A New Predictor for Obstructive Sleep Apnea Syndrome: Monocyte to HDL Ratio

Atan, Doğan; Kundi, Fatma Cemre Sazak; Özcan, Kürşat Murat; Dere, Hüseyin

doi:10.1007/s12070-016-0980-6

Cited by 17 publications

(17 citation statements)

References 21 publications

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“…In our study, significantly higher MHR values were observed in patients with OSA when compared with the control group. The MHR values had a linear correlation with AHI, and the severity of hypoxemia defined by mean SpO 2 , LSpO 2 and TS90, which was consistent with previous studies (17,19). Furthermore, the levels of MHR were significantly higher in OSA patients with CVD, especially in severe OSA group.…”

Section: Discussionsupporting

confidence: 90%

“…Recent study found significant increase of total monocyte in bone marrow and peripheral blood upon OSA related chronic intermittent hypoxia (CIH) exposure (15), and OSA severity was independently associated with low HDL-C values as well (16). Atan et al (17) reported MHR increased as OSA severity increased, which can be used as a new predictor for OSA. However, the association between MHR and CVD occurrence in patients with OSA still lacks clinical evidence and has not been well understood, especially in Chinese Han population.…”

Section: Original Articlementioning

confidence: 99%

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Relationship between monocyte to HDL cholesterol ratio and concomitant cardiovascular disease in Chinese Han patients with obstructive sleep apnea

Ren

Wang

et al. 2019

Cardiovasc. Diagn. Ther.

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Background: Obstructive sleep apnea (OSA) is an independent risk factor for cardiovascular disease (CVD), which is attributed to chronic intermittent hypoxia (CIH) induced inflammation. As a new inflammatory biomarker of CVD, monocyte to high-density lipoprotein cholesterol ratio (MHR) has received little attention in OSA studies to date. Therefore, we aimed to investigate the correlation between MHR and concomitant CVD in Chinese Han patients with OSA. Methods: A total of 657 Chinese Han subjects (169 controls, 145 mild, 94 moderate, and 249 severe OSA) of both genders were enrolled in this cross-sectional study, with an average BMI of 32.35±6.56 kg/m 2. The relationship between MHR and concomitant CVD in OSA patients was analyzed. Results: The level of MHR was correlated positively with apnea-hypopnea index (AHI), while negatively with lowest SpO 2 (P<0.01). Moreover, the MHR values were higher in OSA patients with CVD than those without CVD (17.64±7.16 vs. 12.73±5.06, P<0.001). Logistic regression analysis demonstrated that MHR is an independent predictor of CVD (OR =1.190, P<0.001). The ROC analysis indicated that the best cutoff value of MHR for predicting CVD in OSA patients was 15.364 (sensitivity 65.0%, specificity 74.4%), while its cutoff value for identifying CVD in severe OSA patients was 15.362 (sensitivity 67.3%, specificity 80.1%). Conclusions: MHR is strongly correlated with the severity of OSA and the occurrence of CVD in OSA patients. As an easy and available test, MHR is expected to be a promising biomarker candidate in predicting CVD in Chinese Han patients with OSA.

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Section: Discussionsupporting

confidence: 90%

Section: Original Articlementioning

confidence: 99%

Relationship between monocyte to HDL cholesterol ratio and concomitant cardiovascular disease in Chinese Han patients with obstructive sleep apnea

Ren

Wang

et al. 2019

Cardiovasc. Diagn. Ther.

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“…As MHR is an inexpensive and readily available parameter, it has become more widely used in recent years, and has been related to several clinical conditions (13)(14)(15)(16). The relationship between OSAS and MHR was first investigated by Atan et al in 2007, and it was determined that MHR could be a predictive marker in OSAS diagnosis (17). In the present study, the value of MHR of the patients with OSAS was determined to be statistically significantly higher than that of the control group.…”

