Abstract.We have developed and reported super-high resolution liquid crystal displays (SHR-LCDs) using a new resolution enhancement technology of the independent sub-pixel driving (ISD) that utilizes three sub-pixels contained in each pixel element. This technology realizes the three-times resolution enhancement of monochrome LCDs. A 15 mega-pixel (MP) SHR-LCD out of a 5MP LCD and a 9MP SHR-LCD out of a 3MP LCD, for example, are realized by this technology, which improves the depiction ability of detailed image shapes such as micro-calcifications of a mammography. Furthermore, the ISD technology brings not only resolution enhancement but also noise reduction effect by the high-frequency data sampling in displaying the clinical images. In this study, we have investigated the clinical efficacy of the SHR-LCDs by means of phantom observation studies and blind observer comparison studies using clinical mammography images performed by radiologists. We used a conventional 5MP LCD for a comparison of a 15MP SHR-LCD and a 9MP SHR-LCD to evaluate their efficacy. From the results of the studies, it was indicated that the SHR-LCDs using the ISD technology had the excellent ability to display the high-resolution digital mammography images.