A new ocotillol-type ginsenoside from stems and leaves of <i>Panax quinquefolium</i> L. and its anti-oxidative effect on hydrogen peroxide exposed A549 cells

Zeng, Qi; Wang, Zhenzhou; Zhou, Baisong; Fu, Shuilian; Hong, Tian; Li, Pingya; Liu, Jinping

doi:10.1080/14786419.2018.1543677

Cited by 14 publications

(9 citation statements)

References 15 publications

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“…Final DMSO concentration in the sample was less than 0.1%. Cell culture and MTT assay were done as we described previously to evaluate 24 h-incubation of triterpenoids or the 18 h-incubation of CSE on the cell viability of A549 cells [6].…”

Section: Methodsmentioning

confidence: 99%

“…Western blot assay was performed as previous described [6] to study the effects of ginsengenin-S2 on the protein expression of HDAC2 and Nrf2 in CSE-stimulated A549 cells. Anti-HDAC2 (#ab32117), anti-Nrf2 (#ab137550) and anti-β-actin (#ab137550) were from Abcam Company (Cambridge, UK).…”

Section: Methodsmentioning

confidence: 99%

“…However, chemical research of the pearl knots of PGS remains poorly understood. Ginsenosides, the main active principle of Panax ginseng , possesses various pharmacological activities including antioxidant [6], immunomodulatory [7], neuroprotective [8], anti-depressive effects [9,10] and renal protective effect [11].…”

Section: Introductionmentioning

confidence: 99%

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Four Novel Dammarane-Type Triterpenoids from Pearl Knots of Panax ginseng Meyer cv. Silvatica

Guan

et al. 2019

Molecules

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Panax ginseng Meyer cv. Silvatica (PGS), which is also known as “Lin-Xia-Shan-Shen” or “Zi-Hai” in China, is grown in forests and mountains by broadcasting the seeds of ginseng and is harvested at the cultivation age of 15–20 years. In this study, four new dammarane-type triterpenoids, ginsengenin-S1 (1), ginsengenin-S2 (2), ginsenoside-S3 (3), ginsenoside-S4 (4), along with one known compound were isolated from pearl knots of PGS. Ginsengenin-S2 significantly alleviated oxidative damage when A549 cells were exposed to cigarette smoke (CS) extract. In addition, ginsengenin-S2 could inhibit the CS-induced inflammatory reaction in A549 cells. Protective effects of ginsengenin-S2 against CS-mediated oxidative stress and the inflammatory response in A549 cells may involve the Nrf2 and HDAC2 pathways.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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Four Novel Dammarane-Type Triterpenoids from Pearl Knots of Panax ginseng Meyer cv. Silvatica

Guan

et al. 2019

Molecules

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“…Ginsenosides, the main active ingredient in Panax ginseng, Panax quinquefolium , and Panax notoginseng , are often classified into four groups: Protopanaxadiol type, protopanaxatriol type, oleanane-type, and ocotillol-type [3,4]. Numerous studies have demonstrated that ginsenosides are the major active compounds of antioxidant, anti-obesity, anti-inflammation, neuroprotective, anti-tumor, anti-coagulant, and immunoregulatory effects in P .…”

Section: Introductionmentioning

confidence: 99%

Immunomodulatory Effects of (24R)-Pseudo-Ginsenoside HQ and (24S)-Pseudo-Ginsenoside HQ on Cyclophosphamide-Induced Immunosuppression and Their Anti-Tumor Effects Study

Zeng

Chen

et al. 2019

IJMS

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(24R)-pseudo-ginsenoside HQ (R-PHQ) and (24S)-pseudo-ginsenoside HQ (S-PHQ) are the main metabolites of (20S)-ginsenoside Rh2 (Rh2) in vivo. In this study, we found that Rh2, R-PHQ, and S-PHQ upregulated the innate and adaptive immune response in cyclophosphamide (CTX) induced-immunocompromised mice as evidenced by the number of leukocytes, cellular immunity, and phagocytosis of macrophages. Spleen T-lymphocyte subpopulations and the serum cytokines level were also balanced in these immunosuppressed mice. Furthermore, co-administration with R-PHQ or S-PHQ did not compromise the antitumor activity of CTX in the hepatoma H22-bearing mice. Treatment with R-PHQ and S-PHQ clearly induced the apoptosis of tumor cells, significantly increased the expression of Bax, and remarkably inhibited the expression of Bcl-2 and vascular endothelial growth factor (VEGF) in H22 tumor tissues. The anti-tumor activity of R-PHQ and S-PHQ could be related to the promotion of tumor apoptosis and inhibition of angiogenesis and may involve the caspase and VEGF signaling pathways. This study provides a theoretical basis for further study on R-PHQ and S-PHQ.

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“…Ginseng, the root of Panax ginseng Meyer, was a widely used folk medicine in many Asian countries including China, Korea, and Japan for a thousand years [12,13]. It was reported that ginseng extract G115, the standardized extract of Panax ginseng , exhibits an antidepressant effect in ethanol-treated mice models via increasing brain-derived neurotrophic factor (BDNF) levels in the hippocampus and prefrontal cortex [14].…”

Section: Introductionmentioning

confidence: 99%

Study on Antidepressant Activity of Pseudo-Ginsenoside HQ on Depression-Like Behavior in Mice

et al. 2019

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Suppressive effects of ginsenoside Rh2 (Rh2), (24R)-pseudo-ginsenoside HQ (R-PHQ), and (24S)-pseudo-ginsenoside HQ (S-PHQ) against lipopolysaccharide (LPS)-induced depression-like behavior were evaluated using the forced swimming test (FST) and tail suspension test (TST) in mice. Pretreatment with Rh2, R-PHQ, and S-PHQ significantly decreased immobility time in FST and TST with clear dose-dependence, and significantly downregulated levels of serum tumor necrosis factor-α and interleukin-6, and upregulated superoxide dismutase activity in the hippocampus of LPS-challenged mice. Furthermore, R-PHQ and S-PHQ significantly increased the expression of the brain-derived neurotrophic factor (BDNF), tropomyosin-related kinase B (TrkB), sirtuin type 1 (Sirt1), and nuclear-related factor 2, and inhibited the phosphorylation of inhibitor of κB-α and nuclear factor-κB (NF-κB) in the hippocampus of LPS-challenged mice. Additionally, the antidepressant-like effect of R-PHQ was found related to the dopaminergic (DA), γ-aminobutyric acid (GABA)ergic, and noradrenaline systems, while the antidepressive effect of S-PHQ was involved in the DA and GABAergic systems. Taken together, these results suggested that Rh2, R-PHQ, and S-PHQ produced significant antidepressant-like effects, which may be related to the BDNF/TrkB and Sirt1/NF-κB signaling pathways.

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A new ocotillol-type ginsenoside from stems and leaves of Panax quinquefolium L. and its anti-oxidative effect on hydrogen peroxide exposed A549 cells

Cited by 14 publications

References 15 publications

Four Novel Dammarane-Type Triterpenoids from Pearl Knots of Panax ginseng Meyer cv. Silvatica

Four Novel Dammarane-Type Triterpenoids from Pearl Knots of Panax ginseng Meyer cv. Silvatica

Immunomodulatory Effects of (24R)-Pseudo-Ginsenoside HQ and (24S)-Pseudo-Ginsenoside HQ on Cyclophosphamide-Induced Immunosuppression and Their Anti-Tumor Effects Study

Study on Antidepressant Activity of Pseudo-Ginsenoside HQ on Depression-Like Behavior in Mice

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