A New Prenylated Flavonoid from Propolis Collected in Okinawa, Japan

Kumazawa, Shigenori; Goto, Hidenori; Hamasaka, Tomoko; Fukumoto, Syuichi; Fujimoto, Takunori; Nakayama, Tsutomu

doi:10.1271/bbb.68.260

Cited by 84 publications

(76 citation statements)

References 11 publications

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“…However, the Wolaita Soddo ATVET propolis extract has shown the median value of flavonoid content though it was found to have the lowest total phenolic content. In this study, Ethiopian propolis samples generally showed the highest total phenolic and total flavonoid contents compared to samples from Japanese [13] and propolis samples from Greek and Cyprus which ranged from 80.2 to 338 mg GAE/g EEP [35].…”

Section: Determination Of Total Flavonoids Inpropolis Extracts (Eep)mentioning

confidence: 57%

“…Like honey, propolis chemical variability is due to its plant origin and different geographic locations of the source plants [12]. Kumazawa et al [13] have reported that more than 300 compounds including different flavonoids, polyphenolic esters, terpenoids, steroids, amino acids, caffeic acids and their esters, and inorganic compounds have been identified in propolis samples. Phytochemical investigations of propolis have demonstrated the presence of flavonoids and polyphenolic components as the main active ingredients having potent antioxidant activities.…”

Section: Introductionmentioning

confidence: 99%

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Total phenols and antioxidant activities of natural honeys and propolis collected from different geographical regions of Ethiopia

Sime¹,

Atlabachew²,

Abshiro³

et al. 2015

Bull. Chem. Soc. Eth.

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ABSTRACT. In this study, ten honey and five propolis samples from different geographical origins were tested. Both honey and propolis samples showed high content of total phenolic compounds (330-610 mg gallic acid equivalent (GAE)/100 g honey; 365-1022 mg GAE/g ethanol extract of propolis (EEP). The total flavonoids ranged from (15.1-42.6 mg catechin equivalent (CE)/100 g for honey; to 123-74 mg CE/g for EEP. These honeybee products of Ethiopia had high total radical scavenging properties with respect to 2,2-diphenyl-1-picrylhydrazyl (DPPH); 18.1-59.8% and 48.6-87.8% for honey and EEP respectively. Furthermore, the hydroxymethylfurfural (HMF) of the honey samples was found to be low with a mean value of 4.8 mg/kg suggesting that the samples were of good quality. The antioxidant properties of the products showed a good correlation (r 2 = 0.50-0.82) with their polyphenolic contents.

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Section: Determination Of Total Flavonoids Inpropolis Extracts (Eep)mentioning

confidence: 57%

Section: Introductionmentioning

confidence: 99%

Total phenols and antioxidant activities of natural honeys and propolis collected from different geographical regions of Ethiopia

Sime¹,

Atlabachew²,

Abshiro³

et al. 2015

Bull. Chem. Soc. Eth.

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“…The presence of an isoprenyl group was indicated by 13 C NMR signals at δ 131.1 (C-3″), 124.6 (C-2″), 26.0 (C-5″), 23.3 (C-1″), and 17.9 ppm (C-4″). The three other methyl carbons resonated at δ 29.4 (C-12), 22.0 (C-13) and 16.5 ppm (C-11), and the methoxy carbon resonated at δ 56.5 ppm.…”

Section: Resultsmentioning

confidence: 99%

Antiproliferative Prenylated Stilbenes and Flavonoids from Macaranga alnifolia from the Madagascar Rainforest^,1

