A new phenolic compound with antioxidant activity from the branches and leaves of Pyrus pashia

Abstract

The branches and leaves of Pyrus pashia are used to cure abdominal pain and diarrhoea in Chinese folk medicine. A new phenilic compound, 4-O-β-d-glucopyranosylbenzyl-benzoate ester (1), along with 21 known ones (2-22) were isolated from the branches and leaves of this plant. Compounds 2 and 3 displayed remarkable antioxidant activities against 1,1-diphenyl-2-picrylhydrazyl radical (IC50 = 13.26 ± 0.04 μM, 13.28 ± 0.11 μM, respectively), which were at the same grade as positive control rutin. The caffeoyl group in compounds 2 and 3 was supposed to play an important role in the antioxidant activities.

Phenolic constituents from Elsholtzia ciliata (Thunb.) Hyland and their NO production inhibition activity

“…Thus, chemical structure of 3 was elucidated as 3 ‐O‐β‐ D‐glucopyranosyl‐1‐(3′,5′‐dimethoxy‐4‐hydroxyphenyl‐1‐propanone). [ 5 ] This was the first isolation of 3 from the Elsholtzia genus.…”

Traditional uses, nutrition, phytochemistry and various pharmacological properties of Indian wild pear (Review)

“…The high antiproliferative activity may be due to high phenolic and flavonoid content and ellagic content (47). Li et al (37) also demonstrated the cytotoxicity of terpenoids (36,37). The aforementioned studies indicate that P. pashia extract has various traditional uses, such as in the treatment of typhoid fever, pain relief and cough, as well as for the treatment of other inflammatory diseases.…”

“…A previous study demonstrated the total phenolics and the free radical scavenging level of methanol and water extracts of leaves; the methanolic leaf extract was shown to have the highest phenolic content (351.16±0.43 mg/g extract) (8). Li et al (37) also demonstrated that the butanol extract of the bark and leaves possessed a high antioxidant level. Overall, the aforementioned studies highlighted the antioxidants level of various plant parts of P. pashia and broadened their applications to prevent degenerative diseases.…”

“…The assigned structures were 2α, 3β, 27-trihydroxyolean-12-en-28-oic acid and (4α)-3-(5, 5-dimethyl tetra hydro furanyl)-1-buten-3-ol 3-O-β-D-glucopyranoside. In another study, Li et al (37) isolated two new cyclic hexapeptides from the branches and leaves of the P. pashia tree. The two compounds, pashinintide A (cyclic hexapeptide, with a saccharose) and pashinintide B (cyclic heptapeptide), were identified based on NMR (one and two-dimensional 1 H, 13 c NMR) spectroscopy and HRE-IMS/HRESIMS.…”

“…That study suggested that pashinintide A [cyclo (-Ala 1 -Gly 2 -Pro 3 -Gly 4 -Trp 5 -Pro 6 -)] can act as a natural receptor for saccharides. The n-butanol extract of leaves exhibited the presence of amburoside A (4-O-b-D-glucopyranosyl benzyl-benzoate ester), an unknown bioactive substance, and 21 known phenolics (37). Among the 22 compounds identified, 3,5-dicaffeoyl quinic acid and methyl 3,5-dicaffeoylquinate exhibited the highest antioxidant activities (Ic 50 , 13.26±0.04 and 13.28±0.11 µM, respectively), which may be due to the caffeoyl group present in these compounds.…”