A new perspective on depression and neuroinflammation: Non-coding RNA

Zhou, Shanyao; Chen, Rui; She, Yanling; Liu, Xuanjun; Zhao, Hui; Cheng, Li; Jia, Yanbin

doi:10.1016/j.jpsychires.2022.02.007

Cited by 23 publications

(13 citation statements)

References 163 publications

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“…In the past few years, a considerable amount of research has been conducted to examine the role of miRNAs in neuropsychiatric disease [147][148][149][150][151][152][153][154][155][156]. We and other investigators have examined the expression of miRNAs in human postmortem brains of depressed subjects, in the brain of animals showing depression-like behavior, and in peripheral tissues such as blood, urine, and saliva [6,96,144,150,[157][158][159][160][161][162][163][164][165][166][167]. We have demonstrated that miRNAs form highly correlated networks in the brains of MDD subjects that differ from healthy controls, suggesting that miRNA networks can give rise to specific behavioral phenotypes [96,168,169].…”

Section: Studies Of Dna Methylation In Adolescents With Elsmentioning

confidence: 99%

Dissecting early life stress-induced adolescent depression through epigenomic approach

Ochi

Dwivedi

2022

Mol Psychiatry

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Early life stress (ELS), such as abuse and neglect during childhood, can lead to psychiatric disorders in later life. Previous studies have suggested that ELS can cause profound changes in gene expression through epigenetic mechanisms, which can lead to psychiatric disorders in adulthood; however, studies on epigenetic modifications associated with ELS and psychiatric disorders in adolescents are limited. Moreover, how these epigenetic modifications can lead to psychiatric disorders in adolescents is not fully understood. Commonly, DNA methylation, histone modification, and the regulation of noncoding RNAs have been attributed to the reprogramming of epigenetic profiling associated with ELS. Although only a few studies have attempted to examine epigenetic modifications in adolescents with ELS, existing evidence suggests that there are commonalities and differences in epigenetic profiling between adolescents and adults. In addition, epigenetic modifications are sex-dependent and are influenced by the type of ELS. In this review, we have critically evaluated the current evidence on epigenetic modifications in adolescents with ELS, particularly DNA methylation and the expression of microRNAs in both preclinical models and humans. We have also clarified the impact of ELS on psychiatric disorders in adolescents to predict the development of neuropsychiatric disorders and to prevent and recover these disorders through personalized medicine.

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Section: Studies Of Dna Methylation In Adolescents With Elsmentioning

confidence: 99%

Dissecting early life stress-induced adolescent depression through epigenomic approach

Ochi

Dwivedi

2022

Mol Psychiatry

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“…Specifically, the T-allele of the rs9563152 SNP, which was associated with increased predisposition to both MDD and insomnia (Table 4), is also associated with reduced expression of RP11-24H2.3 in the anterior cingulate. While the biological relevance of this and of several long non-coding RNAs is not known, this class of transcripts has been increasingly investigated in relation to their potential role in the pathogenesis of psychiatric and neurological disorders [54,55].…”

Section: Discussionmentioning

confidence: 99%

Investigating Shared Genetic Bases between Psychiatric Disorders, Cardiometabolic and Sleep Traits Using K-Means Clustering and Local Genetic Correlation Analysis

2022

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Psychiatric disorders are among the top leading causes of the global health-related burden. Comorbidity with cardiometabolic and sleep disorders contribute substantially to this burden. While both genetic and environmental factors have been suggested to underlie these comorbidities, the specific molecular underpinnings are not well understood. In this study, we leveraged large datasets from genome-wide association studies (GWAS) on psychiatric disorders, cardiometabolic and sleep-related traits. We computed genetic correlations between pairs of traits using cross-trait linkage disequilibrium (LD) score regression and identified clusters of genetically correlated traits using k-means clustering. We further investigated the identified associations using two-sample mendelian randomization (MR) and tested the local genetic correlation at the identified loci. In the 7-cluster optimal solution, we identified a cluster including insomnia and the psychiatric disorders major depressive disorder (MDD), post-traumatic stress disorder (PTSD), and attention-deficit/hyperactivity disorder (ADHD). MR analysis supported the existence of a bidirectional association between MDD and insomnia and the genetic variants driving this association were found to affect gene expression in different brain regions. Some of the identified loci were further supported by results of local genetic correlation analysis, with body mass index (BMI) and C-reactive protein (CRP) levels suggested to explain part of the observed effects. We discuss how the investigation of the genetic relationships between psychiatric disorders and comorbid conditions might help us to improve our understanding of their pathogenesis and develop improved treatment strategies.

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“…Neuroinflammation is a hallmark widely associated with several neurological and neuropsychiatric diseases, such as depression and Alzheimer’s disease. By regulating the production of immune factors and immune cell activation, neuroinflammation assumes an important role in depression [ 40 ]. There is a positive relationship between antidepressant therapy/psychotherapy and the reduction of inflammatory signs, highlighting the connection between depression and inflammatory processes [ 41 ].…”

Section: Trp Metabolism In Depression—an Overlookmentioning

confidence: 99%

Tryptophan Metabolism in Depression: A Narrative Review with a Focus on Serotonin and Kynurenine Pathways

Correia

Vale

2022

IJMS

107

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Depression is a common and serious disorder, characterized by symptoms like anhedonia, lack of energy, sad mood, low appetite, and sleep disturbances. This disease is very complex and not totally elucidated, in which diverse molecular and biological mechanisms are involved, such as neuroinflammation. There is a high need for the development of new therapies and gaining new insights into this disease is urgent. One important player in depression is the amino acid tryptophan. This amino acid can be metabolized in two important pathways in the context of depression: the serotonin and kynurenine pathways. These metabolic pathways of tryptophan are crucial in several processes that are linked with depression. Indeed, the maintenance of the balance of serotonin and kynurenine pathways is critical for the human physiological homeostasis. Thus, this narrative review aims to explore tryptophan metabolism (particularly in the serotonin and kynurenine pathways) in depression, starting with a global overview about these topics and ending with the focus on these pathways in neuroinflammation, stress, microbiota, and brain-derived neurotrophic factor regulation in this disease. Taken together, this information aims to clarify the metabolism of tryptophan in depression, particularly the serotonin and kynurenine pathways.

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A new perspective on depression and neuroinflammation: Non-coding RNA

Cited by 23 publications

References 163 publications

Dissecting early life stress-induced adolescent depression through epigenomic approach

Dissecting early life stress-induced adolescent depression through epigenomic approach

Investigating Shared Genetic Bases between Psychiatric Disorders, Cardiometabolic and Sleep Traits Using K-Means Clustering and Local Genetic Correlation Analysis

Tryptophan Metabolism in Depression: A Narrative Review with a Focus on Serotonin and Kynurenine Pathways

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