A new naturally acetylated triterpene saponin from Nigella sativa

Mehta, B. K.; Mehta, Prabha; Gupta, Monika

doi:10.1016/j.carres.2008.10.004

Cited by 23 publications

(13 citation statements)

References 30 publications

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“…These observations are consistent with the fact that the triterpenoid saponins and flavonoid glycoside are more soluble in aqueous methanol. The assignment of compounds were supported by comparison with the literature data [thymol and thymol-b-glucopyranoside (Ahmed and Jakupovic, 1990), thymoquinone (de Sousa et al, 2011), fatty acids (Knothe and Kenar, 2004), p-cymene (Schwarz and Ernst, 1996), cycloartenol (Mehta et al, 2009), sucrose, quercetin, and kaempferol (Maulidiani et al, 2012)]. Identification of thymol, thymoquinone, fatty acids, pcymene, thymol-b-glucopyranoside, and sucrose was also confirmed by 2D NMR data (HMBC and J resolved).…”

Section: Assignment Of Compounds From the 1 H Nmr Spectramentioning

confidence: 65%

“…It has been shown that the biological properties of the essential oils are directly associated with the chemical composition, which varies depending on the origin (Bourgou et al, 2010). Several of the pharmacologically interesting substances have also been isolated from Nigella seeds including isoquinoline and indazole alkaloids (Atta, 2003;Atta-ur-Rahman et al, 1995), saponins (Mehta et al, 2009), cycloartenols (Mehta et al, 2008), and flavonoid glycosides (Merfort et al, 1997).…”

Section: Introductionmentioning

confidence: 98%

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Differentiation of Nigella sativa seeds from four different origins and their bioactivity correlations based on NMR-metabolomics approach

Maulidiani

Sheikh

Mediani

et al. 2015

Phytochemistry Letters

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Section: Assignment Of Compounds From the 1 H Nmr Spectramentioning

confidence: 65%

Section: Introductionmentioning

confidence: 98%

Differentiation of Nigella sativa seeds from four different origins and their bioactivity correlations based on NMR-metabolomics approach

Maulidiani

Sheikh

Mediani

et al. 2015

Phytochemistry Letters

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“…Steroidal glycosides of new and known structures have been isolated from N. sativa seeds which include 3- O -[ β -D-xylopyranosyl-(1→2)- α -L-rhamnopyranosyl-(1→2)- β -D-glucopyranosyl]-11-methoxy-16, 23-dihydroxy-28-methylolean-12-enoate, stigma-5,22-dien-3- β -D-glucopyranoside [24], and 3- O -[ β -D-xylopyranosyl-(1→3)- α -L-rhamnopyranosyl-(1→4)- β -D-glucopy-ranosyl]-11-methoxy-16-hydroxy-17-acetoxy hederagenin [25]. Moreover, alkaloids of diverse types have been isolated from the seeds of black cumin, which include novel Dolabellane-type diterpene alkaloids: nigellamines A 1 , A 2 , B 1 , and B 2 and nigellamines A3, A4, A5, and C [26, 27] possessing lipid metabolizing property, and indazole class of alkaloids: nigellidine, nigellicine [28, 29], and nigellidine-4-O-sulfite [30].…”

Section: High-value Bioactive Compounds (Phytochemicals) In the Sementioning

confidence: 99%

Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses

Yimer

Tuem

Karim

et al. 2019

Evidence-Based Complementary and Alternative Medicine

313

228

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The seed of Nigella sativa (N. sativa) has been used in different civilization around the world for centuries to treat various animal and human ailments. So far, numerous studies demonstrated the seed of Nigella sativa and its main active constituent, thymoquinone, to be medicinally very effective against various illnesses including different chronic illness: neurological and mental illness, cardiovascular disorders, cancer, diabetes, inflammatory conditions, and infertility as well as various infectious diseases due to bacterial, fungal, parasitic, and viral infections. In spite of limited studies conducted so far, the promising efficacy of N. sativa against HIV/AIDS can be explored as an alternative option for the treatment of this pandemic disease after substantiating its full therapeutic efficacy. Moreover, the strong antioxidant property of this valued seed has recently gained increasing attention with regard to its potential role as dietary supplement with minimal side effects. Besides, when combined with different conventional chemotherapeutic agents, it synergizes their effects resulting in reducing the dosage of concomitantly used drugs with optimized efficacy and least and/or no toxicity. A number of pharmaceutical and biological properties have been ascribed to seeds of N. sativa. The present review focuses on the profile of high-value components along with traditional medicinal and biological principles of N. sativa seed and its oil so as to explore functional food and nutraceutical potential of this valued herb.

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“…While N. sativa and R. rosea extracts did not inhibit IBV, many of their phytochemicals are thought to be antiviral. For example, N. sativa seed extracts predominantly contain saponins, glycosides, terpenoids and alkaloids [38,[63][64][65][66][67], many of which are similar to known antiviral chemicals [38][39][40]68]. On the other hand, R. rosea root extracts consist of many kaempferol, herbacetin, dihydromyricetin, and myricetin derivatives [32].…”

Section: Discussionmentioning

confidence: 99%

Sambucus nigra extracts inhibit infectious bronchitis virus at an early point during replication

et al. 2014

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BackgroundInfectious bronchitis virus (IBV) is a pathogenic chicken coronavirus. Currently, vaccination against IBV is only partially protective; therefore, better preventions and treatments are needed. Plants produce antimicrobial secondary compounds, which may be a source for novel anti-viral drugs. Non-cytotoxic, crude ethanol extracts of Rhodiola rosea roots, Nigella sativa seeds, and Sambucus nigra fruit were tested for anti-IBV activity, since these safe, widely used plant tissues contain polyphenol derivatives that inhibit other viruses.ResultsDose–response cytotoxicity curves on Vero cells using trypan blue staining determined the highest non-cytotoxic concentrations of each plant extract. To screen for IBV inhibition, cells and virus were pretreated with extracts, followed by infection in the presence of extract. Viral cytopathic effect was assessed visually following an additional 24 h incubation with extract. Cells and supernatants were harvested separately and virus titers were quantified by plaque assay. Variations of this screening protocol determined the effects of a number of shortened S. nigra extract treatments. Finally, S. nigra extract-treated virions were visualized by transmission electron microscopy with negative staining.Virus titers from infected cells treated with R. rosea and N. sativa extracts were not substantially different from infected cells treated with solvent alone. However, treatment with S. nigra extracts reduced virus titers by four orders of magnitude at a multiplicity of infection (MOI) of 1 in a dose-responsive manner. Infection at a low MOI reduced viral titers by six orders of magnitude and pretreatment of virus was necessary, but not sufficient, for full virus inhibition. Electron microscopy of virions treated with S. nigra extract showed compromised envelopes and the presence of membrane vesicles, which suggested a mechanism of action.ConclusionsThese results demonstrate that S. nigra extract can inhibit IBV at an early point in infection, probably by rendering the virus non-infectious. They also suggest that future studies using S. nigra extract to treat or prevent IBV or other coronaviruses are warranted.

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A new naturally acetylated triterpene saponin from Nigella sativa

Cited by 23 publications

References 30 publications

Differentiation of Nigella sativa seeds from four different origins and their bioactivity correlations based on NMR-metabolomics approach

Differentiation of Nigella sativa seeds from four different origins and their bioactivity correlations based on NMR-metabolomics approach

Nigella sativa L. (Black Cumin): A Promising Natural Remedy for Wide Range of Illnesses

Sambucus nigra extracts inhibit infectious bronchitis virus at an early point during replication

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