A new role for PGRP-S (Tag7) in immune defense: lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1

Dukhanina, E. A.; Lukyanova, Tamara I.; Romanova, E. A.; Guerriero, Vince; Гнучев, Н. В.; Georgiev, G. P.; Yashin, Denis V.; Sashchenko, Lidia P.

doi:10.1080/15384101.2015.1104440

Cited by 28 publications

(28 citation statements)

References 33 publications

(45 reference statements)

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“…Since JUNB is associated with lipid metabolism, high expression of JUNB was expected in activated cells. S100A4, which is associated with the development and progression of the tumor and immune infiltration (34,35), exhibited high expression in in vivo epithelial cells and T cells, but low expression in in vitro cell lines ( Fig. 3D and E).…”

Section: Identification Of Significant Differences In Gene Expressionmentioning

confidence: 99%

Tracking the important role of JUNB in hepatocellular carcinoma by single‑cell sequencing analysis

Peng

Zhou

et al. 2019

Oncol Lett

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Hepatocellular carcinoma (HCC) is the most commonly diagnosed liver cancer, accounting for ~90% of all primary malignancy of the liver. Although various medical treatments have been used as systemic therapies, patient survival time may be extended by only a few months. Moreover, the underlying mechanisms of HCC development and progression remain poorly understood. In the present study, the single-cell transcriptome of one in vivo HCC tumor sample, two in vitro HCC cell lines and normal peripheral blood mononuclear cells were analysed in order to identify the potential mechanism underlying the development and progression of HCC. Interestingly, JunB proto-oncogene was identified to serve a role in the immune response and in development and progression of HCC, potentially contributing to the development of novel therapeutics for HCC patients.

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Section: Identification Of Significant Differences In Gene Expressionmentioning

confidence: 99%

Tracking the important role of JUNB in hepatocellular carcinoma by single‑cell sequencing analysis

Peng

Zhou

et al. 2019

Oncol Lett

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“…Most researchers focus on the antibacterial role of this protein in immune response [19]. We have studied the antitumor effect of this protein and have demonstrated that the complex formed between Tag7 and Mts1 protein can cause migration of immune cells [20], and can induce activation of lymphocytes, pointing to the Tag7 antitumor activity [21]. Another important function of Tag7 protein is its interaction with the heat shock protein Hsp70.…”

Section: Introductionmentioning

confidence: 99%

A 12-mer Peptide of Tag7 (PGLYRP1) Forms a Cytotoxic Complex with Hsp70 and Inhibits TNF-Alpha Induced Cell Death

Романова

Sharapova

Telegin

et al. 2020

Cells

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Investigation of interactions between a pro-inflammatory cytokine tumor necrosis factor (TNFα) and its receptor is required for the development of new treatments for autoimmune diseases associated with the adverse effects of TNFα. Earlier, we demonstrated that the innate immunity protein Tag7 (PGRP-S, PGLYRP1) can interact with the TNFα receptor, TNFR1, and block the transduction of apoptotic signals through this receptor. A complex formed between the Tag7 protein and the major heat shock protein Hsp70 can activate TNFR1 receptor and induce tumor cell death via either apoptotic or necroptotic pathway. In this study, we show that a 12-mer peptide, designated 17.1, which was derived from the Tag7 protein, can be regarded as a novel TNFα inhibitor, also is able to form a cytotoxic complex with the heat shock protein Hsp70. This finding demonstrates a new role for Hsp70 protein in the immune response. Also, this new inhibitory 17.1 peptide demonstrates an anti-inflammatory activity in the complete Freund’s adjuvant (CFA)-induced autoimmune arthritis model in laboratory mice. It appears that the 17.1 peptide could potentially be used as an anti-inflammatory agent.

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“…More recent research indicates that mammalian PGLYRPs may also have immunomodulatory functions which are independent of their bactericidal or enzymatic properties ( Dziarski and Gupta, 2010 ). These immune modulatory functions were suggested to be even more important than direct antibacterial effects of these proteins, because (i) the direct antimicrobial functions are often inhibited by physiological concentrations of, e.g., salt and proteins, (ii) the relatively high dosage needed for antimicrobial activity is often not reached in the in vivo situation and (iii) immune modulation and antimicrobial functions can be mediated via independent mechanisms as seen for PGLYRPs where non-bactericidal immune modulatory PGLYRPs were expressed by E. coli ( De Marzi et al, 2015 ; Dukhanina et al, 2015 ; Hancock et al, 2016 ). For example, PGLYRP3 enhances phagocytosis and the pro-inflammatory response to peptidoglycan (PGN) in THP-1 cells ( De Marzi et al, 2015 ).…”

Section: Introductionmentioning

confidence: 99%

Peptidoglycan Recognition Protein 3 Does Not Alter the Outcome of Pneumococcal Pneumonia in Mice

et al. 2018

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Pneumococci frequently cause community-acquired pneumonia, a disease with high mortality rates, particularly in young children and in the elderly. Endogenous antimicrobial peptides and proteins such as PGLYRP3 may contribute to the progression and outcome of this disease. Since increasing antibiotic resistant strains occur all over the world, these endogenous antimicrobial molecules are interesting new targets for future therapies. In this study, the expression pattern of PGLYRP3 was analyzed in alveolar epithelial cells, alveolar macrophages and neutrophils. Additionally, the function of PGLYRP3 during Streptococcus pneumoniae-induced pneumonia was investigated in a murine pneumococcal pneumonia model using PGLYRP3KO mice. PGLYRP3 is expressed in all selected cell types but pneumococcus-dependent induction of PGLYRP3 was observed only in neutrophils and alveolar macrophages. Interestingly, there were no significant differences in the bacterial loads within the lungs, the blood or the spleens, in the cytokine response, the composition of immune cells and the histopathology between wild type and PGLYRP3KO mice. Finally, we could neither observe significant differences in the clinical symptoms nor in the overall survival. Collectively, PGLYRP3 seems to be dispensable for the antibacterial defense during pneumococcal pneumonia.

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A new role for PGRP-S (Tag7) in immune defense: lymphocyte migration is induced by a chemoattractant complex of Tag7 with Mts1

Cited by 28 publications

References 33 publications

Tracking the important role of JUNB in hepatocellular carcinoma by single‑cell sequencing analysis

Tracking the important role of JUNB in hepatocellular carcinoma by single‑cell sequencing analysis

A 12-mer Peptide of Tag7 (PGLYRP1) Forms a Cytotoxic Complex with Hsp70 and Inhibits TNF-Alpha Induced Cell Death

Peptidoglycan Recognition Protein 3 Does Not Alter the Outcome of Pneumococcal Pneumonia in Mice

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