A new rat model of diabetic macrovascular complication

Abstract

We have established a model of accelerated elastocalcinosis in diabetes related to its duration and localized in distal arteries. The modification of local protein expression is also in accordance with clinical data, suggesting that this model could be useful to investigate mechanisms related to this important clinical macrovascular complication of diabetes.

High Glucose Levels Increase Osteopontin Production and Pathologic Calcification in Rat Dental Pulp Tissues

“…In streptozotocin-induced diabetic rats, OPN plays a role in the development of diabetic vascular complications such as atherosclerosis, associated with the diabetic duration (34). The present results might also be associated with the duration of hyperglycemia, which might induce the hard tissue-forming potency of supplementary calcification with an increase of OPN in dental pulp.…”

Impaired Elastic Properties of the Aorta in Fat-Fed, Streptozotocin-Treated Rats

“…Subsequently, administration of low-dose STZ resulted in apparent hyperglycemia by slightly reducing the number of β cells [15]. This well-established model was characterized by impaired insulin sensitivity associated with insulin resistance [13, 16, 17], which replicated the natural history and metabolic characteristics of human type 2 diabetes [18]. …”

The impact of warfarin on the rate of progression of aortic stiffness in hemodialysis patients: a longitudinal study

“…Third, the temporal relationship between warfarin therapy and vascular calcification may not follow a linear pattern. Indeed, in non-CKD experimental model, high doses of warfarin are required for at least >3 weeks in order to induce vascular calcification, with a plateau effect after 4-8 weeks [15,36]. In addition, therapeutic warfarin in non-CKD rats (INR of between two and three) markedly depleted vitamin K levels within the vasculature, but it did not cause vascular calcification during the 7-week time frame of the study (unlike their CKD counterparts) [14,32].…”