A new perspective of Ferroptosis in People with Psoriasis and Psoriatic Arthritis basing on a bioinformatics analysis

Abstract

Patients with psoriasis (Ps) and psoriatic arthritis (PsA) are reported with increased cancer risk, but the underlying correlation in less clear. This study was performed to identify the possible association of ferroptosis with Ps and PsA using bioinformatics methods. Differentially expressed genes (DEGs) were identified between blood samples from patients with PsA and Ps as well as normal control (CL), and the overlapped as well as merged DEGS between the two sets were used for further analysis including the hub genes exploration, enrichment analysis, interaction network construction and engaged pathway analysis. The expression level of ferroptosis related genes among above two sets were performed and the association of key ferroptosis related genes and hub genes was explored to clarify whether ferroptosis correlated with Ps and PsA. The findings revealed a correlation between ferroptosis regulatory genes and hub genes in both Ps and PsA groups, and it appeared to be stronger in the PsA group. Furthermore, most of the correlations are negative. And the similar results were found in the validation dataset. In conclusion, ferroptosis may be a potential research point in psoriasis and psoriasis arthritis development and increased cancer risk.