A new oxo-sterol derivative from the rhizomes of <i>Costus speciosus</i>

Kumar, Ashish; Chand, Gopi; Agnihotri, Vijai K.

doi:10.1080/14786419.2017.1324962

Cited by 16 publications

(6 citation statements)

References 10 publications

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“…Fatty Acid: Hexadecanoic acid, 9, 12 octadecanoic acid, tetradecanoic acid, and oleic acid can enhance insulin production in INS-1. 52 TNF-alpha inhibits insulin production but pre-treatment with oleic acid reverses the inhibitory activity. Thus glucose level is decreased.…”

Section: Proteinsmentioning

confidence: 99%

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2019

IJPSR

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Objective: Diabetes mellitus is an interminable metabolic disorder that has highly affected human health and quality of life. Conventional agents are being applied to control this disorder along with lifestyle management. But they are not totally effective and nobody has ever been diagnosed with full recovery of diabetes. Medicinal plants have been used for greater extent for control of diabetes mellitus in various traditional system of medicine worldwide as they are of natural origin and many of them are known to be effective against diabetes. Costus igneus is known as a blazing Costus, step stepping stool or Spiral banner. In India, it is popularly known as insulin plant due to the consumption of leaves of Costus igneus helps to prevent diabetes mellitus by decreasing the blood glucose level. A comprehensive review was conducted to collect data about medicinal herbs used for the treatment of diabetes mellitus. This review deals with the study of chemical structures of plant constituents and their mechanism of action. Materials and Methods: Review is mainly focused on Costus igneus especially on its anti-diabetic activity. Result: Reviews suggest that Costus igneus has anti-diabetic potential especially on diabetes mellitus. Conclusion: Considering the ability of the valuable things present in Costus igneus, this review is aimed to summarize the information of the biochemical constituents, their chemical structures, and mode of action. Due to the high therapeutic potential, these bio-compounds deserve special attention.

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Section: Proteinsmentioning

confidence: 99%

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2019

IJPSR

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“…The diuretic index values of rhizome extract at a dose of 200 mg/kg and 400 mg/kg were 3.25, 1.25, respectively, indicating a weak diuretic activity of the extract compared with furosemide standard. Lijuan et al reported that 10 mg/100 mL rhizome extract of C. speciosus stimulates urination properties in rats [20].…”

Section: Diuretic Activitymentioning

confidence: 99%

Molecular docking supported investigation of antioxidant, analgesic and diuretic effects of Costus speciosus rhizome

Naznin¹,

Mazumder²,

Reza³

et al. 2022

Bull. Chem. Soc. Eth.

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ABSTRACT. The aim of the current study was to analyze the polyphenols and determines the antioxidant, analgesic and diuretic properties of the methanolic extract of C.speciosus rhizome. DPPH and ferric reducing antioxidant power (FRAP) assays were used to determine the antioxidant activity. Acetic acid-induced writhing and formalin-induced licking experiments were used to assess the analgesic effect. The total phenolic, flavonoid and flavonol contents were found 51.73± 0.25 mg GAE/g dry weight, 3.41± 0.07mg QE/g dry weights and 44.19± 2.24 mg QE/g dry weight, respectively. The plant extract exhibited weak antioxidant activity in the DPPH and FRAP assays, with an IC50 value of 1699±62 μg/mL and an EC50 value of 125±2 μg/mL, respectively. The extract significantly reduced the number of writhes at both doses (200 and 400 mg/kg body weight) as compared to the control. The extract (400 mg/kg) also significantly reduced the percent inhibition of licking by 31.96 and 62.69% compared to the control in the early and late phase, respectively. Compared to the standard drug furosemide, the plant extract also showed a weak diuretic effect. The docking study supported the analgesic activity of rhizome extract. The potent analgesic activity of the plant extract justifies the traditional and medicinal aspects. KEY WORDS: Costus speciosus, Analgesic activity, Diuretic effect, Molecular docking Bull. Chem. Soc. Ethiop. 2022, 36(3), 627-640. DOI: https://dx.doi.org/10.4314/bcse.v36i3.12

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“…Department of Agriculture, 2016). Updated findings of each plant species were also referred (Al-Snafi, 2018;Bagalkotkar et al, 2006;El-far AH, Shaheen, HM, Alsenosy, AW, El-Sayed YS, Al Jaouni SK, Mousa, 2018;Jadhav et al, 2009;Kamruzzaman and Hoq, 2016;Kumar et al, 2018bKumar et al, , 2018aMissoum, 2018;Mohamad et al, 2018;Narendra et al, 2012;Pawar and Pawar, 2014;Qiao et al, 2002;Rani et al, 2012;Salem et al, 2014;Thabit, 2018;Thambi and Shafi, 2015;Waisundara et al, 2015) and compiled into a list of compounds (Supplementary Table 1). Compounds that do not possess the canonical simplified molecular-input line-entry system (SMILES) in PubChem were removed.…”

Section: Prediction Of Bioactive Compounds and Target Genesmentioning

confidence: 99%

Network pharmacology approach to reveals therapeutic mech-anism of traditional plants formulation used by Malaysia in-digenous ethnics in coronaviruses infection

Lem

Lee

Chee

et al. 2022

Preprint

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Network pharmacology analysis can act as a strategy to identify the pharmacological effect of plant-based bioactive compounds against coronavirus diseases. This study aimed to investigate the potential pharmacological mechanism of a local ethnomedicine (Costus speciosus, Hibiscus rosa-sinensis and Phyllanthus niruri) of Northern Borneo against coronaviruses known as CHP. Compounds in CHP were extracted from databases and screened for their oral bioavailability and drug-likeness before a compound-target network was built. Furthermore, the protein-protein interaction network and pathway enrichment were constructed and analyzed. A compound-target network consisting of 48 putative bioactive compounds targeting 587 candidate genes was identified. A total of 186 coronavirus-related genes were extracted and TP53, STAT3, HSP90AA1, STAT1, and EP300 were predicted to be the key targets. Notably, mapping of these target genes into the target-pathway network illustrated that functional enrichment was on viral infection and regulation of inflammation pathways. Urinatetralin is predicted, for the first time, as a bioactive compound that solely targets STAT3. The results from this study indicate that compounds present in CHP employ STAT3 and its connected pathways as the mechanism of action against coronaviruses. In conclusion, urinatetralin should be further investigated for its potential application against coronavirus infections.

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A new oxo-sterol derivative from the rhizomes of Costus speciosus

Cited by 16 publications

References 10 publications

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Molecular docking supported investigation of antioxidant, analgesic and diuretic effects of Costus speciosus rhizome

Network pharmacology approach to reveals therapeutic mech-anism of traditional plants formulation used by Malaysia in-digenous ethnics in coronaviruses infection

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