A New Phenylethanoid Glycoside From the Leaves of Rosmarinus officinalis With Nitric Oxide Inhibitory Activity

Abstract

A new phenylethanoid glycoside, named rosmacinalis (1), and 6x known compounds {2-phenylethyl O-α-L-rhamnopyranosyl-(1‴→6″)- O-β-D-glucopyranoside (2), clinopodiolide C (3), rosmanol (4), 7 α-methoxyrosmanol (5) 7 β-methoxyrosmanol (6) and carnosol (7)} were isolated from the leaves of Rosmarinus officinalis. Their structures were determined by extensive analysis of high-resolution electron spray ionization mass spectrum and nuclear magnetic resonance spectral data, as well as by comparison of the spectral data with those reported in the literature. Anti-inflammatory activity of compounds 1‐7 was evaluated by their inhibition of NO production in lipopolysaccharide-stimulated RAW 264.7 cells. At a concentration of 100 µM, compounds 1 and 2 exhibited inhibitory rates of 47.1% ± 2.2% and 44.5% ± 1.3%, respectively, while compounds 3‐7 showed a cytotoxic effect. After dilution to a concentration of 20 µM, except compound 7, compounds 1‐6 did not show a cytotoxic effect. Their NO inhibitory rates ranged from 14.2% ± 1.3% to 31.1% ± 1.9%.

New Truxinic and Truxillic Acid Sucrose Diesters From the Leaves of Trigonostemon honbaensis

“…Compounds 1 and 2 were evaluated for their anti-inflammatory activity by inhibition of NO production in LPS-stimulated RAW264.7 macrophages, as previously described. 15 At a concentration of 20 µM, compounds 1 and 2 weakly inhibited NO production (inhibitory percentages of 22.7% ± 1.1% and 18.5% ± 1.4%, respectively) in comparison with the positive control L-NMMA (N G -monomethyl-L-arginine, inhibitory percentage of 82.6% ± 1.9%).…”

Diterpenoids from Rosmarinus officinalis L. and their nitric oxide inhibitory activity

“…Inhibition of NO production in LPS-stimulated RAW 264.7 cell assay, see reference [14]. .6 together with a singlet aromatic proton signal at δ H 6.56 were assigned to a pentasubtituted aromatic ring.…”

A new lignanamide from the stems of Derris elliptica (Wall.) Benth with antimicrobial and anti‐inflammatory activities

“…Flavonoids, coumaronochromone derivatives rotenoids, Ncontaining rotenoids, and pyrrolidine derivatives were isolated and exhibited potential anti-cancer, antiinflammation, and antimicrobial activity. [4][5][6][7][8][9] With the aim to clarify the bioactive constituents of D. elliptica, herein, we describe the isolation and structural elucidation of a new lignanamide (1) and ten known compounds (2)(3)(4)(5)(6)(7)(8)(9)(10)(11) from the stems of D. elliptica (figure 1). The isolated compounds were investigated antimicrobial activity on typical Gram (+) bacteria (Enterococcus faecalis, Staphylococcus aureus, and Bacillus cereus), Gram (-) bacteria (Escherichia coli, Pseudomonas aeruginosa, and Salmonella enterica) and yeast Candida albicans.…”