Section: Discussionmentioning

confidence: 99%

The Monocyte/HDL Cholesterol Ratio in Obstructive Sleep Apnea Syndrome

Acat¹,

Yazici²

2018

meandros

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Objective: Obstructive sleep apnea syndrome (OSAS) is the most common condition among sleep-related respiratory disorders. The etiology is not clear. However, systemical and local inflammation in the respiratory tract of the patients has been acknowledged. Monocytes and macrophages play the critical role in the inflammation process. These cells participate in the release of the proinflammatory cytokines in inflammation sites. High-density lipoprotein (HDL) cholesterol is a molecule with an anti-inflammatory effect. Monocyte/HDL cholesterol ratio (MHR) is an inflammation marker being used recently. In our study, we aimed to compare inflammation marker levels between patients diagnosed with OSAS with subsequent polysomnography and the non OSAS group, determine the relationship between the severity of OSAS and MHR and, investigate the utility of the MHR for diagnosing OSAS. Materials and Methods: The data from the patients' files who had polysomnography due to OSAS symptoms in our unit between July 2017 and December 2017 have been retrospectively analyzed, and polysomnography results were recorded. Demographic data and the results of biochemistry and complete blood count (CBC) panels of patients with OSAS and who were not also were recorded. Results: Out of 147 patients who underwent polysomnography in the period identified, 104 were diagnosed with OSAS. Monocyte count and MHR values were significantly high (p<0,0001 in both) and HDL levels were significantly low (p=0,03) in OSAS group. There was also a moderately significant positive correlation between apnea-hypopnea index (AHI) and MHR (p<0,0001, r: 0,411). Conclusion: MHR may be a useful tool for diagnosing OSAS. Because of the positive correlation between MHR and AHI which represents the severity of the disease, MHR may be used for the classification of OSAS. Öz Amaç: Obstrüktif uyku apne sendromu (OSAS) uyku ile ilişkili solunum bozuklukları içerisinde en sık görülen hastalıktır. OSAS'ın etyolojisi kesin olarak bilinmemekle birlikte hastalarda sistemik ve havayolunda lokal inflamasyon varlığı gösterilmiştir. Monosit ve makrofajlar inflamasyonda rol alan önemli hücrelerdir. İnflamasyon bölgesinde proinflamatuar sitokinlerin salınmasında görev alırlar. Yüksek dansiteli lipoprotein (HDL) kolesterolü anti inflamatuar etkisi olan bir moleküldür. Monosit/HDL kolesterol oranı (MHO) yakın zamanda kullanılmaya başlanan bir inflamasyon belirtecidir. Çalışmamızda ünitemizde polisomnografi ile OSAS tanısı alanların ve almayanların Ad dress for Cor res pon den ce/Ya zış ma Ad re si:

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“…is > 5 or the AHI is > 15 for an asymptomatic patient [1,2]. Recurrent nocturnal apnea episodes in OSAS patients cause sympathetic system activation, increased oxidative stress, endothelial dysfunction, sudden increase in systemic hypertension, hypoxia and hypercapnia [3].…”

mentioning

confidence: 99%

“…There was a positive correlation between MHR and the severity of hypoxemia defined by oxygen desaturation index (ODI) [47]. MHR, AHI, rapid eye movement (REM) -AHI, non-REM-AHI and oxygen saturation have been shown to increase significantly as time increases below 90% and the minimum oxygen concentration decreases [2] independently associated with corner atherosclerosis assessed by SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) score in patients with independent coronary artery disease. In addition, a positive correlation was found between CRP and MHR [48].…”

mentioning

confidence: 99%

Cardiovascular Dısease Risk in Patients with Obstructıve Sleep Apnea Syndrome

Ölmez

Işık

2019

Galician med. j.

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Obstructıve sleep apnea syndrome is a clinical syndrome characterized by recurrent partial or total obstruction of the upper respiratory tract. The main symptoms are snoring, excessive daytime sleepiness and witnessed apnea. It is a disease that affects 3% to 7% of the middle-aged population. Studies and meta-analyzes have shown that cardiovascular diseases are more common in patients with obstructıve sleep apnea syndrome. Comorbid conditions such as obesity, metabolic syndrome and smoking are higher in obstructıve sleep apnea syndrome patients than in the general population. In addition, hypoxia-reperfusion injury due to intermittent oxygen desaturation occurring in obstructıve sleep apnea syndrome patients, endothelial dysfunction, increased sympathetic system activity, platelet activation, monocyte increase, which play the main role in arteriosclerosis, decreased and increased low-density lipoprotein cholesterol may also be the reason for the frequent occurrence of cardiovascular diseases. The development of cardiovascular disease in obstructıve sleep apnea syndrome patients is an important cause of morbidity and mortality. Evaluating white blood cell neutrophil/lymphocyte ratio, platelet/lymphocyte ratio, lymphocyte/monocyte ratio, hematocrit, platelet distribution width, red cell distribution width, C-reactive protein, and monocyte/high-density lipoprotein cholesterol ratio in the follow-up of obstructıve sleep apnea syndrome patients may be helpful in predicting the development of cardiovascular diseases. Whether obstructıve sleep apnea syndrome patients have metabolic syndrome or smoking should be questioned. Obstructıve sleep apnea syndrome, obesity, smoking and depression are increasingly prevalent diseases worldwide, leading to significant mortality and morbidity. Therefore, multicentre studies involving different societies are needed.

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A New Predictor for Obstructive Sleep Apnea Syndrome: Monocyte to HDL Ratio

Cited by 17 publications

References 21 publications

Relationship between monocyte to HDL cholesterol ratio and concomitant cardiovascular disease in Chinese Han patients with obstructive sleep apnea

Relationship between monocyte to HDL cholesterol ratio and concomitant cardiovascular disease in Chinese Han patients with obstructive sleep apnea

The Monocyte/HDL Cholesterol Ratio in Obstructive Sleep Apnea Syndrome

Cardiovascular Dısease Risk in Patients with Obstructıve Sleep Apnea Syndrome

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