A new reagent for efficient synthesis of nitriles from aldoximes using methoxymethyl bromide

Abstract

This study outlines an efficient, high-yielding, and rapid method by which to access diverse nitriles from aldoximes with methoxymethyl bromide (MOM-Br) in THF. It represents the first application of MOM-Br as a deoximation reagent to synthesize nitriles. The reaction was performed at reflux to ensure excellent yield (79-96%) of the nitriles within 20-45 minutes. Furthermore, this method has been successfully applied to the synthesis of the synthesis precursor of aromatic, heteroaromatic, cyclic, and acyclic aliphatic.

A novel series of tetrahydrothieno[2,3-c]pyridin-2-yl derivatives: fluorescence spectroscopy and BSA binding, ADMET properties, molecular docking, and DFT studies

“…In our previous studies, we synthesized compounds containing different substituents on different structures. 25–29 In this study, we present a different perspective via the theoretical study of the synthesis and molecular docking of compounds containing –NO 2 and -Cl ortho -, meta -, para -substituted phenyl. The primary objective of this work was to present novel approaches for the synthesis of compounds based on tetrahydrothieno[2,3- c ]pyridin-2-yl.…”

A simple and efficient method for constructing azocino[4,3-b]indole

“…Substituted nitriles are key molecular scaffolds in the synthesis of many organic compounds. [24][25][26][27] We now report an extension of this approach that leads to the synthesis of azocino [4,3b]indole. Furthermore, this kind of method has never been implemented in the synthesis of strychnos alkaloids.…”