A new non-destructive method for chemical analysis of particulate matter filters: The case of manganese air pollution in Vallecamonica (Italy)

Borgese, Laura; Zacco, Annalisa; Pal, Sudipto; Bontempi, Elza; Lucchini, Roberto; Zimmerman, Neil J.; Depero, Laura E.

doi:10.1016/j.talanta.2010.12.048

Cited by 43 publications

(54 citation statements)

References 31 publications

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“…Mn exposure of these children has been carefully monitored by measurements of Mn concentrations in samples from the their home environment and shown increased Mn concentrations in samples from the Valcamonica and Bagnolo Mella compared to Lake Garda (Borgese et al, 2011, 2013; Lucas et al, 2015). The children have also undergone comprehensive neurological and neuropsychological testing at adolescent age, including tests for IQ, motor function and behaviour; however, neurological outcomes were not in included in the present study.…”

Section: Methodsmentioning

confidence: 99%

Polymorphisms in manganese transporters show developmental stage and sex specific associations with manganese concentrations in primary teeth

et al. 2018

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Background: Manganese (Mn) is an essential metal that can become neurotoxic at elevated levels with negative consequences on neurodevelopment. We have evaluated the influence of single nucleotide polymorphisms (SNPs) in Mn transporter genes SLC30A10 and SLC39A8 on Mn concentrations in dentine, a validated biomarker that reflects Mn tissue concentrations early in life. Methods: The study included 195 children with variable environmental Mn exposure. Mn concentrations in dentine representing fetal, early postnatal and early childhood developmental periods were measured using laser ablation-inductively coupled plasma mass spectrometry. SLC30A10 rs12064812 (T/C) and SLC39A8 rs13107325 (C/T) were genotyped by TaqMan real time PCR and SLC30A10 rs1776029 (G/A) by pyrosequencing; and SNPs were analyzed in association with Mn in dentine. Results: SLC39A8 rs13107325 rare allele (T) carriers had significantly higher Mn concentrations in postnatal dentine (110%, p = 0.008). For all SNPs we also observed non-significant associations with Mn concentrations in dentine in opposite directions for fetal and early postnatal periods. Furthermore, there were significant differences in the influence of SLC30A10 rs1776929 genotypes on Mn concentrations in dentine between sexes. Discussion: The findings from this study indicate that common SNPs in Mn transporters influence Mn homeostasis in early development and may therefore be important to consider in future studies of early life Mn exposure and health effects. Our results also suggest that the influence of these transporters on Mn regulation may differ by developmental stage, as well as between girls and boys.

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Section: Methodsmentioning

confidence: 99%

Polymorphisms in manganese transporters show developmental stage and sex specific associations with manganese concentrations in primary teeth

et al. 2018

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“…Measurements were performed for 600 s with a Bruker S2 PICOFOX spectrometer equipped with molybdenum X-rays tube operating at 50 kV and 750 µA and Silicon-Drift Detector (SDD) (SDD) (Borgese et al 2011(Borgese et al , 2012. Detection limits were 1 mg for K, Ca, Cr, Mn, Fe, Co, Ni, Cu, Zn, Ga, As, Sr, Ba, Tl, Pb and Bi.…”

Section: Analytical Methodologymentioning

confidence: 99%

Aerosol Pollutants during Agricultural Biomass Burning: A Case Study in Ba Vi Region in Hanoi, Vietnam

Popovicheva

Shonija

Persiantseva

et al. 2017

Aerosol Air Qual. Res.

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Impact of traditional biomass burning activities on regional air quality is a major environmental concern. Measurement campaigns were performed during post-harvesting activities in the Ba Vi region in Hanoi in May-June of 2015 and 2016. To quantify the source for regional haze the sampling of rice straw burning emissions was performed on fields. Carbonaceous (OC, EC, BrC) fractions, heavy metals, organic and ionic composition, and microstructure were characterized. A set of functionalities (hydroxyl, aliphatic, carbonyl, carboxylate, and nitro groups) revealed a functional marker of pile combustion. Optical, microstructural, and chemical analyses of environmentally-dangerous pollutants from traffic and cooking sources provided characteristics and functional markers of different pollution sources. Chemical features of rice straw burning were identified on the Ba Vi site during the haze episode of 2015, when PM 10 mass approached the high smoke intensity, up to 167 µg m -3 . Small-scale meteorology affected PM 10 , OC and EC, and ion mass in days of highest relative humidity and fogs. In days of highest smoke OC dominated PM 10 mass by up to 42%, the OC/EC ratio approached 20, in line with observations of mainly smoldering emissions across the fields. Spectral features of regional haze smoke demonstrated the absorption of rice straw burning whereas the impact of biogenic, traffic, and cooking sources were significantly lower. Individual particle analyses showed carbonaceous particles internally/externally mixed with inorganic fly ash and dust. Smoke micromarkers revealed the microstructure of regional aerosols representative for Southeast Asia in BB periods. Significantly lower PM 10 mass concentrations and strong difference in aerosol composition before post-harvesting activities suggested that agricultural burning represents a large contribution to air quality degradation in the rural area of Vietnam.

