A new procedure for fetal blood sampling in utero: Preliminary results of fifty-three cases

Daffos, F.; Capella-Pavlovsky, M; Forestier, F.

doi:10.1016/0002-9378(83)90982-1

Cited by 183 publications

(69 citation statements)

References 4 publications

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“…However, flow cytometry preparation and analysis requires more time, and is therefore not suited for (20 ). Amniotic fluid contamination is also a small risk in PUBS; in one series, contamination was reported in approximately 2.5% of umbilical blood samples (15/ 606) (7 ). Amniotic fluid has a lower pH (pH ϭ 7.1) and other important chemical differences (higher lactate) compared with healthy fetal blood (21 ).…”

Section: Confirmation Of Sample Integrity and Fetal Originmentioning

confidence: 99%

Fetal Laboratory Medicine: On the Frontier of Maternal–Fetal Medicine

Geaghan

2012

Clinical Chemistry

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BACKGROUND:Emerging antenatal interventions and care delivery to the fetus require diagnostic support, including laboratory technologies, appropriate methodologies, establishment of special algorithms, and interpretative guidelines for clinical decision-making.CONTENT: Fetal diagnostic and therapeutic interventions vary in invasiveness and are associated with a spectrum of risks and benefits. Fetal laboratory assessments are well served by miniaturized diagnostic methods for blood analysis. Expedited turnaround times are mandatory to support invasive interventions such as cordocentesis and intrauterine transfusions. Healthassociated reference intervals are required for fetal test interpretation. Fetal blood sampling by cordocentesis carries substantial risk and is therefore performed only when fetal health is impaired, or at risk. When the suspected pathology is not confirmed, however, normative fetal data can be collected. Strategies for assurance of sample integrity from cordocenteses and confirmation of fetal origin are described. After birth, definitive assessment of prenatal environmental and/or drug exposures to the fetus can be retrospectively assessed by analysis of meconium, hair, and other alternative matrices. A rapidly advancing technology for fetal assessment is the use of fetal laboratory diagnostic techniques that use cell-free fetal DNA collected from maternal plasma, and genetic analysis based on molecular counting techniques.

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Section: Confirmation Of Sample Integrity and Fetal Originmentioning

confidence: 99%

Fetal Laboratory Medicine: On the Frontier of Maternal–Fetal Medicine

Geaghan

2012

Clinical Chemistry

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show abstract

“…In 1973, Valente 31 described another interventional obstetric technique: blinded aspiration of the placenta to obtain fetal blood. Twenty years later, Daffos et al 32 described the technique of direct puncture of the umbilical cord with a 20-gauge needle for fetal blood sampling under sonographic control. This technique of percutaneous blood sampling has become routine practice in prenatal diagnosis.…”

Section: Fluid Aspiration/drainagementioning

confidence: 99%