A New Pimarane Diterpenoid from the Botryotinia fuckeliana Fungus Isolated from Deep‐Sea Water

Abstract

A new pimarane diterpenoid, named botryopimarene A (1), was discovered from the fungus Botryotinia fuckeliana MCCC 3 A00494 isolated from the deep-sea water, together with ten known compounds. The planar structure of 1 was established based on the extensive spectroscopic analyses. The absolute configurations of tricyclic system in 1 were resolved by the theoretical ECD calculation, while the 15,16-diol moiety in the side chain was resolved by the Mo 2 (OAc) 4 -induced ECD spectrum. Compound 1, featuring a Δ 9(11) double bond, was rarely discovered in pimarane family. Compounds 1-11 were tested for their cytotoxic activities using six human cancer cell lines by the MTT method. However, none of the compounds exhibited detectable cytotoxicities (IC 50 > 20 μM).

Deep-Sea-Derived Fungi as Valuable Producers of Cytotoxic Secondary Metabolites and Their Leads Potential

“…Compounds 70−74 exhibit cytotoxic activities against the A549, HEK293, MCF-7, SMMC-7721, and T-47D cell lines, with IC 50 values of 10−48 mM. A new pimarane-type diterpenoid, botryopimarene A (75), was discovered from the deep-sea fungus B. fuckeliana MCCC 3A00494 (Niu et al, 2019b). Photeroids A (76) and B (77), two unique phenol-sesquiterpene meroterpenoids, were isolated from Phomopsis tersa FS441, a fungus separated from a sediment sample that was collected at a depth of 3000 m in the Indian Ocean (88°58.640′ E, 0°00.307′ S) (Chen et al, 2020a).…”

Anti-Food Allergic Compounds from Penicillium griseofulvum MCCC 3A00225, a Deep-Sea-Derived Fungus

“…Then the ICD spectra were measured every 3 min until they were stationary. The inherent CD data of compound 8 was subtracted to provide its induced CD spectrum as described previously [41,42].…”

Two New Phenol Derivatives from the Cold Seep‐Derived Fungus Aspergillus insuetus SD‐512

“…Deep‐sea has been proved to be a great treasure for structural unique and biological active natural products in last two decades [1–3] . Cold seeps are the typical deep‐sea chemosynthetically‐driven ecosystems, characterized as methane‐rich fluid emissions and distinctive sulfur oxidation‐reduction reactions, which led to high abundance of specialized cold seep microorganism [4,5] .…”