A New O-Terpenoidal Coumarin from Clausena anisum-olens Merr.

Wang, Yunsong; Xu, Hong-Yi; Wang, Daxiang; Yang, Jing‐Hua

doi:10.3390/molecules14020771

Cited by 8 publications

(6 citation statements)

References 12 publications

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“…To date, coumarins and cyclopeptides were isolated from the leaves and twigs of this plant ( Wang et al. 2008a , b , 2009a , b ). The compositions of C. anisum-olens essential oil were also analyzed previously ( Molino 2000 , Su and Liang 2011 ).…”

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Contact Toxicity and Repellency of the Main Components From the Essential Oil ofClausena anisum-olensAgainst Two Stored Product Insects

et al. 2015

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The essential oil of Clausena anisum-olens (Blanco) Merr. showed strong contact toxicity and repellency against Lasioderma serricorne and Liposcelis bostrychophila adults. The components of the essential oil obtained by hydrodistillation were determined by gas chromatography-mass spectrometry. It was found that the main components were myristicin (36.87%), terpinolene (13.26%), p-cymene-8-ol (12.38%), and 3-carene (3.88%). Myristicin and p-cymene-8-ol were separated by silica gel column chromatography, and their molecular structures were confirmed by means of physicochemical and spectrometric analysis. Myristicin and p-cymene-8-ol showed strong contact toxicity against L. serricorne (LD50 = 18.96 and 39.68 μg per adult) and Li. bostrychophila (LD50 = 20.41 and 35.66 μg per adult). The essential oil acting against the two grain storage insects showed LD50 values of 12.44 and 74.46 μg per adult, respectively. Myristicin and p-cymene-8-ol have strong repellent toxicity to Li. bostrychophila.

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Contact Toxicity and Repellency of the Main Components From the Essential Oil ofClausena anisum-olensAgainst Two Stored Product Insects

et al. 2015

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“…The aerial parts of C. anisum-olens, which grows in Yunnan Province, China, are used in folk medicine to treat dysentery and arthritis [12]. Our previous phytochemical investigations of this species led to the discovery of new monoterpenoid coumarins [12,[24][25][26][27][28]. As part of our search for new natural products and bioactive compounds from medicinal plants of Clausena in Yunnan, a chemical reinvestigation of the ethanolic extract of the aerial parts of C. anisum-olens was then carried out.…”

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Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation

et al. 2019

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Two new carbazole alkaloids (1,2) and six known carbazole alkaloids (3–8) were isolated from Clausena anisum-olens. Their structures were elucidated based on extensive spectroscopic analysis. All isolated compounds (1–8) were evaluated for their anti-HIV effects on virus replication in MT-4 lymphocytes infected by HIV-1NL4-3 Nanoluc-sec virus, and new carbazole alkaloid 1 exhibited anti-HIV activity with an EC50 value of 2.4 μg/mL and SI of 7.1.

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“…Its aerial parts have been reported to be effective for dysentery and arthritis (Wang et al. 2009 ). Phytochemical studies on the genus Clausena revealed the presence of alkaloids, terpenes, amides, and coumarins (Khan & Naqvi 1988 ; Yang et al.…”

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Lipid-lowering property of Clausena anisum-olens in hypercholesterolemic rats

Bautista

Tan

Apostol

2017

Pharmaceutical Biology

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Context:Clausena anisum-olens (Blanco) Merr. (Rutaceae) is a medicinal shrub which has been reported to have various pharmacological uses. No study regarding the effects of C. anisum-olens on cholesterol-lowering has been reported.Objective: The effects of the ethanol extract of C. anisum-olens leaves on the cholesterol level of hypercholesterolemic rats were evaluated.Materials and methods: Acute oral toxicity of the extract (175, 550 and 2000 mg/kg) was determined using female Sprague-Dawley rats, as described in OECD 425 Main test guidelines. The lipid-lowering assay utilized 30 male Sprague-Dawley rats divided into five groups (A–E). Triton X-100 was administered to induce hypercholesterolemia. After hypercholesterolemia induction, oral treatment of Atorvastatin and crude ethanol extract was given daily to the treatment groups for 14 days. The total cholesterol, triglycerides, HDL and LDL were determined before induction, after induction, after first week of treatment and after second week of treatment.Results: Acute oral toxicity showed the crude extract is nontoxic up to 2000 mg/kg. The lipid-lowering assay indicated reduction of serum cholesterol (87.21 ± 5.10 mg/dL), triglycerides (58.09 ± 4.10 mg/dL) and LDL (27.82 ± 4.11 mg/dL) for 200 mg/kw extract. Reduction in serum cholesterol (74.72 ± 3.64 mg/dL), triglycerides (52.79 ± 2.98 mg/dL) and LDL (12.06 ± 5.51 mg/dL) were observed for 400 mg/kg group. The result is comparable to Atorvastatin, which showed serum cholesterol (80.90 ± 9.72 mg/dL), triglycerides (55.94 ± 7.19 mg/dL) and LDL (22.09 ± 7.60 mg/dL) reduction.Discussion and conclusion: The crude extract of C. anisum-olens proved to be useful in lowering of cholesterol.

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A New O-Terpenoidal Coumarin from Clausena anisum-olens Merr.

Cited by 8 publications

References 12 publications

Contact Toxicity and Repellency of the Main Components From the Essential Oil ofClausena anisum-olensAgainst Two Stored Product Insects

Contact Toxicity and Repellency of the Main Components From the Essential Oil ofClausena anisum-olensAgainst Two Stored Product Insects

Carbazole Alkaloids from Clausena anisum-olens: Isolation, Characterization, and Anti-HIV Evaluation

Lipid-lowering property of Clausena anisum-olens in hypercholesterolemic rats

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