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“…More detailed information on the study areas were published previously (Lucchini et al, 2007, 2012). Environmental levels of Mn and other metals have been thoroughly characterized in the study regions, showing that levels of Mn are significantly higher in Valcamonica compared to the Garda Lake reference area for airborne particles (Borgese et al 2011, 2012), deposited outdoor dust (Zacco et al 2009), indoor house and attic dust (Pavilonis, submitted), soil (Borgese et al, 2013), and locally cultivated leafy vegetables (Ferri et al 2012). …”

Section: Methodsmentioning

confidence: 99%

Neurofunctional dopaminergic impairment in elderly after lifetime exposure to manganese

et al. 2014

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Background Manganese (Mn) is an essential element that can become neurotoxic through various exposure windows over the lifespan. While there is clear evidence of Mn neurotoxicity in pediatric and adult occupational populations, little is known about effects in the elderly who may exhibit enhanced susceptibilities due to compromised physiology compared to younger adults. In the province of Brescia, Italy, the Valcamonica area has been the site of three ferroalloy plants operating from 1902 to 2001. Metal emissions of Mn and to a lesser extent lead (Pb) have impacted the surrounding environment, where a high prevalence of Parkinsonism was previously observed. This study aimed to assess neurocognitive and motor functions in healthy elderly subjects residing for most of their lifetime in Valcamonica or in a reference area unimpacted by ferroalloy plant activity. Methods Subjects were enrolled for extensive neurobehavioral assessment of motor, cognitive and sensory functions. Exposure was assessed with 24hour personal air sampling for PM10 airborne particles, surface soil and tap water measurement at individual households, Mn levels in blood and urine and Pb in blood. Dose-response relationships between exposure indicators and biomarkers and health outcomes were analyzed with Generalized (linear and logistic) Additive Models (GAM). Results A total of 255 subjects (55% women) were examined; most (52.9%) were within the 65–70 years age class. Average airborne Mn was 26.41 ng/m3 (median 18.42) in Valcamonica and 20.96 ng/m3 (median 17.62) in the reference area. Average Mn in surface soil was 1026 ppm (median 923) in Valcamonica and 421 ppm (median 410) in the reference area. Manganese in drinking water was below the LDL of 1 µg/L. The GAM analysis showed significant association between airborne Mn (p=0.0237) and the motor coordination tests of the Luria Nebraska Neuropsychological Battery. The calculation of the Benchmark Dose using this dose response relationship yielded a lower level confidence interval of 22.7 ng/m3 (median 26.4). For the odor identification score of the Sniffin Stick test, an association was observed with soil Mn (p=0.0006) and with a significant interaction with blood Pb (p=0.0856). Significant dose-responses resulted also for the Raven’s Colored Progressive Matrices with the distance from exposure point source (p=0.0025) and Mn in soil (p=0.09), and for the Trail Making test, with urinary Mn (p=0.0074). Serum prolactin (PRL) levels were associated with air (p=0.061) and urinary (p=0.003) Mn, and with blood Pb (p=0.0303). In most of these associations age played a significant role as an effect modifier. Conclusion Lifelong exposure to Mn was significantly associated with changes in odor discrimination, motor coordination, cognitive abilities and serum PRL levels. These effects are consistent with the hypothesis of a specific mechanism of toxicity of Mn on the dopaminergic system. Lead co-exposure, even at very low levels, can further enhance Mn toxicity.

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A new non-destructive method for chemical analysis of particulate matter filters: The case of manganese air pollution in Vallecamonica (Italy)

Cited by 43 publications

References 31 publications

Polymorphisms in manganese transporters show developmental stage and sex specific associations with manganese concentrations in primary teeth

Polymorphisms in manganese transporters show developmental stage and sex specific associations with manganese concentrations in primary teeth

Aerosol Pollutants during Agricultural Biomass Burning: A Case Study in Ba Vi Region in Hanoi, Vietnam

Neurofunctional dopaminergic impairment in elderly after lifetime exposure to manganese

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