A new pentacyclic triterpenoid from the leaves of <i>Lantana montevidensis</i> (Spreng.) Briq.

Makboul, Makboul A.; Attia, A. A.; Farag, Sherif; Mohamed, Nesma M.; Ross, Samir A.; Takaya, Yoshiaki; Niwa, Masayuki

doi:10.1080/14786419.2013.824443

Cited by 13 publications

(10 citation statements)

References 19 publications

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“…Based on previous research, the pentacyclic‐type triterpenoids showed certain antibacterial activities . Therefore, the minimum inhibitory concentrations ( MIC ) of antibacterial activities of the isolates were tested.…”

Section: Resultsmentioning

confidence: 99%

Six New Pentacyclic Triterpenoids from the Fruit of Camptotheca acuminata

Chen

Zhang

et al. 2016

Chemistry & Biodiversity

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Six new pentacyclic triterpenoids were isolated from the fruit of Camptotheca acuminata. The chemical structures of the new compounds were elucidated by extensive spectroscopic analysis including HR-ESI-MS, IR, UV, 1D- and 2D-NMR. Moreover, the antibacterial activities of compounds 1, 2, 4, 5, and 6 were evaluated against Staphylococcus aureus, Escherichia coli, Bacillus subtilis and Dickeya zeae. All these tested compounds showed moderate antibacterial activity against Bacillus subtilis and Dickeya zeae.

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Section: Resultsmentioning

confidence: 99%

Six New Pentacyclic Triterpenoids from the Fruit of Camptotheca acuminata

Chen

Zhang

et al. 2016

Chemistry & Biodiversity

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“…4,9 Our previous phytochemical study on 70% methanolic extract of L. montevidensis leaves led to the isolation of pentacyclic triterpenoids. 10 In continuation of our investigation, we report herein the isolation and identification of seven flavonoids (1)(2)(3)(4)(5)(6)(7) in addition to salicylic acid (8) and β-sitosterol-3-O-glucoside (9). Furthermore, some of the isolated flavonoids were evaluated for their free radical scavenging activity.…”

Section: Introductionmentioning

confidence: 91%

“…(5 kg) were extracted with 70% aqueous methanol and fractionated with n-hexane, CHCl 3 , EtOAc and n-BuOH as described previously. 10 About 30 g of the EtOAc extract was fractionated on silica gel column (900 g, 150 cm × 5 cm). Elution was performed using CHCl 3 -MeOH gradient, where four groups were obtained: E-I (5.5 g, eluted with CHCl 3 -MeOH 95:5), E-II (7 g, CHCl 3 -MeOH 90:10), E-III (12 g, CHCl 3 -MeOH 80:20) and E-IV (3 g, CHCl 3 -MeOH 70:30).…”

Section: Extraction and Isolationmentioning

confidence: 99%

Chemical Constituents with Free-Radical- Scavenging Activity from the Leaves of Lantana montevidensis (Spreng.) Briq.

Makboul¹,

Attia²,

Farag³

et al. 2014

phcog J

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Background: Seventy percent aqueous methanolic extract of the leaves of Lantana montevidensis exhibited antibacterial, anti-inflammatory, anti-pyretic, antioxidant, and analgesic activities. Previous phytochemical study of the leaves led to the isolation of various flavones, pentacyclic triterpenoids, β-sitosterol and benzoic acid. Materials and Methods: The 70% aqueous methanolic extract of L. montevidensis (Spreng.) Briq. leaves was partitioned between water and n-hexane, ChCl 3 , etOac, and n-BuOh, successively. By using a series of different chromatographic techniques, the ChCl 3 and EtOAc extracts afforded nine compounds. The isolated compounds were identified by spectroscopic techniques and by comparison with literature values and/or authentic samples. the free radical scavenging activity of some of the isolated compounds was evaluated. Results: Hispidulin-7-O-glucurnoide methyl ester (1), hispidulin-7-O-glucoside (2), cinaroside (3), nepetin-7-O-glucoside (4) pectolinarigenin (5), apigenin (6), luteolin (7) in addition to salicylic acid (8) and β-sitosterol-3-O-glucoside (9) have been isolated. Compounds 1-4 are first report from the genus Lantana, whereas compounds 5, 8 and 9 are first report from this plant. The structures of these compounds were elucidated on the basis of spectral methods, including 2D nuclear magnetic resonance experiments, and confirmed by comparing with the literature data and/or authentic samples. Additionally, some of the isolated flavonoids exhibited free radical scavenging activity. Conclusion: L. montevidensis (Spreng.) Briq. cultivated in egypt is rich in biologically active ingredients.

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“…Phytochemical studies revealed that the flavonoid fraction from the leaves of L. montevidensis exhibits antiproliferative activity against human gastric adenocarcinoma, human uterine carcinoma and murine melanoma cell lines (Nagão et al, 2002[26]). Triterpenoids and flavones are likely to be the major components of L. montevidensis leaves extracts (Makboul et al, 2013[23]), while β-caryophyllene, germacrene and bicyclogermacrene are the main constituents of its essential oil (Sousa et al, 2013[35]). …”

Section: Introductionmentioning

confidence: 99%