A new retrospective, multi‐evidence veterinary drug screening method using drift tube ion mobility mass spectrometry

Xu, Zhenzhen; Li, Jianzhong; Chen, Ailiang; Ma, Xin; Yang, Shi‐Yao

doi:10.1002/rcm.8154

Cited by 12 publications

(3 citation statements)

References 28 publications

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“…As IM‐MS devices are not yet very widespread, such coupled platforms have so far only been used to a limited extent for food analysis. A large part of the published study is more target‐based and focuses on certain analyte groups, such as mycotoxins [139], pesticides [140], and veterinary drugs [141]. Nontargeted studies were conducted during the roasting process of coffee [142], characterization of wine [143] and ginseng [144], and species/varietal differentiation of truffles [12] and potatoes [11].…”

Section: Ion Mobility Spectrometrymentioning

confidence: 99%

Food metabolomics: Latest hardware—developments for nontargeted food authenticity and food safety testing

Creydt¹,

Fischer²

2022

Electrophoresis

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The analytical requirements for food testing have increased significantly in recent years. On the one hand, because food fraud is becoming an ever-greater challenge worldwide, and on the other hand because food safety is often difficult to monitor due to the far-reaching trade chains. In addition, the expectations of consumers on the quality of food have increased, and they are demanding extensive information. Cutting-edge analytical methods are required to meet these demands. In this context, non-targeted metabolomics strategies using mass and nuclear magnetic resonance spectrometers (mass spectrometry [MS]) have proven to be very suitable. MS-based approaches are of particular importance as they provide a comparatively high analytical coverage of the metabolome.Accordingly, the efficiency to address even challenging issues is high. A variety of hardware developments, which are explained in this review, have contributed to these advances. In addition, the potential of future developments is highlighted, some of which are currently not yet commercially available or only used to a comparatively small extent but are expected to gain in importance in the coming years.

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Section: Ion Mobility Spectrometrymentioning

confidence: 99%

Food metabolomics: Latest hardware—developments for nontargeted food authenticity and food safety testing

Creydt¹,

Fischer²

2022

Electrophoresis

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“…LODs were consequently improved up to 25 and 42.5-fold when applying FAIMS–ESI–MS instead of ESI–MS/MS or ESI–MS, respectively. Despite the characteristic of ion filtering is usually assigned to FAIMS/DMS technology, DTIMS and TWIMS are also able to isolate analyte signals from chemical background, improving concentration sensitivity [30,103]. In the context of chemical food safety, signal to noise ratio (S/N) of LC–ESI–ToF–MS methods intended to monitoring steroids and their metabolites in livestock were increased between 2 and 7 fold by the integration of TWIMS in the analytical workflow (Figure 5) [30].…”

Section: Applications Of Ims In Food Analysismentioning

confidence: 99%

Ion Mobility Spectrometry in Food Analysis: Principles, Current Applications and Future Trends

et al. 2019

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In the last decade, ion mobility spectrometry (IMS) has reemerged as an analytical separation technique, especially due to the commercialization of ion mobility mass spectrometers. Its applicability has been extended beyond classical applications such as the determination of chemical warfare agents and nowadays it is widely used for the characterization of biomolecules (e.g., proteins, glycans, lipids, etc.) and, more recently, of small molecules (e.g., metabolites, xenobiotics, etc.). Following this trend, the interest in this technique is growing among researchers from different fields including food science. Several advantages are attributed to IMS when integrated in traditional liquid chromatography (LC) and gas chromatography (GC) mass spectrometry (MS) workflows: (1) it improves method selectivity by providing an additional separation dimension that allows the separation of isobaric and isomeric compounds; (2) it increases method sensitivity by isolating the compounds of interest from background noise; (3) and it provides complementary information to mass spectra and retention time, the so-called collision cross section (CCS), so compounds can be identified with more confidence, either in targeted or non-targeted approaches. In this context, the number of applications focused on food analysis has increased exponentially in the last few years. This review provides an overview of the current status of IMS technology and its applicability in different areas of food analysis (i.e., food composition, process control, authentication, adulteration and safety).

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“…GC-MS is unsuitable for the detection of volatile, highly polar, and pyrolytic compounds. The most commonly used methods for detecting multi-residues in animal food sources include UPLC-MS/MS, UPLC-QE, and UPLC-QTOF (Xu et al 2018). Steven used UPLC-MS/MS to detect 62 veterinary drug residues in the bovine kidney, with a recovery rate of 70% and a repeatability of less than 25% (Steven et al 2012).…”

mentioning

confidence: 99%

Screening and Analysis of Multiclass Veterinary Drug Residues in Animal Source Foods using UPLC-Q-Exactive Orbitrap/MS

Zhao

Jiang

Guo

et al. 2021

Bull Environ Contam Toxicol

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A rapid, simple, and sensitive method of detecting veterinary drug residues in animal food sources, including poultry and pork, was developed and validated. The method was optimized for over 155 veterinary drugs of 21 different classes. Sample pretreatment included a simple solid-liquid extraction step with 0.2% formic acid-acetonitrile-water and a purification step with a PRiME HLB (hydrophile-lipophile balance) solid-phase extraction cartridge. Data were collected using ultra-high-performance liquid chromatography coupled to Quadrupole-Exactive Orbitrap mass spectrometry. The limits of detection of 155 veterinary drugs ranged from 0.1 µg/kg to 10 µg/kg. The recovery rates were between 79.2 and 118.5 % in all matrices studied, with relative standard deviation values less than 15% (n = 6). The evaluated method allows the reliable screening, quantification, and identification of 155 veterinary drug residues in animal source food and has been successfully applied in authentic samples.

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A new retrospective, multi‐evidence veterinary drug screening method using drift tube ion mobility mass spectrometry

Abstract: A new retrospective, multi-evidence platform was built for veterinary drug screening in a single experiment. The sensitivity was significantly improved and the data can be used for quantification. The platform showed its potential to be used for food safety and risk assessment.

Cited by 12 publications

References 28 publications

Food metabolomics: Latest hardware—developments for nontargeted food authenticity and food safety testing

Food metabolomics: Latest hardware—developments for nontargeted food authenticity and food safety testing

Ion Mobility Spectrometry in Food Analysis: Principles, Current Applications and Future Trends

Screening and Analysis of Multiclass Veterinary Drug Residues in Animal Source Foods using UPLC-Q-Exactive Orbitrap/MS

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