A new scleroglucan/borax hydrogel: swelling and drug release studies

Coviello, Tommasina; Grassi, Mario; Palleschi, Antonio; Bocchinfuso, Gianfranco; Coluzzi, Gina; Banishoeib, Fateme; Alhaique, Franco

doi:10.1016/j.ijpharm.2004.10.025

Cited by 56 publications

(31 citation statements)

References 23 publications

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“…In previous works [24], it was reported that tablets, prepared with the GG/borax freeze-dried hydrogel, undergo an anomalous peculiar swelling, essentially along one direction and very similar to that reported for the Scleroglucan/borax tablets [1, 25–27]. New tablets were then prepared with sonicated GG samples, and water uptake and elongation behaviour were followed as a function of time.…”

Section: Resultssupporting

confidence: 58%

Sonication-Based Improvement of the Physicochemical Properties of Guar Gum as a Potential Substrate for Modified Drug Delivery Systems

Ansari

Matricardi

Cencetti

et al. 2013

BioMed Research International

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Guar Gum is a natural polysaccharide that, due to its physicochemical properties, is extensively investigated for biomedical applications as a matrix for modified drug delivery, but it is also used in the food industry as well as in cosmetics. A commercial sample of Guar Gum was sonicated for different periods of time, and the reduction in the average molecular weight was monitored by means of viscometric measurements. At the same time, the rheological behaviour was also followed, in terms of viscoelasticity range, flow curves, and mechanical spectra. Sonicated samples were used for the preparation of gels in the presence of borate ions. The effect of borax on the new samples was investigated by recording mechanical spectra, flow curves, and visible absorption spectra of complexes with Congo Red. The anisotropic elongation, observed in previous studies with tablets of Guar Gum and borax, was remarkably reduced when the sonicated samples were used for the preparation of the gels.

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Section: Resultssupporting

confidence: 58%

Sonication-Based Improvement of the Physicochemical Properties of Guar Gum as a Potential Substrate for Modified Drug Delivery Systems

Ansari

Matricardi

Cencetti

et al. 2013

BioMed Research International

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“…In the last decade, by using both experimental and computational techniques, we investigated the drug release properties of tablets formed by Sclg, also in the presence of borax [3,5,[16][17][18][19][20][21]. During the water uptake process, a gel phase forms and the release of the drugs is related to their diffusion into the gel.…”

Section: Introductionmentioning

confidence: 99%

Relative Stability of the Scleroglucan Triple-Helix and Single Strand: an Insight from Computational and Experimental Techniques

Bocchinfuso

Meisina

Conflitti

et al. 2016

Zeitschrift Für Physikalische Chemie

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Scleroglucan (Sclg) is a polysaccharide that exhibits a triple helix conformation (triplex), both in aqueous solution and in the solid state, which is lost in DMSO solution, at high temperature and at high pH values. The triplex conformation is characterized by a high rigidity, responsible of Sclg peculiar properties. Although the relative stability of triplex and single strand has already been investigated, different structural details are still missing. In the present study, we analyse the structural properties and the factors stabilizing the single chain and the triple helix of Sclg in different conditions. To this end, we simulated both systems in water and in DMSO. The triple helix has been also simulated in the presence of chemical damages on one of the three strands (to reproduce in silico the effect of sonication) or by inducing a partial unfolding of the triplex structure. The computational results have been compared with experimental evidences in which the triplex denaturation, at alkaline pH values, has been followed by monitoring the UV and CD spectra of Congo red, used as a probe molecule. Our results indicate that sonication breaks the Sclg chains without appreciably changing the stability of the other tracts of triple helix. The simulated perturbed or partially unfolded triplexes show a clear tendency to form less Unauthenticated Download Date | 6/23/16 1:58 PM 2 | G. Bocchinfuso et al. ordered aggregates. Finally, our simulations put in evidence an important role of the hydrophobic interactions both in the triplex stability and in the aggregation processes observed after induced denaturation.

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“…The main advantages of natural polymers are that they are biocompatible, biodegradable and produce no systemic toxicity on administration [2]. Numerous hydrophilic polymers, and in particular polysaccharides, as well as their derivatives, have been proposed for the formulation of modified-release dosage forms [3]. Alginates, natural hydrophilic polysaccharide derived from seaweed, consist of 1→4, linked D-mannuronic acid and Lglucuronic acid residues arranged as blocks of either type of unit or as a random distribution of each type.…”

Section: Introductionmentioning

confidence: 99%

Sodium alginate microspheres for extending drug release: formulation and in vitro evaluation.

Soni¹,

Kumar²,

Namdeo³

2010

Int. J. Drug Delivery

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In the present study, spherical microspheres of theophylline (TP) using sodium alginate as the hydrophilic carrier were prepared to prolong the release. The shape, surface and size characteristics were determined by scanning electron microscopy. The microspheres were found to be discreet and spherical in shape and had a smoother surface. The mean diameter of seven alginate microspheres formulations were between 7.6 ± 0.52 and 22.35 ±0.31 μm. It was observed that mean particle size of the microspheres increased with an increase in the concentration of polymer. The entrapment efficiency was found to be in the range of 70-93%. Optimized alginate microspheres were found to possess good sphericity, size and adequate entrapment efficiency. The in vitro release studies were carried out in pH progression media (pH 1.2, 2.5, 4.5, 7 and 7.4 solutions). Results indicated that percent drug release decreased with an increased alginate concentration. TP-loaded Alginate microspheres showed extended in vitro drug release thus use of microspheres potentially offers sustained release profile along with improved delivery of TP.

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A new scleroglucan/borax hydrogel: swelling and drug release studies

Cited by 56 publications

References 23 publications

Sonication-Based Improvement of the Physicochemical Properties of Guar Gum as a Potential Substrate for Modified Drug Delivery Systems

Sonication-Based Improvement of the Physicochemical Properties of Guar Gum as a Potential Substrate for Modified Drug Delivery Systems

Relative Stability of the Scleroglucan Triple-Helix and Single Strand: an Insight from Computational and Experimental Techniques

Sodium alginate microspheres for extending drug release: formulation and in vitro evaluation.

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