“…It has been extensively investigated since the 1960s because of the anticancer, 1,2 antimicrobial and antifungal, 3 anti-inflammatory, 4 and insectidal potential, 5 and hepatoprotective properties 6 of the plant extracts. Earlier studies on this plant have disclosed the presence of alkaloids, 7 fatty acids, 8 flavonoids, 9 -12 lignans, 13 steroids, 14,15 diterpenoids, 16 sesquiterpenoids, 17 triterpenoids, 1,18 -20 and a series of complex tetranortriterpenoids (limonoids) (including dihydroamoorinin 21 and amoorinin, 22 and its glucosides, 9 aphanamixinin, 18 kihadalactone and polystachin, 23 rohituka 1-9, 24 -26 rohituka 12-14, 23 and rohitukin 27 ). Our early work on investigating the chemical constituents of the plant seed resulted in the isolation of a known dregeana-1 (2) and a novel limonoid rohituka-15 (3).…”