A new patch test preparation of dust mites for atopic dermatitis

Gaddoni, Giuseppe; Baldassari, Laura E.; Zucchini, A.

doi:10.1111/j.1600-0536.1994.tb01948.x

Cited by 12 publications

(12 citation statements)

References 7 publications

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“…Recently, Seidenari et al [32 ]have observed positive responses to mite patch tests also in subjects with respiratory atopy and nonatopic subjects without AD, but with a frequency and intensity significantly lower compared to AD patients. In the present work, we have detected a rate of positivity in our patients with AD roughly comparable to rates observed in AD patients by other authors and by us in the past, when the same allergen extracts were employed [11, 13, 19, 20, 23, 24, 32], and we have confirmed in agreement with Seidenari et al [32] that the APT is positive also in AWE and NA subjects, with a frequency significantly lower than in AD patients. Moreover, the evaluation of reading scores confirmed a significant difference of intensity in APT responses in AD patients.…”

Section: Discussionsupporting

confidence: 70%

“…No positive APT responses to aeroallergens in patients with respiratory atopy or controls were detected by Darsow et al [3]. On the contrary, rates of positivities ranging from 5 to 40% in AWE [5, 6, 8, 11, 18, 24] and healthy subjects [6, 8, 9,11,12,13,18,19,20,22,23,24] were reported in the past by other authors. Recently, Seidenari et al [32 ]have observed positive responses to mite patch tests also in subjects with respiratory atopy and nonatopic subjects without AD, but with a frequency and intensity significantly lower compared to AD patients.…”

Section: Discussionmentioning

confidence: 81%

“…However, small numbers of positive APT were reported in the past also in atopic subjects without dermatitis [6, 8,18,19,20, 23, 24] and in healthy persons [5, 9, 11, 13,18,19,20, 23, 24] and that would raise some question about the specificity and the clinical relevance of positive APT results. …”

Section: Introductionmentioning

confidence: 99%

“…Many studies on the APT have been performed [1,2,3,4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24], and it is regarded quite specific for patients with AD. However, small numbers of positive APT were reported in the past also in atopic subjects without dermatitis [6, 8,18,19,20, 23, 24] and in healthy persons [5, 9, 11, 13,18,19,20, 23, 24] and that would raise some question about the specificity and the clinical relevance of positive APT results.…”

Section: Introductionmentioning

confidence: 99%

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Is the Atopy Patch Test with House Dust Mites Specific for Atopic Dermatitis?

Ingordo

Nogare²,

Colecchia³

et al. 2004

Dermatology

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Background: The atopy patch test (APT), namely the patch test with aeroallergens, is regarded as specific for patients with atopic dermatitis (AD), but small numbers of positive APT were reported in the past also in atopic subjects without dermatitis and in healthy persons. Objective: The aim of this study was to evaluate the response to the APT with house dust mites (HDM) in subjects nonaffected by AD and to compare the outcomes observed in these cases with those pointed out in AD patients, evaluating also the differences between two allergen extracts manufactured at different purifications and concentrations. Methods: Forty-seven atopic subjects without eczema (AWE), 33 nonatopic (NA) subjects and 77 adult AD patients were patch tested with an extract of purified bodies of HDM at 20% and with another extract of whole bodies of HDM at 30%, the latter corresponding to 300 µg/g of Der p 1. The reproducibility of APT was also tested in 8 AD patients, in 37 AWE subjects and in 19 NA subjects. Results: Positive responses with extract at 20% were observed in 29 (37.7%) AD, in 5 (10.6%) AWE and in 4 (12.1%) NA subjects. The APT with HDM at 30% was positive in 32 (41.6%) AD, 9 (19.1%) AWE and 4 (12.1%) NA persons. The rates of positivity and the intensity scores of responses were significantly different between AD and non-AD subjects (p < 0.01). The reproducibility of the APT in the three groups was satisfactory. Conclusion: These observations lead to conclude that the APT with HDM is positive also in non-AD subjects but it is probably more specific for AD.

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Section: Discussionsupporting

confidence: 70%

Section: Discussionmentioning

confidence: 81%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Is the Atopy Patch Test with House Dust Mites Specific for Atopic Dermatitis?

Ingordo

Nogare²,

Colecchia³

et al. 2004

Dermatology

View full text Add to dashboard Cite

show abstract

“…Many studies on APT have been performed 6–8,10–28 . In these reports the percentages of positive subjects varied from 15% to 100% 18,22 , 26–28 and the variations are ascribed to the lack of standardized techniques and the different purification of allergens 8,29 , 30 .…”

Section: Discussionmentioning

confidence: 99%