positively increased germination rate and growth profile, and protected photosynthetic apparatus and stomatal properties by decreasing oxidative stress indicators and increasing activities of antioxidant compounds. Our results also depicted that the optimum concentration of P. ovata extract for Z. mays seedlings under water stress conditions was 20%, while a further increase in P. ovata extract (40%) induced a non-significant negative impact on growth and biomass of Z. mays seedling. In addition, the effect was more promising on Z. mays seedlings when grown under controlled conditions. Here, we concluded that the understanding of the role of seed priming with P. ovata extract in the increment of growth-related attributes, photosynthetic apparatus (Pn, Gs, Ts and Ci) and nutrient uptake (Ca2+, Fe2+, P and Mg2+) introduces new possibilities for their effective use in water deficit stress environments and shows a promising foundation for Z. mays tolerance against water deficit stress conditions.

show abstract

“…Two novel chalcones, prop‐2‐en‐1‐ones ( 88 a – b ), were synthesized by condensing the naphthyl ketone ( 87 a – b ) with piperonal ( 86 ) followed by treatment with thiosemicarbazide in refluxing ethanol in the presence of NaOH giving thioamide derivatives ( 89 a – b ) (Scheme 23). The thioamide derivatives were reacted with different compounds to yield various benzylidene thiazole and thiazolyl‐pyrazoline derivatives [84] . (Scheme 23)…”

Section: Chemistry Of Chalcone Derived Pyrazoline Derivativesmentioning

confidence: 99%

“…The compound ( 94 c ) (Ar=NHPh) was found to exhibit the most active antifungal derivative (IC 50 =0.25 mg/mL) against A.funigatus , and the compound ( 93 c ) (Ar=4−Me−C 6 H 4 ) had got the highest inhibitory activity against S.aureus with MIC value as 2.1 mg/mL. The compound ( 94 c ) (Ar=NHPh) was also found to exhibit anti‐cancer against HCT‐116 cancer with IC 50 value of 6.19 μM [84] …”

Section: Chemistry Of Chalcone Derived Pyrazoline Derivativesmentioning

confidence: 99%

An Overview on Synthesis and Biological Activity of Chalcone Derived Pyrazolines

2021

View full text Add to dashboard Cite

Chalcones are α, β unsaturated aromatic ketones having enone moiety and exhibit a wide array of pharmaceutical and biological activities. Chalcones possess a wide range of biological activities such as anticancer, antituberculosis, antidiabetic, antioxidant, anti‐inflammatory, antimicrobial, and antimalarial. Nitrogen‐containing heterocyclic compounds are an extremely important class of organic compounds with a broad spectrum of pharmaceutical activities. Pyrazolines are N‐ heterocyclic compounds that exhibit a wide range of pharmaceutical activities and are synthesized from chalcone with enhanced biological activity. The present study summarizes the chemistry of various chalcone‐based pyrazolines and their derivatives with the available data till 2021.

show abstract

A new series of thiazolyl pyrazoline derivatives linked to benzo[1,3]dioxole moiety: Synthesis and evaluation of antimicrobial and anti-proliferative activities

Cited by 24 publications

References 37 publications

Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens

Development of novel isatin thiazolyl-pyrazoline hybrids as promising antimicrobials in MDR pathogens

Deciphering Plantago ovata Forsk Leaf Extract Mediated Distinct Germination, Growth and Physio-Biochemical Improvements under Water Stress in Maize (Zea mays L.) at Early Growth Stage

An Overview on Synthesis and Biological Activity of Chalcone Derived Pyrazolines

Contact Info

Product

Resources

About