A new route for the synthesis of [18F]fluoroaromatic substituted amino acids: No carrier added fluorophenylalanine

Synthesis of 4‐dihydroxyboryl‐2‐[18F]fluorophenylalanine with relatively high‐specific activity

“…12 This approach has been applied, for example, in the multistep synthesis of radiofluorinated phenylalanine (FPhe) 13 and DOPA.…”

Comparison of pathways to the versatile synthon of no‐carrier‐added 1‐bromo‐4‐[18F]fluorobenzene

“…Former studies of a direct nucleophilic aromatic substitution reaction using an 18 F-for-halide exchange showed contradicting results. 20,21 Therefore, as depicted in pathway B, a nucleophilic exchange reaction was examined using halides simultaneously as weak activating and leaving group. 29 when investigating the dimethylsulfonium group as a leaving group for nucleophilic aromatic 18 F-fluorination reactions.…”

Synthesis of 18F‐labelled stilbenes from 4‐[18F]fluorobenz‐aldehyde using the Horner–Wadsworth–Emmons reaction

“…5 Other C-H acidic phosphorous-containing compounds have been coupled with 18 F-labelled aldehydes according to Wittig-type reactions giving reasonable radiochemical yields of a mixture of E/Z-isomers. 6 The coupling of phosphonic acid esters with carbonyl compounds, also referred to as the Horner-WadsworthEmmons reaction, represents another powerful carbonyl olefination reaction successfully applied for a long time in organic synthesis.…”