A New Paradigm for the Role of Aging in the Development of Skin Cancer

Skin resurfacing procedures: new and emerging options

“…Recently, the increased susceptibility of elderly patients to developing NMSC was described to be due in part to the failure of geriatric skin to respond appropriately to ultraviolet B (UVB) irradiation found in sunlight 76. This inappropriate UVB response represents a failure of the protective properties found in young skin that halts the propagation of UVB-induced mutations in basal layer keratinocytes 77,78. The appropriate protective UVB response in young skin is mediated by insulin-like growth factor-1 (IGF-1) secreted from dermal fibroblasts.…”

“…This UVB response is deficient in geriatric skin due to an increasing proportion of senescent dermal fibroblasts resulting in a silencing of dermal IGF-1 production. It is this inappropriate UVB response observed in geriatric skin that allows DNA mutations to propagate in proliferating basal keratinocytes, thus initiating photocarcinogenesis 77,78. Importantly, restoration of dermal IGF-1 expression could prevent the initiation of UVB-induced carcinogenesis by restoring this secretion of dermal IGF-1.…”

How Wounding via Lasers Has Potential Photocarcinogenic Preventative Effects via Dermal Remodeling

“…It is logical to target basic science efforts to examine signaling pathways frequently disturbed in geriatric skin following UVB irradiation. The insulin-like growth factor-1/insulin-like growth factor-1 receptor (IGF-1/IGF-1R) pathway (6–8) is one such pathway. Recent published reports have shown that the severity of DNA damage in keratinocytes directly correlates to the intensity of UVB exposure and that the state of activation of the IGF-1/IGF-1R pathway is critical to propensity of one to develop the NMSC.…”

“…Unfortunately, the geriatric keratinocytes due to inactivity of protective IGF-1R signaling are not able to induce senescent response under the same dose of UVB. This biological misfortune causes them to propagate UVB-induced DNA damage and ultimately induce neoplastic transformation in keratinocytes (6,8). …”

A hedonic response to an assay made on octogenarians using cosmetics that promise to donate comfort, attractiveness and youth

“…It is noticeable a -1% dermal collagen collapse per year, and moreover (especially in female) collagen is calcified by Calcium ions originating from ostheoporosis, that include a severe Calcium loss from bones [5][6][7][8][9][10][11][12][13][14][15][16][17].…”