A New Prenylated Indole Diketopiperazine Alkaloid from Eurotium cristatum

Zou, Xianwei; Li, Ying; Zhang, Xiaona; Li, Qian; Li, Xuan; Huang, Yun; Tang, Tao; Zheng, Shengping; Wang, Weimiao; Tang, Jintian

doi:10.3390/molecules191117839

Cited by 40 publications

(26 citation statements)

References 16 publications

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“…Cristatumins A–D ( 397 – 400 ) [ 156 ] and F ( 401 ) [ 166 ] were identified from the culture extract of Eurotium cristatum EN-220, an endophytic fungus isolated from the marine alga Sargassum thunbergii ( Figure 62 ). Cristatumin A ( 397 ) exhibited antibacterial activity against Escherichia coli (MIC—minimum inhibitory concentration—64.8 μg/mL), while cristatumin B ( 398 ) showed moderate activity against brine shrimp (LC 50 74.4 μg/mL) [ 156 ].…”

Section: Marine Indole Alkaloidsmentioning

confidence: 99%

“…Cristatumin F ( 401 ) exhibits a valine unit in its diketopiperazine structure, which is unprecedented. It also shows modest radical scavenging activity towards DPPH and a marginal cell proliferation inhibition [ 166 ]. Eurocristatine ( 402 ) was also isolated from E. cristatum and did not show any appreciable cytotoxic, antibacterial or antifungal activity [ 167 ].…”

Section: Marine Indole Alkaloidsmentioning

confidence: 99%

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Marine Indole Alkaloids

2015

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Marine indole alkaloids comprise a large and steadily growing group of secondary metabolites. Their diverse biological activities make many compounds of this class attractive starting points for pharmaceutical development. Several marine-derived indoles were found to possess cytotoxic, antineoplastic, antibacterial and antimicrobial activities, in addition to the action on human enzymes and receptors. The newly isolated indole alkaloids of marine origin since the last comprehensive review in 2003 are reported, and biological aspects will be discussed.

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Section: Marine Indole Alkaloidsmentioning

confidence: 99%

Section: Marine Indole Alkaloidsmentioning

confidence: 99%

Marine Indole Alkaloids

2015

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“…Unfortunately, there was no suitable combination of two or three amino acids among all 24 ones. We also considered the known compounds isolated from Eurotium cristatum (Du et al, 2014(Du et al, , 2017Du, Li, Li, Shang, & Wang, 2012;Gomes et al, 2012;Zou et al, 2014). However, there was no skeleton structures fit the above molecular formula.…”

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confidence: 99%

The hypoglycemic effect of extract/fractions from Fuzhuan Brick‐Tea in streptozotocin‐induced diabetic mice and their active components characterized by LC‐QTOF‐MS/MS

Xiang

Jin

et al. 2020

Journal of Food Science

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Fuzhuan Brick‐Tea is a postfermented product with the hypoglycemic effect, which is prepared from the leaves of Camellia sinensis var. sinensis. However, the material basis associated with the hypoglycemic effect was not clear. The present research was designed to explore the hypoglycemic effect of extract/fractions from Fuzhuan Brick‐Tea in streptozotocin‐induced type II diabetic mice. Then an ultra‐high pressure liquid chromatography along with quadrupole time of flight mass spectrometry was used to analyze the phytochemicals in Fuzhuan Brick‐Tea fractions. As a result, the hypoglycemic and hypolipidemic effects were evidently observed from the serum biochemical indexes and liver pathological examination in type II diabetic mice. In addition, there were total of 20 major components including eight lysophosphatidylcholines (Lyso‐PCs), five fatty acids, and seven novel theophylline derivatives tentatively identified in the active fraction from water extract. Therefore, these components were assumed to contribute partly to the hypoglycemic effect of Fuzhuan Brick‐Tea. These findings also give the evidence that the Lyso‐PCs, fatty acids, and novel theophylline derivatives in Fuzhuan Brick‐Tea may provide benefits in ameliorating disorders of glucose and lipid metabolism. Practical Application This study suggests that the Lyso‐PCs, fatty acids, and novel theophylline derivatives in Fuzhuan Brick‐Tea may provide benefits in ameliorating disorders of glucose and lipid metabolism. It can be taken as a beneficial diet additive or nutraceutical.

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“…The species within the genera Aspergillus , Eurotium , and Penicillium are main fungal taxa isolated from the postfermentation of dark tea (Mo et al, 2008). Aspergillus cristatus and Eurotium cristatum are golden flower fungi involved in the fermentation of Chinese fu‐zhuan tea (Ge et al, 2016; Zou et al, 2014). Numerous macroscopic yellow cleistothecia similar to that in other dark tea also could appear in pu‐erh tea after a long‐term storage, which was defined as JPT.…”

Section: Discussionmentioning

confidence: 99%

Correlation analysis between filamentous fungi and chemical compositions in a pu‐erh type tea after a long‐term storage

Zhou

Xiaoying

et al. 2020

Food Science & Nutrition

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Storage environment caused the difference between Jinhua Pu‐erh tea (JPT) and General Pu‐erh tea. In this study, fungal flora and chemical compositions were analyzed. The results showed that storage environment caused significant (p < .05) differences of theaflavins (TF), theabrownins (TB), tea polyphenols (TP), and water‐soluble sugars (WSS), and a highly significant (p < .01) difference of thearubigins (TR). Aspergillus niger, Aspergillus pallidofulvus, Aspergillus sesamicola, Penicillium manginii, and Aspergillus tamarii were isolated from Pu‐erh teas and identified based on colony characteristics and ITS, β‐tubulin, and calmodulin gene sequences, respectively. A. pallidofulvus, A. sesamicola, and P. manginii were dominant fungi in JPT and generated macroscopic yellow cleistothecia after a long‐term storage. Correlation analysis showed that dominant fungi exhibited significantly (p < .05 or p < .01) positive or negative corrections with TF, TB, TP, WSS, TR, and gallic acid. This study revealed dominant fungi including A. pallidofulvus, A. sesamicola, and P. manginii and their effects on given chemical compositions.

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A New Prenylated Indole Diketopiperazine Alkaloid from Eurotium cristatum

Cited by 40 publications

References 16 publications

Marine Indole Alkaloids

Marine Indole Alkaloids

The hypoglycemic effect of extract/fractions from Fuzhuan Brick‐Tea in streptozotocin‐induced diabetic mice and their active components characterized by LC‐QTOF‐MS/MS

Correlation analysis between filamentous fungi and chemical compositions in a pu‐erh type tea after a long‐term storage

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