A New Potent Anti-cancer Corosolic Ester Identified from the Super Miracle Plant Hippophae rhamnoides (Sea buckthorn)

Ali, Irfan; Zahra, Noor-ul-Ain; Reazuddin, R; Sharif, Huma; Mudassar, M; Bhatti, Huma Aslam

doi:10.33805/2638-7735.119

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…In recent years, research has shown that sea buckthorn can help with illness prevention and healing, including viral infections and cancer (15,28) owing to its antioxidant (29,30), anti-inflammatory (31), antiviral (32), antimicrobial (24, 30, 33), and antibacterial (34, 3 5 ) p r o p e r t i e s . C a r d i o p r o t e c t i v e , a n t i -a t h e r o g e n i c , hepatoprotective, hypolipidemic (29,36,37), dermatological (4), antiproliferative (20), and anticancer (e.g., colon, liver, lung, cervical, ovarian, and breast cancer cells) effects have been reported, too (6,15,38). Proanthocyanidins, curcumin, and resveratrol have been demonstrated to have considerable advantages in cancer chemoprevention and radiotherapy (39).…”

Section: Physiological and Therapeutic Actionsmentioning

confidence: 99%

Sea buckthorn, its bioactive constituents, and mechanism of action: potential application in female reproduction

Mihal,

Roychoudhury,

Sirotkin

et al. 2023

Front. Endocrinol.

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Sea buckthorn (Hippophae rhamnoides L.) is a flowering shrub, and its berries have been utilized for decades as a raw ingredient in cuisines and herbal remedies. This evidence-based study focuses on its key bioactive constituents, and mechanism of protective effects with a focus on female reproductive processes. Parts of the plant contain phenols, carotenoids (lycopene, carotene, lutein, and zeaxanthin), flavonoids (isorhamnetin, quercetin, glycosides, and kaempferol), tocopherols, sterols, polyunsaturated fatty acids, minerals, vitamins, omega 3, 6, 9 and rare omega 7 fatty acids etc. Key polyphenolic flavonoids such as isorhamnetin and quercetin are believed to be mainly responsible behind its health benefits (against cardiovascular diseases, metabolic syndrome, obesity etc.) through properties including anti-cancer, antioxidant, and anti-inflammatory activities. These sea buckthorn constituents appear to mediate healthy ovarian cell proliferation, death, and hormone release, as well as decrease ovarian cancer possibly through apoptosis, and hormonal (estrogen) release. Thus, sea buckthorn and its bioactive ingredients may have potential in the management of gynecological problems such as uterine inflammation, endometriosis, and easing symptoms of vulvovaginal atrophy in postmenopausal women (by targeting inflammatory cytokines and vascular endothelial growth factor – VEGF). Apigenin, myricetin, and luteolin have also been recommended as prospective ovarian cancer preventative and adjuvant therapy options as they can inhibit ovarian cancerogenesis by triggering apoptosis and halting the cell cycle in ovarian tumors. Furthermore, its oil (containing carotenoid, sterol, and hypericin) has been speculated as an alternative to estrogen replacement therapy for postmenopausal women particularly to improve vaginal epithelial integrity. However, it is uncertain whether steroid hormone receptors, reactive oxygen species (ROS), and inflammatory regulators are actually behind sea buckhorn’s actions. Sea buckthorn, and its compounds’ health promoting potential warrants further validation not just in vitro and in animal research, but also in clinical trials to identify and/or standardize optimal methods of delivery of biologically active molecules.

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Section: Physiological and Therapeutic Actionsmentioning

confidence: 99%

Sea buckthorn, its bioactive constituents, and mechanism of action: potential application in female reproduction

Mihal,

Roychoudhury,

Sirotkin

et al. 2023

Front. Endocrinol.

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A supernatural multipurpose plant Sea buckthorn (Hippophae rhamnoides L.): An updated overview of its folk traditional uses, phytochemical profile and biological activities

Hussain

Abidi

Syed

et al. 2023

JBR

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BACKGROUND: Sea buckthorn (SBT) (Hippophae rhamnoides L.), a shrub rich with a huge variety of vitamins, antioxidants and other biologically active constituents with pharmacological and cosmaceutical applications. OBJECTIVE: The current review aims to compile the recent reported data on the ethnobotany, phytochemistry, biological activities and cosmaceutical uses of SBT plant from different regions of the world. METHODS: A wide-ranging inquiry on SBT was done electronically on the basis of articles and abstracts published in peer-reviewed journals, issued in conference proceedings, government reports, books, Master’s and Ph.D. theses etc. The research was carried out in different International scientific databases like Academic Search, Biological Abstracts, BIOSIS, BioOne Previews, CabDirect, Cochrane Library, Pubmed/Medline, GeoRef, Google Scholar, JSTOR, Journal Citation Reports, Mendeley, Publons, Researchgate, Scopus, SciELO, Springer Link, Science Direct, Web of Science, Taylor and Francis with particular keywords. RESULTS: A total of 185 published papers were assessed through the search approach and 162 papers were included published on SBT. It was evident from the literature search that the uses of SBT as traditional medicine so far against nearly 50 health related complications in more than 18 regions of the world are still a common practice where the decoction of leaves and juice/paste from berries/fruits of SBT were the common administration modes. Data on the phytochemical profile of SBT revealed more than 50 diverse reported groups of compounds with remarkable antioxidant activity against reactive oxygen species (ROS) using DPPH, FRAP and ABTS as common methods. Moreover to-date, the reported antimicrobial activity of SBT uncovered that the extracts from SBT were examined in contradiction of 32 strains of bacteria and 15 strains of fungus with significant inhibitory actions against the bacterial and fungal strains. The SBT extracts actions reported so far on different viral disease categories displayed active inhibition of the growth of nearly 15 different viral strains. The reported anticancer activity of compounds in SBT extracts to date evidenced remarkable results against more than 20 different cancer cell lines/ types. Moreover, SBT oil containing fatty acids, tocopherols and carotenoids is effectively used with cosmetics applications for skin care. CONCLUSIONS: Conclusively, SBT is rich with several remarkable phytochemicals that may have diverse biological actions and for that reason reassure the use of decoctions and/or infusions of SBT as folk traditional medicine around the world. Conversely, it is essential to explore the molecular mechanisms of compounds responsible for biological activites of SBT and to advance in the research of clinical uses and development of SBT based therapeutic and cosmetic products.

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A New Potent Anti-cancer Corosolic Ester Identified from the Super Miracle Plant Hippophae rhamnoides (Sea buckthorn)

Cited by 2 publications

References 28 publications

Sea buckthorn, its bioactive constituents, and mechanism of action: potential application in female reproduction

Sea buckthorn, its bioactive constituents, and mechanism of action: potential application in female reproduction

A supernatural multipurpose plant Sea buckthorn (Hippophae rhamnoides L.): An updated overview of its folk traditional uses, phytochemical profile and biological activities

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