A New Polymorph of 1-Acetyl-2-thiohydantoin

1-Acetyl-5-(4-fluorophenyl)-2-sulfanylideneimidazolidin-4-one

“…For applications and the biological activity of 2-sulfanylideneimidazolidin-4-ones, see: Marton et al (1993). For the crystal structures of related compounds, see: Casas et al (1998); Sulbaran et al (2007); Taniguchi et al (2009). For a description of the Cambridge Structural Database, see: Allen (2002).…”

“…The Cambridge Structural Database survey (Ver. 5.34; Allen, 2002) indicates that 1-acetyl-2-thiohydantoins with an unsubstituted N atom show three types of N-H•••O hydrogen-bonding patterns: (i) the amide NH and the acetyl C═O groups form a chain with a C(6) graph-set motif (Etter et al, 1990) [triclinic polymorph of 1-acetyl-2-thiohydantoin (NIFHIT01) (Taniguchi et al, 2009) and two other derivatives (KABRIQ and KOMGUO)]; (ii) the amide NH and the amide C═ O groups form a chain with C(4) [monoclinic polymorph of 1-acetyl-2-thiohydantoin (NIFHIT) (Casas et al, 1998) and one other derivative (DOKXUX)]; (iii) the amide NH and the amide C═O groups form a ring with R 2 2 (8) [1-acetyl-5-methyl-2-thiohydantoin (DIKWAW) (Sulbaran et al, 2007)]. As an extension of our research, we report on the crystal structure of the title compound, C 11 H 9 FN 2 O 2 S.…”

A novel triphenylamine based push–pull fluorophore bearing a 2-thiohydantoin unit for toxic Hg2+ ion detection: exploring its potential for live cell imaging

“…This structural feature allows for the formation of diverse hydrogen bonding networks in its crystal structure. 45,46 As a result of our interest in designing and developing a new fluorescence sensor, we have developed a TPA and 2TH based chemosensor (TPA-2TH) with TPA as a donor and the 2TH unit acting as an Hg 2+ ion chelator and acceptor. In this report, we aim to develop a novel TPA-2TH molecular probe through Knovenagel condensation between TPA aldehyde and 2TH.…”

Crystal structures of racemic and enantiomeric 5-isopropyl-5-methylhydantoin

“…This unique structural feature endows the compounds with unique physicochemical and biological properties [14,15]. We have studied the crystal structures of a series of hydantoins and 2-thiohydantoins in order to get information on the factors controlling the molecular environment in the crystal [16][17][18][19][20][21][22].…”