A New "One-Minute" Treatment of Gonorrhoea

A survey of problems in the antibiotic treatment of gonorrhoea. With special reference to South-East Asia.

“…higher for chlortetracycline - Table IX). The problem strains tended to be somewhat more resistant to spiramycin, which has had some use in the region by single session therapy (Siboulet and Durel, 1961), than to tetracycline (Table XIII; see also Fig. 3), but they were still sensitive to erythromycin and chloramphenicol (Table XIV), although there is a suggestion that this situation may alter with erythromycin (Table XIV).…”

“…Combined with tetracycline in 'Sigmamycin' Ineffective in single doses of up to 2 g. (Willcox, 1956) Widely used in France in single doses of 2 5 g. with up to 97 per cent. cure rate (Siboulet and Durel, 1961) Results less striking in other areas (Clarke, 1964; Schmidt and others, 1965) Doses of 3-4 g. spread over 1 to 2 days have been completely successful (Willcox, 1956) Disadvantages and comment…”

Fascinating Giardia Lamblia and Vexing Chronic Spontaneous Urticaria: An Under-appreciated Association

“…In the present study, it was administrated, under supervision, to all Giardia positive cases (n=14) as single oral dose with guaranteed compliance, in fact a "One Minute Treatment" [21].…”

Secnidazole. A 5-nitroimidazole derivative with a long half-life.

“…Recent studies by French workers in Paris, Corsica, and Senegal showed that 20 to 25 % of women and 15 % of men who have a non-gonococcal genital infection are infected by this parasite (Nicoli et al, 1964;Ridet and Siboulet, 1974-75, unpublished;Bohbot, 1975). As a result of this work and because of the current epidemiological need for a single-dose treatment (treatment 'within a minute') (Siboulet and Durel, 1961;Csonka, 1971), the interest of clinicians has been focused on new products. Two studies, one clinical and one laboratory, have been carried out in parallel on a new derivative of 5-nitroimidazole-14 539 RP or secnidazole.…”