A new rat model of neuropathic pain: Complete brachial plexus avulsion

Wang, Le; Liu, Yuzhou; Zhou, Yingjie; Lao, Jie; Zhao, Xin

doi:10.1016/j.neulet.2015.01.033

Cited by 31 publications

(31 citation statements)

References 15 publications

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“…42 In the behavioural assessment, MWT was used to detect mechanical allodynia, which has been frequently used in the sensation tests following brachial plexus nerve, median, and ulnar nerves, and sciatic nerve injuries in previous studies. [43][44][45][46] BPAI-induced pain in the injured forelimb subsequently caused central sensitisation and facilitation of pain sensation. 47 In the present sensory tests, the mechanical threshold of the intact forepaw was measured to quantitatively measure neuropathic pain following BPAI.…”

Section: Discussionmentioning

confidence: 99%

“…47 In the present sensory tests, the mechanical threshold of the intact forepaw was measured to quantitatively measure neuropathic pain following BPAI. 44 This was because the sensorimotor function of the affected limb completely lost after BPAI. Studies have demonstrated hypersensitisation in the intact limbs following BPAI and the pain threshold decreased.…”

Section: Discussionmentioning

confidence: 99%

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<p>Brain Metabolism in Rats with Neuropathic Pain Induced by Brachial Plexus Avulsion Injury and Treated via Electroacupuncture</p>

Huo

Zheng

Hua

et al. 2020

JPR

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These authors contributed equally to this workPurpose: Brain organisation is involved in the mechanism of neuropathic pain. Acupuncture is a common clinical practise in traditional Chinese medicine for the treatment of chronic pain. This study explored electroacupuncture's effects on brain metabolism following brachial plexus avulsion injury (BPAI)-induced pain. Methods: A total of 32 female rats were randomised into a normal group, model group, sham electroacupuncture group, and electroacupuncture group. A pain model was included via right BPAI. The electroacupuncture intervention at cervical "Jiaji" points (C5-7) was performed for 11 weeks. The mechanical withdrawal threshold of the non-injured (left) forepaw was measured at the baseline and on days 3, 7, 14, 21, 28, 56, 84, and 112 subsequent to BPAI. Positron emission tomography (PET) was applied to explore metabolic changes on days 28, 84, and 112. Results: After electroacupuncture, the mechanical withdrawal threshold of the left forepaws was significantly elevated and the effect persisted until 4 weeks after the intervention ceased (p<0.05 or p<0.001). In the sensorimotor-related brain regions, standardised uptake values in the bilateral somatosensory and motor cortices were observed in the electroacupuncture group. Metabolism particularly increased in the right somatosensory cortex. Metabolism changes also occurred in the pain-related brain regions and emotion-and cognition-related brain regions. Conclusion:The present study demonstrated the beneficial effects of electroacupuncture for relieving BPAI-induced neuropathic pain in rats. Electroacupuncture intervention might inhibit maladaptive plasticity in brain areas governing multidimensional functions, especially in sensorimotor-and cognition-related cortices.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

<p>Brain Metabolism in Rats with Neuropathic Pain Induced by Brachial Plexus Avulsion Injury and Treated via Electroacupuncture</p>

Huo

Zheng

Hua

et al. 2020

JPR

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“…Treatment of neuropathic pain remains a major challenge because it does not respond to most available medications [21]. Even opioids that are normally used as analgesics are commonly considered to have no effect on neuropathic pain [22]. Standard methods applied to treat neuropathic pain are normally used in managing BPA-induced pain, as evidencebased treatment methods specific to BPA are scarce [23].…”

Section: Discussionmentioning

confidence: 99%

Administration of Curcumin Alleviates Neuropathic Pain in a Rat Model of Brachial Plexus Avulsion

