A New Prognostic Index Combines the Metabolic Response and RECIST 1.1 to Evaluate the Therapeutic Response in Patients With Non-Small Cell Lung Cancer

Tang, Wen‐Fang; Hou, Qingyi; Lin, Jun‐Tao; Li, Dongjiang; Lin, Jingwei; Chen, Jinghua; Qiu, Zhicong; Chu, Xiang‐Peng; Yang, Xiongwen; Yan, Hong‐Hong; Wang, Shuxia; Wu, Yi‐Long; Zhong, Wen‐Zhao

doi:10.3389/fonc.2020.01503

Cited by 1 publication

(1 citation statement)

References 32 publications

(39 reference statements)

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“…At present, Response Evaluation Criteria in Solid Tumours (RECIST) is the gold standard for evaluating the efficacy of therapeutic interventions for lung cancer, with changes in tumour volume after treatment assessed by computed tomography (CT) or other radiographic methods to determine the curative effect. However, in contrast to cytotoxic chemotherapy, the mechanisms of action of targeted therapy and immunotherapy do not involve killing tumour cells directly, so the changes in tumour volume associated with these therapies usually occur later than the changes in functional indicators (4,5). It has been reported that the histopathological response of 41-45% of patients may be inconsistent with the results of CT evaluation (6).…”

Section: Introductionmentioning

confidence: 99%

Correlations between contrast-enhanced ultrasound and microvessel density in non-small cell lung cancer: A prospective study

Chen

Zhang²,

Tang³

et al. 2023

Front. Oncol.

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BackgroundImmunohistochemical microvessel density (MVD) is an early indicator of angiogenesis and it could be used to evaluate the therapeutic efficacy of non-small cell lung cancer (NSCLC). We sought to identify the ability of contrast-enhanced ultrasound (CEUS) in evaluating MVD of subpleural NSCLC.MethodsWe prospectively collected CEUS data of NSCLC confirmed by ultrasound-guided transthoracic needle biopsy from October 2019 to February 2021, The MVD of NSCLC counted by CD34-positive vessels of immunohistochemical staining. Microflow enhancement (MFE) of CEUS was divided into “dead wood”, “cotton”, and “vascular” patterns. Pathology subgroup and MVD between different MFE patterns were analyzed, respectively. The arrival time, time to peak, peak intensity (PI), and area under curve (AUC) derivefrom time-intensity curve of CEUS with MVD in NSCLC and its pathological subgroups (adenocarcinoma and squamous cell carcinoma) were subjected to correlation analysis.ResultsA total of 87 patients were included in this study, consisting of 53 cases of adenocarcinoma and 34 cases of squamous cell carcinoma with a mean MVD of 27.8 ± 12.2 mm–1. There was a significant statistical difference in MFE patterns between two pathological subgroups (p < 0.05). Besides, the MVD of “cotton” and “vascular” patterns were significantly higher than that of “dead wood” pattern (both of p < 0.05), whereas there was no significant difference in MVD between “cotton” pattern and “vascular” pattern. PI and AUC of CEUS were positively correlated with the MVD of NSCLC (r = 0.497, p < 0.001, and r = 0.367, p < 0.001, respectively). Besides, PI and AUC of CEUS were positively correlated with the MVD of squamous cell carcinoma (r = 0.802, and r = 0.663, respectively; both of p < 0.001). Only the PI was positively correlated with the MVD of lung adenocarcinoma (r = 0.288, p = 0.037).ConclusionsMFE patterns and quantitative parameters of CEUS had good correlation with MVD of NSCLC, especially in squamous cell carcinoma.

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Section: Introductionmentioning

confidence: 99%