2004
DOI: 10.1039/b408863h
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A new packing motif for para-sulfonatocalix[4]arene: the solid state structure of the para-sulfonatocalix[4]arene d-arginine complex

Abstract: The solid-state structure of the complex of para-sulfonatocalix[4]arene with d-arginine, contains a water channel diagonal to a zigzag bilayer of the host, within the bilayer six crystallographically independent molecules of arginine are present, four being included in the calix cavities.

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Cited by 58 publications
(65 citation statements)
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“…For example, they can be functionalised to yield multivalent ligands that promote specific binding . Considering the propensity of sulfonato‐calix[4]arene (sclx 4 ) to encapsulate lysine or arginine we have focused our attention on this ligand. Previously, we demonstrated that the four‐fold symmetric sclx 4 can bind to several sites on cytochrome c .…”
Section: Introductionmentioning
confidence: 99%
“…For example, they can be functionalised to yield multivalent ligands that promote specific binding . Considering the propensity of sulfonato‐calix[4]arene (sclx 4 ) to encapsulate lysine or arginine we have focused our attention on this ligand. Previously, we demonstrated that the four‐fold symmetric sclx 4 can bind to several sites on cytochrome c .…”
Section: Introductionmentioning
confidence: 99%
“…Hence, neither SC4 and its derivatives nor C4diP show any inhibitory effects, this would imply that binding to more than one amino acid residue is required for enzyme inhibition. The solid-state structures of SC4 with Lys [40] or Arg [41] confirm that this system only binds a single amino acid. For the larger systems, SC6 and SC8 inhibitory effects occur for the SCNa molecules; this would be in line with binding to pharmacophore pockets 1 and 6, as shown in Figure 7 below.…”
Section: Discussionmentioning
confidence: 69%
“…While there is considerable literature on the inclusion properties of SCX4 and SCX6, many of the papers focus on complexes with a potential biological importance [ 27 , 33 , 34 , 35 , 36 ]. Calixarene binding to the OP VX has been reported [ 19 ] and, as we have demonstrated, the formation of host–guest inclusion complexes of the OP nerve agent GD and commonly used simulants with SCX4 and SCX6 is clearly feasible.…”
Section: Resultsmentioning
confidence: 99%