A New Perspective in the Treatment of Ischemic Stroke: Ferroptosis

Zhang, Lei; Bai, Xin Yue; Sun, Ke Yao; Li, Xuan; Zhang, Zhao Qi; Liu, Yi Ding; Xiang, Yang; Liu, Xiao Long

doi:10.1007/s11064-023-04096-3

Cited by 4 publications

(2 citation statements)

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“…Epithelial Antigen of Prostate 3 (STEAP3) enzyme, Divalent Metal Transporter 1 (DMT1), and Nuclear receptor coactivator 4 (NCOA4) ( Gryzik et al, 2021 ), Membrane iron transport protein 1 (Ferroportin1, FPN1), Ferritin, Promimin 2, Ceruloplasmin (CP), etc. are involved in the transport to cells and participate in the reaction in vivo ( Scarpellini et al, 2023 ; Zhang et al, 2024a ). However, the excess of Fe 2+ in the organism under certain pathological conditions, on the one hand, induces the accumulation of ROS in the body through the Fenton reaction; on the other hand, iron participates in the catalytic process of metabolic enzymes, such as LOX, as a cofactor of various phospholipid peroxidases, which in turn accelerates lipid peroxidation and induces ferroptosis ( Du and Guo, 2022 ; Sun et al, 2023 ) (e.g., Figure 1 ).…”

Section: Small Molecule Ferroptosis Inhibitorsmentioning

confidence: 99%

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Ferroptosis inhibitors: past, present and future

Zhang,

Luo,

Xiang

et al. 2024

Front. Pharmacol.

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Ferroptosis is a non-apoptotic mode of programmed cell death characterized by iron dependence and lipid peroxidation. Since the ferroptosis was proposed, researchers have revealed the mechanisms of its formation and continue to explore effective inhibitors of ferroptosis in disease. Recent studies have shown a correlation between ferroptosis and the pathological mechanisms of neurodegenerative diseases, as well as diseases involving tissue or organ damage. Acting on ferroptosis-related targets may provide new strategies for the treatment of ferroptosis-mediated diseases. This article specifically describes the metabolic pathways of ferroptosis and summarizes the reported mechanisms of action of natural and synthetic small molecule inhibitors of ferroptosis and their efficacy in disease. The paper also describes ferroptosis treatments such as gene therapy, cell therapy, and nanotechnology, and summarises the challenges encountered in the clinical translation of ferroptosis inhibitors. Finally, the relationship between ferroptosis and other modes of cell death is discussed, hopefully paving the way for future drug design and discovery.

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Section: Small Molecule Ferroptosis Inhibitorsmentioning

confidence: 99%

“…Pharmacological evaluation of ACSL4 revealed that GPX4KO mice treated with ROSI showed better inhibition of ferroptosis ( Doll et al, 2017 ). In addition, thrombin inhibitors also inhibit ACLS4 and ferroptosis ( Zhang et al, 2024a ).…”

Section: Small Molecule Ferroptosis Inhibitorsmentioning

confidence: 99%