et al. 2007

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Bioassay-guided fractionation of an extract of the fruit of Macaranga alnifolia from Madagascar led to the isolation of four new prenylated stilbenes, schweinfurthins E-H (1-4), and one new geranylated dihydroflavonol, alnifoliol (5). The known prenylated stilbene, vedelianin (6), and the known geranylated flavonoids, bonanniol A (7), diplacol (8), bonannione A (9) and diplacone (10), were also isolated. All ten compounds were tested for antiproliferative activity in the A2780 human ovarian cancer cell line assay. Vedelianin (IC 50 = 0.13 µM) exhibited the greatest activity among all isolates, while schweinfurthin E (IC 50 = 0.26 µM) was the most potent of the new compounds.The genus Macaranga is a large genus of the Euphorbiaceae family. Observation of Macaranga plants in their natural environment has revealed that they produce thread-like wax crystals on their ste ms, which make the slippery surfaces impassable for all insects except a species of ants known as "wax runners". Chemical analysis has indicated that terpenoids make up a majority of the wax bloom content that helps maintain this symbiotic relationship between plant and insect. 2 One of the more commonly studied species of this genus is M. tanarius, noted for its diterpenoid 3,4 and flavonoid 5-7 content. Work has also been performed on the isolation and characterization of terpenes from M. carolinensis ,8 flavonoids from M. conifera 9 and M. denticulate ,10 chromenoflavones from M. indica , 11 clerodane diterpenes from M. monandra , 12 bergenin derivatives and polyphenols from M. peltata , 13 , 14 prenylflavones from M. pleiostemona , 15 a geranyl flavanone from M. schweinfurthii ,16 tannins from M. sinensis ,17 a rotenoid and other compounds from M. triloba , 18 and a geranylflavonol from M. vedeliana. 19 No phytochemical studies have been previously reported for M. alnifolia.

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“…However, in the present study, even larger amounts of phenolic compounds were found (745.69 mg/g). Brazilian propolis samples analyzed in this study also contained more total phenolic content than samples from other countries, such as China (302 ± 4.3 mg/g, Ahn et al, 2007, and 299 ± 0.5 mg/g, Kumazawa et al, 2004), Korea (212.7 ± 7.4 mg/g, Choi et al, 2006), Argentina (187 mg/g, Bankova et al, 2000), India (159.10 ± 0.26 mg/g, Laskar et al, 2010), Portugal (151 ± 0.01 mg/g, Moreira et al, 2008) andThailand (31.2 ± 0.7, Kumazawa et al, 2004).…”

Section: Discussionmentioning

confidence: 62%

“…It is used as a sealant for unwanted open spaces in the hive and contains mostly sticky plant substances, beeswax and other bee secretions (Lotti et al, 2010). Numerous biological properties have been attributed to propolis, including antimicrobial, anti-inflammatory (Park et al, 2002), anticarcinogenic, antioxidant (Burdock, 1998;Kumazawa et al, 2004) antitumoural and immunomodulatory (Frozza et al, 2013), and wound healing activities (Albuquerque Junior et al, 2009). However, its chemical composition and pharmacological activity vary widely from region to region (Piccinelli et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

Chemical markers and antifungal activity of red propolis from Sergipe, Brazil

Mendonça

Araujo

et al. 2015

Food Sci. Technol (Campinas)

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The aim of this study was to analyze the physicochemical properties and antifungal activities of the red propolis samples from Sergipe, Brazil, and also evaluate their variability throughout the year. The characterization of the hydroalcoholic extract (HPE) of the red propolis samples was performed monthly from Dctober 2009 to September 2010. The concentrations of the bioactive compounds varied during the year, but their chromatographic profiles were similar. Four compounds were identified by comparison with authentic standards. Formononetin was one of the predominant compounds in all propolis extracts. In our study, it was observed that all the propolis samples inhibited the growth of Candida species. Multivariate analysis confirmed the variations in chemical composition and color of the HPEs throughout the year. The biological activities of the HPEs were statistically significant (p<0.05), and all samples exhibited antifungal properties.

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A New Prenylated Flavonoid from Propolis Collected in Okinawa, Japan

Cited by 84 publications

References 11 publications

Total phenols and antioxidant activities of natural honeys and propolis collected from different geographical regions of Ethiopia

Total phenols and antioxidant activities of natural honeys and propolis collected from different geographical regions of Ethiopia

Antiproliferative Prenylated Stilbenes and Flavonoids from Macaranga alnifolia from the Madagascar Rainforest^,1

Chemical markers and antifungal activity of red propolis from Sergipe, Brazil

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A New Prenylated Flavonoid from Propolis Collected in Okinawa, Japan

Cited by 84 publications

References 11 publications

Total phenols and antioxidant activities of natural honeys and propolis collected from different geographical regions of Ethiopia

Total phenols and antioxidant activities of natural honeys and propolis collected from different geographical regions of Ethiopia

Antiproliferative Prenylated Stilbenes and Flavonoids from Macaranga alnifolia from the Madagascar Rainforest,1

Chemical markers and antifungal activity of red propolis from Sergipe, Brazil

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Antiproliferative Prenylated Stilbenes and Flavonoids from Macaranga alnifolia from the Madagascar Rainforest^,1