A New Phenomenon of Local Skin Reactivity to B. Typhosus Culture Filtrate.

Shwartzman, Gregory

doi:10.3181/00379727-25-3950

Cited by 101 publications

(51 citation statements)

References 3 publications

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“…Local application of small amounts of LPS can sensitize the vascular endothelium and a subsequent LPS challenge can produce vascular lesions with fluid exudation (10). This phenomenon, the local Shwartzman reaction, was initially reported in the rabbit skin (22), but recent reports indicate that the vasculature ofthe kidney is also susceptible to such reactions (23). Studies on the mechanism of pathogenesis of the Shigella group of organisms during the first decade of this century showed that the infusion of filtered broths or heat-killed cultures of Shigella produced, in addition to a neurotoxic syndrome, hemorrhagic enteritis in a variety of experimental animals (24)(25)(26)(27)(28).…”

Section: Discussionmentioning

confidence: 99%

Bacterial lipopolysaccharide-induced intestinal microvascular lesions leading to acute diarrhea.

Mathan

Penny²,

Mathan³

et al. 1988

J. Clin. Invest.

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Subcutaneous challenge of mice with lipopolysaccharide (LPS) from gram negative bacteria, produced an intestinal microvascular lesion causing fluid exudation into the lumen of the intestine and diarrhea. The microvascular lesion was characterized by endothelial cell damage and microthrombi in the venules and capillaries of the intestinal lamina propria. Marker organisms, given orally to challenged mice, grew in the exuded fluid and could invade the mucosa. Intravenous transfer of postchallenge plasma produced the lesion in normal mice and absorption of such plasma by Sepharose coupled to LPS-antibody abolished this effect. Instillation of large quantities of LPS into the lumen of the intestine produced scattered microvascular lesions, although none of these animals developed diarrhea. Since a similar microvascular lesion has been described in the rectal mucosal lamina propria of adults with acute diarrhea, it is suggested that LPS-induced vascular damage may be a novel mechanism in the pathogenesis of acute diarrhea.

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Section: Discussionmentioning

confidence: 99%

Bacterial lipopolysaccharide-induced intestinal microvascular lesions leading to acute diarrhea.

Mathan

Penny²,

Mathan³

et al. 1988

J. Clin. Invest.

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show abstract

“…However, an alternative model of pregnancy was also postulated, leading to the MedawarShwartzman paradox. The localized Shwartzman reaction of hemorrhagic necrosis is induced in some animals by a priming injection of endotoxin followed by a sublethal intravenous endotoxin injection 24 h later [13]. Identical pathological lesions are observed in pregnant animals after just a single intravenous injection of endotoxin, without requiring a priming injection [14].…”

Section: What Is the Immunology Of Pregnancy?mentioning

confidence: 99%

Recurrent miscarriages: What is the role of cytokines?

Calleja‐Agius

Brincat

2008

Gynecological Endocrinology

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Recurrent miscarriage is defined as three or more consecutive miscarriages before 20 weeks of gestation. This condition is a frequent reproductive problem worldwide, affecting up to 1% of couples. Immune effector cell dysfunction has been implicated in the pathogenesis of early pregnancy loss. This dysfunction may involve defects in cytokines, growth factors and immunosuppressive factors at the maternofetal interface. This is a growing research field, especially the role of cytokines in recurrent miscarriage.

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“…This process is facilitated by the hypotension seen in sepsis. Endotoxins from gram negative bacteria injected 12-14 h apart into rabbits cause the generalized Shwartzman phenomenon [22][23][24], The Shwartzman reaction is regarded as a coagulop athy with massive intravascular coagulation and tissue necrosis, the kidney being the site of predilection. It pro duces microfibrinous thrombosis of afferent arterioles and glomerular capillaries with ensuing renal cortical necrosis.…”

Section: Discussionmentioning

confidence: 99%

Bilateral Renal Cortical Necrosis in Two Patients with <i>Neisseria meningitidis </i>Sepsis

Chervu¹,

Koss²,

Campese³

1991

Am J Nephrol

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Two patients who developed bilateral renal cortical necrosis as a consequence of Neisseria meningitidis infections are described: 1 patient had meningococcemia and the other had meningococcal meningitis. Both patients developed a Shwartzman-like reaction, disseminated intravascular coagulation and irreversible renal failure. Renal biopsy showed sclerosis of the majority of glomeruli; some glomeruli showed capillary congestion, thrombosis and an increased number of neutrophils; the intralobular arterioles showed thrombotic occlusions.

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A New Phenomenon of Local Skin Reactivity to B. Typhosus Culture Filtrate.

Abstract: PLATES 6 AI~' V 7.

Cited by 101 publications

References 3 publications

Bacterial lipopolysaccharide-induced intestinal microvascular lesions leading to acute diarrhea.

Bacterial lipopolysaccharide-induced intestinal microvascular lesions leading to acute diarrhea.

Recurrent miscarriages: What is the role of cytokines?

Bilateral Renal Cortical Necrosis in Two Patients with <i>Neisseria meningitidis </i>Sepsis

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