Xie¹,

Xie²,

Kang³

et al. 2019

Pharmacology

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Background/Aims: Brachial plexus avulsion (BPA) generally causes a chronic persistent pain that lacks efficacious treatment. Curcumin has been found to possess anti-inflammatory abilities. However, little is known about the mechanisms and effects of curcumin in an animal model of BPA. Methods: Mechanical withdrawal thresholds (MWT) were examined by von Frey filaments. Cold allodynia was tested by the acetone spray test. The levels of tumor necrosis factor-α (TNF-α) and interleukin (IL)-6 in rat spinal cords were analyzed by the enzyme-linked immunosorbent assay, and the expression levels of c-Fos and nerve growth factor (NGF) were measured by Western blot. The expression level of glial fibrillary acidic protein (GFAP) was observed by immunofluorescence and Western blot. Results: After curcumin treatment, the MWT showed a significant increase when compared to the BPA group on both hind paws. A remarkable decrease of paw-withdrawal response frequency was observed compared with the BPA group. In addition, curcumin treatment significantly decreased the levels of TNF-α and IL-6 in rat spinal cords that were exceedingly upregulated in the BPA group. The protein levels of c-Fos and NGF were decreased by treatment with curcumin compared with the corresponding protein levels in the BPA group. Besides, curcumin reduced the number of GFAP positive cells and GFAP expression. Conclusions: Our findings suggest that curcumin significantly extenuates the BPA-induced pain and inflammation by reducing the expression level of proinflammatory cytokines and pain-associated proteins and inhibiting the activity of astrocytes.

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Section: Fundamental Researchmentioning

confidence: 99%

“…These studies show that even remote motor injuries can have an effect on intact sensory systems that anatomically share a peripheral nerve or ganglia. In addition, following root avulsion, animals develop atlevel neuropathic pain at the adjacent dermatome Rodrigues-Filho et al, 2003;Bigbee et al, 2007;Chew et al, 2014;Wang et al, 2015) The ventral spinal nerve root and peripheral nerve Directly following axotomy, denervated Schwann cells in the ventral nerve roots and in the more distal peripheral nerves proliferate, align…”

Section: The Ventral Horn: Motoneuron Degeneration and Gliosismentioning

confidence: 99%

Clinical and neurobiological advances in promoting regeneration of the ventral root avulsion lesion

Eggers

Tannemaat

Winter

et al. 2015

Eur J of Neuroscience

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Root avulsions due to traction to the brachial plexus causes complete and permanent loss of function. Until fairly recent, such lesions were considered impossible to repair. Here we review clinical repair strategies and current progress in experimental ventral root avulsion lesions. The current gold standard in patients with a root avulsion is nerve transfer, whereas reimplantation of the avulsed root into the spinal cord has been performed in a limited number of cases. These neurosurgical repair strategies have significant benefit for the patient but functional recovery remains incomplete. Developing new ways to improve the functional outcome of neurosurgical repair is therefore essential. In the laboratory, the molecular and cellular changes following ventral root avulsion and the efficacy of intervention strategies have been studied at the level of spinal motoneurons, the ventral spinal root and peripheral nerve, and the skeletal muscle. We present an overview of cell-based pharmacological and neurotrophic factor treatment approaches that have been applied in combination with surgical reimplantation. These interventions all demonstrate neuroprotective effects on avulsed motoneurons, often accompanied with various degrees of axonal regeneration. However, effects on survival are usually transient and robust axon regeneration over long distances has as yet not been achieved. Key future areas of research include finding ways to further extend the post-lesion survival period of motoneurons, the identification of neuron-intrinsic factors which can promote persistent and long-distance axon regeneration, and finally prolonging the pro-regenerative state of Schwann cells in the distal nerve.

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A new rat model of neuropathic pain: Complete brachial plexus avulsion

Cited by 31 publications

References 15 publications

<p>Brain Metabolism in Rats with Neuropathic Pain Induced by Brachial Plexus Avulsion Injury and Treated via Electroacupuncture</p>

<p>Brain Metabolism in Rats with Neuropathic Pain Induced by Brachial Plexus Avulsion Injury and Treated via Electroacupuncture</p>

Administration of Curcumin Alleviates Neuropathic Pain in a Rat Model of Brachial Plexus Avulsion

Clinical and neurobiological advances in promoting regeneration of the ventral root avulsion lesion

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