A new murine model of accelerated senescence

Takeda, Takeshi; Hosokawa, Masanori; Takeshita, S; Irino, Mika; Higuchi, Kenichi; Matsushita, Takatoshi; Tomita, Yumiko; Yasuhira, Kimio; Hamamoto, Hiromi; Shimizu, Katsuji; Ishii, Masaharu; Yamamuro, Takao

doi:10.1016/0047-6374(81)90084-1

Cited by 806 publications

(420 citation statements)

References 10 publications

Supporting

Mentioning

410

Contrasting

Unclassified

Order By: Relevance

“…Recently, transgenic mice have been produced by microinjecting the cloned human mutant gene. It is well documented that apolipoproteins are an important constituent of amyloid fibrils in human and mice amyloidosis (14,15). Moreover, Apo B and E were stained in the amyloid fibrils in the brain of patients with Alzheimer's disease.…”

Section: Resultsmentioning

confidence: 96%

Transthyretin and Familial Amyloidotic Polyneuropathy.

1993

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 96%

Transthyretin and Familial Amyloidotic Polyneuropathy.

1993

View full text Add to dashboard Cite

“…However, despite these differences, the longevity between the two groups was the same. Surprisingly, the Dnmt1 deficient mice also developed jejunal apolipoprotein AII amyloidosis in aging, reminiscent of the spontaneous development of age-associated amyloidosis that has been described in a mouse model of accelerated senescence (74). While both the Dnmt1 heterozygous knockout and the control mice have decreased Dnmt1 expression with aging, the expression of the de novo methyltransferases Dnmt3a and 3b increased with aging in T cells from control animals.…”

Section: Cross-talk Between Epigenetics Aging and Late-life Diseasesmentioning

confidence: 94%

Epigenetics, aging, and autoimmunity

Yung

Julius

2008

Autoimmunity

View full text Add to dashboard Cite

The decline in immunocompetence with age is accompanied by the increase in the incidence of autoimmune diseases. Aging of the immune system, or immunosenescence, is characterized by a decline of both T and B cell function, and paradoxically the presence of low grade chronic inflammation. There is growing evidence that epigenetics, the study of inherited changes in gene expression that are not encoded by the DNA sequence itself, changes with aging. Interestingly, emerging evidence suggests a key role for epigenetics in human pathologies, including inflammatory and neoplastic disorders. Here we will review the potential mechanisms that contribute to the increase in autoimmune responses in aging. In particular, we will discuss how epigenetic alterations, especially DNA methylation and histone acetylation, are accumulated during aging and how these events contribute to autoimmunity risk.

show abstract

“…The SAMP8 mouse strain was developed spontaneously from selective breeding of AKR/J mice (Takeda et al 1981). These animals exhibit early onset and irreversible advance of senescence, as demonstrated by the loss of normal behaviour, the appearance of skin lesions, increased lordokyphosis and a shortened lifespan (Takeda, 2009).…”

Section: Introductionmentioning

confidence: 99%

Presence of a neo-epitope and absence of amyloid beta and tau protein in degenerative hippocampal granules of aged mice

Manich

Valle

Cabezón

et al. 2013

AGE

View full text Add to dashboard Cite

Clustered pathological granules related to a degenerative process appear and increase progressively with age in the hippocampus of numerous mouse strains. We describe herein the presence of a neoepitope of carbohydrate nature in these granules, which is not present in other brain areas and thus constitutes a new marker of these degenerative structures. We also found that this epitope is recognised by a contaminant IgM present in several antibodies obtained from mouse ascites and from both mouse and rabbit sera. These findings entail the need to revise the high number of components that are thought to be present in the granules, such as the controversial β-amyloid peptides described in the granules of senescence-accelerated mouse prone-8 (SAMP8) mice. Characterisation of the composition of SAMP8 granules, taking into account the presence of the neo-epitope and the contaminant IgM, showed that granules do not contain either β-amyloid peptides or tau protein. The presence of the neo-epitope in the granules but not in other brain areas opens up a new direction in the study of the neurodegenerative processes associated with age. The SAMP8 strain, in which the progression of the granules is enhanced, may be a useful model for this purpose.

show abstract

A new murine model of accelerated senescence

Cited by 806 publications

References 10 publications

Transthyretin and Familial Amyloidotic Polyneuropathy.

Transthyretin and Familial Amyloidotic Polyneuropathy.

Epigenetics, aging, and autoimmunity

Presence of a neo-epitope and absence of amyloid beta and tau protein in degenerative hippocampal granules of aged mice

Contact Info

Product

Resources

About