A new role for inflammasomes: sensing the disturbances in non-alcoholic fatty liver disease

Desai, Poorvi; Parthasarathy, Prasanna Tamarapu; Galam, Lakshmi; Lockey, Richard F.; Kolliputi, Narasaiah

doi:10.3389/fphys.2013.00156

Cited by 13 publications

(3 citation statements)

References 14 publications

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“…Potential markers are CXCR4 expression and endo-lysosomal pH profiles. Measuring pH through the endocytic pathway has been attempted, however, the accuracy of measurements is low owing to proteins interfering with the behaviour of pH-sensitive fluorophores [109]. Nevertheless, broad knowledge of these pH changes could be useful in selecting or designing delivery systems for specific patients.…”

Section: (A) Targeting Specific Cell Types Diseases and Environmentsmentioning

confidence: 99%

Using macropinocytosis for intracellular delivery of therapeutic nucleic acids to tumour cells

Desai

Hunter

Kapustin

2018

Phil. Trans. R. Soc. B

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Section: (A) Targeting Specific Cell Types Diseases and Environmentsmentioning

confidence: 99%

Using macropinocytosis for intracellular delivery of therapeutic nucleic acids to tumour cells

Desai

Hunter

Kapustin

2018

Phil. Trans. R. Soc. B

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“…Non-alcoholic fatty liver disease (NAFLD) is one of the manifestations of metabolic syndrome, that include hypertension, diabetes, excess body fat around the waist or abnormal cholesterol levels that can predispose to heart disease, diabetes, and stroke [ 1 ].…”

Section: Introductionmentioning

confidence: 99%

New Era for Usage of Serum Liver Enzymes as A Promising Horizon for the Prediction of Non-Alcoholic Fatty Liver Disease

Salman¹,

Abo-Elfadl²,

Heagzy³

2016

Open Access Maced J Med Sci

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BACKGROUND:Liver histology remains the gold standard for assessing non-alcoholic fatty liver disease (NAFLD). Noninvasive serological markers and radiological methods have been developed to evaluate steatosis to avoid biopsy.AIM:To put cutoff value for liver enzymes that could predict non-alcoholic steatohepatitis (NASH).PATIENTS AND METHODS:This study was conducted on 54 patients (with NAFLD diagnosed by the US). Patients were subjected to history, physical, anthropometric measurements, investigations including liver enzymes, abdominal US, and liver biopsy. According to biopsy results, patients were subdivided according to NASH development. Also, biopsy results were correlated to the levels of liver enzymes.RESULTS:Forty-seven patients who were suspected to have NAFLD by sonar were confirmed by biopsy. There was a significant correlation between steatosis degree in biopsy and sonar. Correlation study between steatosis in biopsy and ALT level showed highly significant positive correlation. Correlation study between steatosis in biopsy on one side & AST and GGT on the other side showed significant positive correlation. Cutoff value for detection of NASH using ALT & AST & and GGT were 50.5, 56, 60.5 respectively with sensitivity = 95.5, 90.5, 86.4 % and specificity = 93.8, 100, 87.5%.CONCLUSION:Cut off values of liver enzymes can be combined with abdominal sonar to predict NASH.

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“…Nonalcoholic fatty liver disease (NAFLD) is a manifestation of metabolic syndrome, a group of conditions including hypertension, high plasma glucose, excess body fat around waist or abnormal cholesterol levels, which will work together to increase the risk of heart disease, diabetes, and stroke. 1 In obese and overweight individuals, NAFLD prevalence can be as high as 70%. The pathological spectrum of NAFLD ranges from simple hepatic steatosis to more severe manifestations, such as nonalcoholic steatohepatitis (NASH), hepatic fibrosis and cirrhosis.…”

Section: Introductionmentioning

confidence: 99%

Serum Resistin Level and Its Receptor Gene Expression in Liver Biopsy as Predictors for the Severity of Nonalcoholic Fatty Liver Disease

Hegazy¹,

Abo-Elfadl²,

Mostafa³

et al. 2014

EJOHG

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Background Liver histology remains the gold standard for assessing nonalcoholic fatty liver disease (NAFLD). Noninvasive serological markers have been developed to evaluate steatosis to avoid biopsy. In NAFLD patients, serum resistin was higher than those in control lean and obese patients.Objective of the study To investigate serum resistin and its receptor gene expression in liver biopsy as predictors for NAFLD severity.Patients and methods This study was conducted on 54 obese patients, with suspected fatty liver by ultrasound (excluding diabetic, alcoholic, hepatitis C virus antibody (HCVAb) or hepatitis B surface antigen (HBsAg) positive patients). They were subjected to anthropometric measurements, laboratory studies including serum resistin, abdominal ultrasonography (US) and liver biopsy. The 15 lean subjects were included as a control group. According to biopsy results, patients were subdivided into nonalcoholic steatohepatitis (NASH) group (46 patients) and non-NASH group (8 patients).Results Significantly higher levels of resistin were detected in NAFLD patients compared to control subjects (p = 0.0001). Also, higher levels of resistin were recorded in NASH group compared to the non-NASH group; however, the difference was not statistically significant (p = 0.584). Serum alanine aspirate aminotransferase (AST), alanine aminotransferase (ALT) and gamma-glutamyl transpeptidase (GGT) were higher in NASH patients than non-NASH group (p = 0.223, p = 0.005 and p = 0.006 respectively). Abdominal US showed high sensitivity in NAFLD diagnosis (sensitivity of sonar in detecting steatosis grade compared to biopsy was 61% in grade 1, 25% in grade 2 and 75% in grade 3).Conclusion Serum resistin can be combined with other noninvasive markers to predict the presence of NASH as an alternative to liver biopsy.How to cite this article: Hegazy M, Abo-Elfadl S, Mostafa A, Ibrahim M, Rashed L, Salman A. Serum Resistin Level and Its Receptor Gene Expression in Liver Biopsy as Predictors for the Severity of Nonalcoholic Fatty Liver Disease. Euroasian J Hepato-Gastroenterol 2014;4(2):59-62.

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A new role for inflammasomes: sensing the disturbances in non-alcoholic fatty liver disease

Cited by 13 publications

References 14 publications

Using macropinocytosis for intracellular delivery of therapeutic nucleic acids to tumour cells

Using macropinocytosis for intracellular delivery of therapeutic nucleic acids to tumour cells

New Era for Usage of Serum Liver Enzymes as A Promising Horizon for the Prediction of Non-Alcoholic Fatty Liver Disease

Serum Resistin Level and Its Receptor Gene Expression in Liver Biopsy as Predictors for the Severity of Nonalcoholic Fatty Liver Disease

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