A new perspective of hypothalamic disease: Shapiro's syndrome

Abstract

Shapiro's syndrome (SS) is characterized by spontaneous periodic hypothermia. It occurs to patients regardless of age or sex. To date, <60 cases have been reported worldwide. Current knowledge of the disease is limited to clinical feature since the pathogenesis and etiology are still controversial. In this review, the clinical characteristics, pathological mechanism, and possible etiology of the syndrome were reviewed to improve the clinical understanding of the disease.

Untitled

“…Neurodegenerative, genetic, immune and infectious diseases are the main causes of SS. 69 SS patients may have episodes of hyperhidrosis (Swidyati) especially on the face and upper body (Greeva, Lalata & Hrudaya) followed by profound hypothermia (32-33 °C) (Sheetalam). 70 Episodes of hyperthermia (Ushna) and hypothermia (Sheetalam) repeat in patient with SS.…”