A New Peptide-Based Method for the Design and Synthesis of Nanoparticle Superstructures: Construction of Highly Ordered Gold Nanoparticle Double Helices

Chen, Chun-Long; Zhang, Peijun; Rosi, Nathaniel L.

doi:10.1021/ja805683r

Cited by 345 publications

(462 citation statements)

References 40 publications

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“…25 These monolayers can also be stacked and arranged in alternating molecular patterns through layerby-layer deposition. [26][27][28] Another means that may be amenable for attaching macromolecular DNA or RNA is by coating the gold surface with alternating layers of cationic and anionic polyelectrolytes. 29 Synthesizing DNA or peptide linkers between GNPs confer these building blocks with programmable spatial coordinates.…”

mentioning

confidence: 99%

Functionalized gold nanoparticles for the binding, stabilization, and delivery of therapeutic DNA, RNA, and other biological macromolecules

DeLong¹,

Wanekaya²,

Reynolds³

et al. 2010

NSA

179

102

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Nanotechnology has virtually exploded in the last few years with seemingly limitless opportunity across all segments of our society. If gene and RNA therapy are to ever realize their full potential, there is a great need for nanomaterials that can bind, stabilize, and deliver these macromolecular nucleic acids into human cells and tissues. Many researchers have turned to gold nanomaterials, as gold is thought to be relatively well tolerated in humans and provides an inert material upon which nucleic acids can attach. Here, we review the various strategies for associating macromolecular nucleic acids to the surface of gold nanoparticles (GNPs), the characterization chemistries involved, and the potential advantages of GNPs in terms of stabilization and delivery.

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mentioning

confidence: 99%

Functionalized gold nanoparticles for the binding, stabilization, and delivery of therapeutic DNA, RNA, and other biological macromolecules

DeLong¹,

Wanekaya²,

Reynolds³

et al. 2010

NSA

179

102

View full text Add to dashboard Cite

show abstract

“…These studies were extended to the formation of multi-component structures composed by a central QD and a discrete number of Au NCs (one to seven) attached to it [74]. Similarly, the direct assembly of NCs, often monocomponent, was achieved by using antibodies, peptides [75,76], and organic molecules [77,78] which led to well-defined arrays of dimers, trimers, tetramers and other superstructures of NCs. More recently, the complexity of these structures was extended to the control of its composition, showing the possibility to combine metal and semiconductor NCs into oligomeric structures either through chemical reactions of active groups present in organic molecules at their surface [79,80] or using proteins as a templates [81].…”

Section: Hybrid Nanostructuresmentioning

confidence: 99%

Exploring New Synthetic Strategies for the Production of Advanced Complex Inorganic Nanocrystals

Bastús

González

Esteve

et al. 2014

Zeitschrift Für Physikalische Chemie

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Abstract:The design of new protocols for the colloidal synthesis of complex nanocrystals (NCs) with advanced functionalities, comprising both hybrid and hollow structures, and the study of their fundamental properties is of paramount importance for the development of a new generation of nanostructured materials. The possibility of tailoring the dimensional regime of NCs, along with its composition and structure, represents a landmark achievement in the control of their unique physico-chemical properties. These properties, alongside with the ability to cheaply produce high quality NCs in fairly large amounts by wetchemistry techniques, leads to their potential applicability from materials science to nanomedicine. Within this context, this review is focused on describing a successful framework for designing synthetic strategies for the production of advanced complex NCs, integrating the development of new synthetic methods with its structural characterization, monitoring of their properties, and study of its reactivity. As a result, it is expected to provide new routes to produce robust and easy-to-process NCs in a wide range of sizes, shapes and configurations that can be explored to achieve the combination of all degrees of control, aiming to produce a complete and diverse library of material combinations that will expand its applicability in a wide diversity of fields.

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“…By engineering an interaction between the two, Alivisatos et al pioneered the decoration of DNA templates with surface-modified gold NPs, producing dimers and trimers of well-defined separations [ 1 ]. Similarly, Chen et al used a chemically modified peptide to reduce a gold salt, resulting in a left-handed arrangement of gold NPs along the peptide backbone [ 127 ] as is shown in Figure 4 (A). The introduction of chirality to the organization of plasmonic NPs produces optically active materials and gives an additional means to tune the optical properties of such systems.…”

Section: Referential Fabrication Techniquesmentioning

confidence: 99%

Self-assembled plasmonic metamaterials

et al. 2013

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Nowadays for the sake of convenience most plasmonic nanostructures are fabricated by top-down nanofabrication technologies. This offers great degrees of freedom to tailor the geometry with unprecedented precision. However, it often causes disadvantages as well. The structures available are usually planar and periodically arranged. Therefore, bulk plasmonic structures are difficult to fabricate and the periodic arrangement causes undesired effects, e.g., strong spatial dispersion is observed in metamaterials. These limitations can be mitigated by relying on bottom-up nanofabrication technologies. There, self-assembly methods and techniques from the field of colloidal nanochemistry are used to build complex functional unit cells in solution from an ensemble of simple building blocks, i.e., in most cases plasmonic nanoparticles. Achievable structures are characterized by a high degree of nominal order only on a shortrange scale. The precise spatial arrangement across larger dimensions is not possible in most cases; leading essentially to amorphous structures. Such self-assembled nanostructures require novel analytical means to describe their properties, innovative designs of functional elements that possess a desired near-and far-field response, and entail genuine nanofabrication and characterization techniques. Eventually, novel applications have to be perceived that are adapted to the specifics of the self-assembled nanostructures. This review shall document recent progress in this field of research. Emphasis is put on bottom-up amorphous metamaterials. We document the state-of-the-art but also critically assess the problems that have to be overcome.

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A New Peptide-Based Method for the Design and Synthesis of Nanoparticle Superstructures: Construction of Highly Ordered Gold Nanoparticle Double Helices

Cited by 345 publications

References 40 publications

Functionalized gold nanoparticles for the binding, stabilization, and delivery of therapeutic DNA, RNA, and other biological macromolecules

Functionalized gold nanoparticles for the binding, stabilization, and delivery of therapeutic DNA, RNA, and other biological macromolecules

Exploring New Synthetic Strategies for the Production of Advanced Complex Inorganic Nanocrystals

Self-assembled plasmonic metamaterials

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