A new phenolic acid from Zanthoxylum nitidum var. tomentosum (Rutaceae) and its chemotaxonomic significance

Liao, Na; Li, Meishan; Feng, Qicheng; Jiang, Jing-Chen; Luo, Ri-Da; Chen, Xian-Lan; Zhou, Meimei; Zhu, Yan-Kui; Wang, Hengshan

doi:10.1016/j.bse.2021.104351

Cited by 7 publications

(4 citation statements)

References 18 publications

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“…DC. plant (Rutaceae) and named nitomentosin (71) (Figure 16) [115]. The structure of the new compound is similar to that of the known compound O-p-anisoyl-D-tartaric acid, with the methoxy group replaced by hydroxyl and one more carboxylic acid than the known molecule.…”

Section: Polysaccharide (Lps)mentioning

confidence: 76%

New Compounds from Terrestrial Plants: A Perspective View

Oliveira,

Kohatsu,

Hufnagel

et al. 2024

Compounds

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In an era where the search for innovative drug leads faces challenges, our study pivots towards exploring the untapped potential of plant-derived compounds, focusing on the period of 2021 to 2022. We assess the classes of compounds these new structures belong to; the plants and families these compounds belong to; and the degree of novelty of the compound compared with already-known structures. The review was conducted following the Preferred Reporting Items for Systematics Reviews and Meta-Analyses (PRISMA) statement checklist for the guided reporting of systematic reviews. A total of 464 articles were selected for the new compounds of natural origin survey. We included 117 complete articles in this review and reported approximately 109 new structures elucidated during the years 2021 and 2022. Many of the compounds showed small structural variations in relation to already-known molecules. For some, however, this small modification was decisive for the biological activity reported, demonstrating the importance of descriptive phytochemical studies.

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Section: Polysaccharide (Lps)mentioning

confidence: 76%

New Compounds from Terrestrial Plants: A Perspective View

Oliveira,

Kohatsu,

Hufnagel

et al. 2024

Compounds

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“…Among them, Zanthoxylum nitidum (Roxb.) DC., is chiefly distributed in southern China [2] . As a Chinese folk medicine, Z. nitidum has a long history as an analgesic, anti‐inflammatory, and haemostatic medicine, [3] and can promote qi circulation to relieve pain, disperse wind to dredge collaterals, promote blood circulation to remove blood stasis and remove toxicity to achieve detumescence [4–6] .…”

Section: Introductionmentioning

confidence: 99%

“…DC., is chiefly distributed in southern China. [2] As a Chinese folk medicine, Z. nitidum has a long history as an analgesic, antiinflammatory, and haemostatic medicine, [3] and can promote qi circulation to relieve pain, disperse wind to dredge collaterals, promote blood circulation to remove blood stasis and remove toxicity to achieve detumescence. [4][5][6] Therefore, Z. nitidum is frequently used to treat stomachache, toothache, rheumatic arthralgia, traumatic injury, venomous snake bites, burn and scald.…”

Section: Introductionmentioning

confidence: 99%

“…[4][5][6] Therefore, Z. nitidum is frequently used to treat stomachache, toothache, rheumatic arthralgia, traumatic injury, venomous snake bites, burn and scald. [2,7] In our previous work, phytochemical examination of Z. nitidum indicated the presence of alkaloids, amides, cyclic peptides, and lignanoids, which exhibit significant antiproliferative and anti-inflammatory activities. [1,8 -10] As part of a continuing research for natural antiproliferative agents from traditional folk herbs, the bioactive constituents from 95 % EtOH extract of Z. nitidum were explored, which resulted in the purification of 10 compounds (1 -10), including four new sesquiterpenoids (1 -4) as shown in Figure 1, and six known coumarins (5 -10).…”

Section: Introductionmentioning

confidence: 99%

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Four New Sesquiterpenoids from Zanthoxylum nitidum

Feng

et al. 2022

Chemistry & Biodiversity

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Zanthoxylum nitidum (Roxb.) DC., is one of Guangxi's characteristic national medicines, and is the classic Laoban medicine of Yao people “Ru Shan Hu” and Zhuang medicine “Liang Bei Zhen”. It has been used as an anti‐inflammatory, analgesic and haemostatic medicine for thousands of years. In this study, four new sesquiterpenoids (1–4), along with six previously described coumarins (5–10), were isolated from 95 % EtOH extract of Zanthoxylum nitidum. Comprehensive spectroscopic analyses (NMR and HR‐ESI‐MS) were used to elucidate the structures of these isolates. The absolute configurations of nitidumine A–D (1–4) were established by electronic circular dichroism (ECD). Their cytotoxicity of all the isolates against five cancer cell lines (T24, HeLa, MGC‐803, A549, and HepG2) was evaluated by MTT experiment and found not to be cytotoxicity.

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