A New Quassinoid from <i>Castela texana</i>

Dou, Jinhui; McChesney, James D.; Sindelar, Robert D.; Goins, D K; Walker, Larry

doi:10.1021/np960013j

Cited by 41 publications

(28 citation statements)

References 15 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For initial (primary) evaluation, extracts and fractions are screened at a single concentration (100 µg/mL). Follow-up secondary assays are conducted at three concentrations (10, 3.3, and 1.1 µg/mL), using a culture-treated 96-well microplate (Dou et al, 1996). The level of toxicity of each sample is determined by measuring the effect on a fibroblast cell line from African green monkey kidney (VERO; non-transformed).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and antioxidant activities of alkylated benzoquinones from Maesa lanceolata

Muhammad

Takamatsu

Walker

et al. 2003

Phytotherapy Research

Self Cite

View full text Add to dashboard Cite

The natural and semi-synthetic analogs of substituted 1,4-benzoquinones were evaluated for in vitro cytotoxic and antioxidant activities. Maesanin, dihydromaesanin, maesanin dimethyl ether and isomeric mixtures of 3-[(Z)-10'-pentadecenyl]-benzoquinone derivatives exhibited cytotoxic activity against HL-60 cell line (IC50 values 4.5, 2.2, 0.43 and 2.8 microg/mL, respectively), while it was found to be inactive against ROS (Reactive Oxygen Species) generation in HL-60. In contrast, the isomeric acylated benzoquinones with shorter alkyl substituents, namely, 2-acetoxy-5-hydoxy-6-methyl-3-tridecyl-1,4-benzoquinone and 2-hydoxy-5-acetoxy-6-methyl-3-tridecyl-1,4-benzoquinone showed most prominent antioxidant and antiproliferative effect on HL-60 (IC50 values 6.2 and 2.2 microg/mL, respectively), as well as cytotoxicities against SK-MEL, KB, BT-549 and SK-OV-3 carcinomas (IC50 values <1.1-4.2 microg/mL). All benzoquinones were found to be inactive against cell aggregation and cell adhesion assays, thus showing no effect on immune responses and inflammation.

show abstract

Section: Introductionmentioning

confidence: 99%

Cytotoxic and antioxidant activities of alkylated benzoquinones from Maesa lanceolata

Muhammad

Takamatsu

Walker

et al. 2003

Phytotherapy Research

Self Cite

View full text Add to dashboard Cite

show abstract

“…On the FBIT test, leaves also displayed interesting results (1.03 mg/ml), even more active than the bark extract (1.43 mg/ml). We did not find in the literature any activity reported for Castela coccinea, but another Castela species, Castela texana Rose from North-Eastern Mexico was evaluated, and antimalarial activity was reported for five quassinoids, with level of activity ranking from 0.01 to 0.92 g/ml (Dou et al, 1996). Of course, it is not the first time that antimalarial activity has been reported for Simaroubaceae species, as the very first biodiversity browsing for new antimalarial agents was initiated by Merck in South America in 1947, and already stressed out the pharmacological importance of Simaroubaceae together with Amaryllidaceae species.…”

Section: Castela Coccinea Griseb (Simaroubaceae)mentioning

confidence: 86%

A search for natural bioactive compounds in Bolivia through a multidisciplinary approach

Bourdy¹,

Oporto²,

Giménez³

et al. 2004

Journal of Ethnopharmacology

View full text Add to dashboard Cite

Seventy-seven plant extracts (corresponding to 62 different species) traditionally used by the Isoceño-Guaraní, a native community living in the Bolivian Chaco, were screened for antimalarial activity in vitro on Plasmodium falciparum chloroquine sensitive strain (F32), and on ferriprotoporphyrin (FP) IX biocrystallisation inhibition test (FBIT). Among these extracts, seven displayed strong in vitro antimalarial activity, and 25 were active in the FBIT test. Positive results on both tests were recorded for six extracts: Argemone subfusiformis aerial part, Aspidosperma quebracho-blanco bark, Castela coccinea leaves and bark, Solanum argentinum leaves and Vallesia glabra bark. Results are discussed in relation with Isoceño-Guaraní traditional medicine. Further studies to be undertaken in relation with these results are also highlighted.

show abstract

“…A primary assay for initial extracts/ fractions used a single concentration (100 mg/mL). In a secondary assay active extracts/pure compounds were tested at three concentrations (10, 3.3 and 1.1 mg/mL), using a culture-treated 96-well microplate (Dou et al, 1996). The level of general toxicity of each sample was also determined by measuring their effect on a fibroblast cell line from African green monkey kidney (VERO; non-transformed).…”

Section: Methodsmentioning

confidence: 99%

Cytotoxic sesquiterpene lactones from Centaurothamnus maximus and Vicoa pentanema

Muhammad¹,

Takamatsu²,

Mossa

et al. 2003

Phytotherapy Research

Self Cite

View full text Add to dashboard Cite

The aerial parts of Centaurothamnus maximus yielded three cytotoxic guaianolides, chlorojanerin (1), cynaropicrin (2) and janerin (3). The structure elucidation of 1-3 was based on (1)H and (13)C NMR data, mainly 2D-NMR (1)H-(1)H COSY and (1)H-(13)C HETCOR experiments. Compounds 1-3 showed in vitro cytotoxic activity against human cancer cell lines of malignant melanoma (SK-MEL), epidermoid (KB), ductal (BT-549) and ovarian (SK-OV-3) carcinomas with IC(50) values of 2-6 microgram/mL. In addition, 12 sesquiterpene lactones (4-15), isolated previously from the aerial parts of Vicoa pentanema, were evaluated for cytotoxic and antimicrobial activities. 2alpha- Acetoxy-3beta-hydroxyalantolactone (10) and 8beta-hydroxyparthenolide (14) were found to be the main cytotoxic agents (IC(50) values of 2-6 microgram/mL against SK-MEL, BT-549 and SK-OV-3), while lactones 4, 5, 11 and 15 selectively inhibited the growth of human malignant melanoma (IC(50) value of 3.6-7.3 microgram/mL). Cell aggregation and cell adhesion assays, using HL-60 and HeLa cell lines, evaluated the effect of cytotoxic constituents 1-3, 10 and 14 on immune response and inflammation.

show abstract

A New Quassinoid from Castela texana

Cited by 41 publications

References 15 publications

Cytotoxic and antioxidant activities of alkylated benzoquinones from Maesa lanceolata

Cytotoxic and antioxidant activities of alkylated benzoquinones from Maesa lanceolata

A search for natural bioactive compounds in Bolivia through a multidisciplinary approach

Cytotoxic sesquiterpene lactones from Centaurothamnus maximus and Vicoa pentanema

Contact Info

Product

Resources

About